Clinical and epidemiological features of staphylococcal enterocolitis in infants: a retrospective study

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. Identification of clinical and epidemiological features of staphylococcal enterocolitis (SE) in infants.

Materials and methods. Based on a study of 198 case histories of patients under the age of 1 year treated at the Regional Infectious Diseases Clinical Hospital named after A.M. Nichoga (Astrakhan) from January 2017 to December 2021, the duration of the main symptoms of SE (fever, diarrhea, toxicosis with dehydration, the frequency of intestinal dysbiosis and secondary lactase deficiency) was analyzed.

Results. The age structure of patients with SE was dominated by children under 6 months of age (68%). 57% of children had a history of prematurity, omphalitis, purulent conjunctivitis, etc., and 86% of children were on formula and mixed feeding. The food route of infection was identified in 78% of children. In 62% of patients, the disease was moderate. Among the lesions of the gastrointestinal tract, enterocolitis and gastroenterocolitis accounted for 79%, colitis and hemocolitis – 14%, enteritis – 7%, dehydration – 16%, intestinal dysbiosis - 44%, secondary lactase deficiency – 48%. A direct correlation between late hospitalization of patients (3 days after the onset of the disease) and the presence of dehydration was established (r = 0.72; p < 0.001).

Conclusion. Intestinal staphylococcal infection in infants most often occurred in the form of primary SE (70%) with a predominance of moderate forms (62%) and the development of secondary lactase deficiency (48%). The duration of the disease, fever, diarrhea syndrome, and repeated isolation of staphylococcus in patients with secondary SE is higher than in primary ones.

Full Text

Restricted Access

About the authors

Olga G. Kimirilova

Astrakhan State Medical University of the Ministry of Health of Russia

Author for correspondence.
Email: 0lgakim@mail.ru
ORCID iD: 0000-0003-4066-2431

д.м.н., профессор, заведующий кафедрой детских инфекций

Russian Federation, Astrakhan

Gennady A. Kharchenko

Astrakhan State Medical University of the Ministry of Health of Russia

Email: Xarchenkoga@mail.ru
ORCID iD: 0000-0001-7764-0995

MD, Professor, Head, Department of Childhood Infections

Russian Federation, Astrakhan

References

  1. Никольская М.В. Клинико-этиологическая характеристика острых кишечных инфекций у госпитализированных детей. Известия высших учебных заведений. Поволжский регион. Медицинские науки 2018; 46(2): 97–106. https://doi.org/10.21685/2072-3032-2018-2-11 Nikolskaya M.V. [Clinical and etiological characteristics of acute intestinal infections in hospitalized children. News of higher educational institutions. Volga Region]. Medical sciences 2018; 46(2): 97–106. (In Russ.). https://doi.org/10.21685/2072-3032-2018-2-11
  2. Mokomane M., Kasvosve I., de Melo E., Pernica J., GoldfarbD.The global problem of childhood diarrhoeal diseases: emerging strategies in prevention and management. Therapeutic Advances in Infectious Disease 2018; 5(1): 29–43. https://doi.org/10.1177/2049936117744429
  3. Романов А.В., Чернов Е.А., Эйдельштейн М.В. Молекулярная эпидемиология внутрибольничных золотистых стафилококков в стационарах различных регионов России. Молекулярная медицина 2013; (4): 55–64. Romanov A.V., Chernov E.A., Eidelshtein M.V. [Molecular epidemiology of nosocomial Staphylococcus aureus in hospitals of various regions of Russia]. Molecular Medicine 2013; (4): 55–64. (In Russ.).
  4. Лагустов М.В. Грамположительные аэробные кокки: Иллюстрированное учебное пособие. Екатеринбург: УГМУ, 2016. 89 с. Lagustov M.V. [Gram-positive aerobic cocci. Illustrated tutorial]. Ekaterinburg, 2016. 89 p. (In Russ.).
  5. Тимофеева Г.А., Антипова Л.А. Инфекционные заболевания детей первого года жизни. М.: Медицина, 1985. 248 с. Timofeeva G.A., Antipova L.A. [Infectious diseases of children in the first year of life]. Moscow: Medicina, 1985. 248 р. (In Russ.).
  6. Манкевич Р.Н., Матуш Л.И., Лагир Г.М. Кампилобактериоз Стафилококковый энтероколит. Дисбактериоз кишечника у детей: учебно-методическое пособие. Минск: БГМУ, 2020. 40 с. Mankevich R.N., Matush L.I., Lagir G.M. [Campylobacteriosis Staphylococcal enterocolitis. Intestinal dysbiosis in children: educational and methodical manual]. Minsk, 2020. 40 р. (In Russ.).
  7. Николаева И.В., Анохин В.А. Стафилококковые инфекции в педиатрии. Практическая медицина 2010; 40(1): 24–7. Nikolaeva I.V., Anohin V.A. [Staphylococcal infections in pediatrics]. Practical medicine 2010; 40(1): 24–7. (In Russ.).
  8. Nikolaeva I.V., Pavlova T.Y., Fialkina S.V., Anokhin V.A., Fluer F.S., Rizvanov A.A. Expression of staphylokinasegene s. aureus strains isolated from breast milk and clinical outcomes in breastfed infants. BioNanoScience 2017; 7(2): 368–72. https://doi.org/ 10.1007/s12668-016-0364-0
  9. Харченко Г.А., Кимирилова О.Г. Клинико-эпидемиологические особенности острых кишечных инфекций, вызванных условно патогенными энтеробактериями у детей раннего возраста. Лечащий врач 2021; 24(4): 37–41. https://doi.org/10.51793/OS.2021.62.72.007 Harchenko G.A., Kimirilova O.G. [Clinical and epidemiological features of acute intestinal infections caused by conditionally pathogenic enterobacteria in young children]. Attending physician 2021; 24(4): 37–41. (In Russ.) https://doi.org/10.51793/OS.2021.62.72.007
  10. Скворцова В.А., Яцык Г.В., Звонкова Н.Г., Грибакин С.Г., Боровик Т.Э. Функциональные нарушения желудочно-кишечного тракта у детей грудного возраста: роль диетотерапии. Лечащий Врач 2011; (6): 65–6. Skvorcova V.A., Yаcyk G.V., Zvonkova N.G., Gribakin S.G., Borovik T.E. [Functional disorders of the gastrointestinal tract in infants: the role of diet therapy]. Attending physician 2011; (6): 65–6. (In Russ.).
  11. Старостина Л.С., Яблокова Е.А. Особенности функционирования пищеварительной системы у детей раннего возраста: коррекция наиболее частых расстройств. РМЖ 2017; 19: 1335–40. Starostina L.S., Yаblokova E.A. [Features of the functioning of the digestive system in young children: correction of the most frequent disorders]. Russian Medical Journal 2017; 19: 1335–40. (In Russ.).
  12. Колачевская К.А., Заварцева Л.И., Молочный В.П. Клинико-эпидемиологическая характеристика острых кишечных инфекций у детей раннего возраста г. Хабаровска. Дальневосточный медицинский журнал 2016; (3): 41–4. Kolachevskaya K.A., Zavarceva L.I., Molochnyj V.P. [Clinical and epidemiological characteristics of acute intestinal infections in children of early age of Khabarovsk]. Far Eastern Medical Journal 2016; (3): 41–4. (In Russ.).
  13. Николаева И.В., Анохин В.А., Айнутдинова И.А. Характеристика кишечной микрофлоры у здоровых детей раннего возраста г. Казани. Российский вестник перинатологии и педиатрии 2009; (2): 30–4. Nikolaeva I.V., Anokhin V.A., Ainutdinova I.A. [Characteristics of intestinal microflora in healthy young children of Kazan]. Russian Bulletin of Perinatology and Pediatrics 2009; (2): 30–4. (In Russ.).
  14. Ericson J.E., Popoola V.O., Smith P.B., Benjamin D.K., Fowler V.G., Benjamin D.K.et al. Burden of invasive Staphylococcus aureus infections in hospitalized infants. JAMA Pediatr. 2015; 169(12): 1105–11. https://doi.org/10.1001/jamapediatrics.2015.2380
  15. Claassen-Weitz S., Shittu A.O., Ngwarai M.R., Thabane L., Nicol M.P., Kaba M. Fecal carriage of Staphylococcus aureus in the hospital and community setting: A systematic review. Front. Microbiol. 2016; (7): 420–49. https://doi.org/10.3389/fmicb.2016.00449
  16. Shurland S., Zhan M., Bradham D.D., Roghmann M.-C. Comparison of mortality risk associated with bacteremia due to methicillinresistant and methicillin-susceptible Staphylococcus aureus. Infection Control and Hospital Epidemiology 2007; 28(3): 273–9. https://doi.org/10.1086/512627
  17. Brooks H.J.L., McСonnell M.A., Broadbent R.S. Microbes and the Inflammatory Response in Necrotizing Enterocolitis. Preterm Birth ed. O. Erez. New Zealand: University of Otago, 2013. 200 р. https://doi.org/10.5772/55039

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies