Detection rate for sexually transmitted infections by screening for three anatomic loci in at-risk patients


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Abstract

Objective. To study the prevalence of N. gonorrhoeae, C. trachomatis, M. genitalium, T. vaginalis, and T. pallidum in three anatomical loci during out-of-hospital examination of at-risk men and women [males who have sex with males (MSM); commercial sex workers (sex workers (SW)]. Subjects and methods. The investigation enrolled 202 at-risk representatives who lived in Moscow and the Moscow Region. Real-time PCR was used to determine the causative agents of sexually transmitted infections (STIs) in the biomaterial of females (scrape/swab from the cervical canal, oropharynx, and anus) and males (primary urine sample, scrape/swab from the oropharynx and anus). Results. The out-of-hospital examination showed that the incidence of STIs in at-risk patients was 43.6%. The highest prevalence of STIs was observed in the HIV-infected and non-HIV infected MSM (HIV/MSM and non- HIV/MSM) (54 and 44%, respectively) and the less frequent prevalence was seen in female SWs (29.2%). Regardless of the anatomical locus, the detected STI pathogens included C. trachomatis (19.3%), N. gonorrhoeae (14.9%), M. genitalium (13.9%), T. pallidum (4%), and T. vaginalis (1%). Extragenital (rectal and/or oropharyngeal) STIs were more common (70%); genital STIs were noted in 7.1%; genital concurrent with extragenital STIs were recorded in 22.9%. Extragenital STIs were more often detected among HIV/MSM(79.4%) and non-HIV/MSM (75.0%). The SW group exhibited a concurrence of genital and extragenital STIs more frequently (50%). Conclusion. The high prevalence of STIs in at-risk patients necessitates the introduction of new algorithms for their examination, in particular, biomaterial collection from three anatomical loci for PCR.

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About the authors

Anna A. Popova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: asya-med@mail.ru
Cand. Med. Sci., Senior Researcher, Department of Specialized Research Laboratory for AIDS Epidemiology and Prevention

Anastasia V. Pokrovskaya

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Peoples' Friendship University of Russia

Email: pokrovskaya_av@mail.ru
Cand. Med. Sci., Senior Researcher

Elizaveta D. Shedko

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: shedko@cmd.su
Junior Researcher, Laboratory for Molecular Diagnosis and Epidemiology of Reproductive Tract Infections

Anastasia V. Gromova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: gromova@cmd.su
Cand. Biol. Sci., Researcher, Laboratory for Molecular Diagnosis and Epidemiology of Reproductive Tract Infections

Tatyana S. Skachkova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: skachkova@inbox.ru
Researcher, Laboratory for Molecular Diagnosis and Epidemiology of Reproductive Tract Infections

Elena N. Goloveshkina

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: goloveshkina@cmd.su
Cand. Biol. Sci., Head, Laboratory for Molecular Diagnosis and Epidemiology of Reproductive Tract Infections

Kirill A. Barsky

«Shagi» (Steps) Regional Charitable Public AIDS Control Foundation

Email: hivpress@gmail.com
Master of Public Health, Program Manager «Shagi»

Alexander A. Kalinin

«Shagi» (Steps) Regional Charitable Public AIDS Control Foundation

Email: aleksandr.an@gmail.com
Social Worker

Igor V. Pchelin

«Shagi» (Steps) Regional Charitable Public AIDS Control Foundation

Email: shagi@hiv-aids.ru
Chairman of the Board «Shagi»

References

  1. Unemo M., Bradshaw C.S., Hocking J.S., de Vries H.J.C., Francis S.C., Mabey D. et al. Sexually transmitted infections: challenges ahead. Lancet Infect. Dis. 2017; 17(8): e235-e279. doi: 10.1016/S1473-3099(17)30310-9
  2. Chesson H.W., Mayaud P., Aral S.O. Sexually Transmitted Infections: Impact and Cost-Effectiveness of Prevention. In: Holmes K.K., Bertozzi S., Bloom B.R., Jha P. (eds.). Major Infectious Diseases. 3rd ed. Washington (DC): The International Bank for Reconstruction and Development/ The World Bank; 2017. Chapter 10.
  3. Кубанов А.А., Богданова Е.В. Динамика заболеваемости инфекциями, передаваемыми половым путем, в различных группах взрослого населения Российской Федерации в 2011-2019 годах. Инфекционные болезни 2020; 18(4): 58-73. doi: 10.20953/1729-9225-2020-4-58-73
  4. European Centre for Disease Prevention and Control. Gonorrhoea. In: ECDC. Annual epidemiological report for 2017. Stockholm: ECDC, 2019. https://www.ecdc.europa.eu/en/publications-data/gonorrhoea-annualepidemiological-report-2017#no -link
  5. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2018. Atlanta: U.S. Department of Health and Human Services, 2019. doi: 10.15620/cdc.79370. https://www.cdc.gov/std/stats
  6. ESTICOM. D1: Review of HIV and sexually transmitted infections among men who have sex with men (MSM) in Europe. 2017. https://www.esticom.eu/Webs/ESTICOM/EN/emis-2017/msm-review/D1_Review_HIV_ STI_MSM. pdf?_blob=publicationFile&v=3
  7. Stenger M.R., Pathela P., Anschuetz G. Bauer H., Simon J., Kohn R. et al. Increases in the rate of neisseria gonorrhoeae among gay, bisexual and other men who have sex with men-findings from the sexually transmitted disease surveillance network 2010-2015. Sex. Transm. Dis. 2017; 44: 393-7. https://doi.org/10.1097/OLQ.0000000000000623
  8. Тюленев Ю.А., Гущин А.Е., Кисина В.И. Особенности локализации инфекций, передаваемых половым путем, у субъективно асимптомных мужчин, практикующих секс с мужчинами. Клиническая дерматология и венерология 2021; 20(1): 55-61. https://doi.org/10.17116/klinderma20212001155
  9. Тюленев Ю.А., Гущин А.Е. Инфекции, передаваемые половым путем, среди мужчин, практикующих секс с мужчинами, с бессимптомным течением заболевания. Клиническая дерматология и венерология 2020; 19(6): 802-8. https://doi.org/10.17116/klinderma202019061802
  10. Плавинский С.Л., Ладная Н.Н., Баринова А.Н., Зайцева Е.Е. Распространенность ВИЧ-инфекции и рискованного поведения среди уязвимых групп населения в 7 регионах Российской Федерации: результаты био-поведенческого исследования 2017 г. М.: ОИЗ, 2018. 136 с
  11. ECDC Technical Report. EMIS-2017 - The European Men-Who-Have-Sex-With-Men Internet Survey. https://www.ecdc.europa.eu/en/publications-data/emis-2017-european-men-who-have-sex-men-internet-survey

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