The role of possibly high carcinogenic risk human papilloma virus the development of cervical malignant pathology: systematic review and metaanalysis

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Abstract

Objective. Evaluation of the prevalence of possibly high carcinogenic risk (possibly HCR) human papillomavirus (HPV) and its contribution to the development of malignant cervical neoplasms with an assessment of the reliability of the data obtained depending on the diagnostic approaches used.

Materials and methods. The search in the MEDLINE (PubMed), CyberLeninka, and eLibrary databases (search depth – 21 years) was performed. In total, more than 400 articles in Russian, English, and German were analyzed. Statistical analyses of results and data visualization were performed in the R environment.

Results. It was found that the proportion of possibly HCR HPV from all HPV-positive results among conditionally healthy women (n = 20,989) was 14% (95% CI 9–20), in the group with a cytological conclusion LSIL and ASCUS (n = 2785) – 20% (95% CI 13–29). Among patients with a cytological conclusion HSIL and «cervical cancer» (n = 6316), the frequency of detection of possibly HCR HPV 26, 53, 66, 67 68, 70, 73, 82 types was a total of 6% (95% CI 3–16). When different diagnostic approaches are used simultaneously to exclude false-negative results, the number of HPV-negative cases of cervical cancer was 1% (95% CI 0–2). The comparable level of type-specific transforming activity of HCR and possibly HCR HPV indicates that possibly HCR HPV may be the only prognostic factor for the development of cervical cancer.

Conclusion. The data obtained indicate the need to recommend the inclusion of HPV of possibly HCR in epidemiological monitoring and screening programs for malignant cervical pathology.

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About the authors

Nadezhda А. Vinogradova

Central Research Institute of Epidemiology of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Author for correspondence.
Email: klimova@cmd.su
ORCID iD: 0000-0003-3288-0244

Junior Researcher

Russian Federation, Moscow

Elvira A. Domonova

Central Research Institute of Epidemiology of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: vinogradova.n@cmd.su
ORCID iD: 0000-0001-8262-3938

Cand. Boil. Sci., Head, Scientific Group for the Development of New Methods for Diagnosis of Opportunistic and Human Papillomavirus Infections

Russian Federation, Moscow

Michail A. Vinokurov

Central Research Institute of Epidemiology of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: vinokurov@cmd.su
ORCID iD: 0000-0002-4101-0702

Junior Researcher

Russian Federation, Moscow

Anna A. Popova

Central Research Institute of Epidemiology of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: asya-med@mail.ru
ORCID iD: 0000-0001-9484-5917

Cand. Med. Sci., Senior Researcher

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Frequency of detection of various CR HPV among women with cytological conclusions NILM (1st group, n = 20 989), LSIL and ASCUS (2nd group, n = 2785)

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3. Table 1. Frequency of detection of various CR HPV among women with a cytological conclusion of NILM (1st group, n = 20 989)

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4. Table 2. Frequency of detection of various CR HPV among women with cytological conclusions of LSIL and ASCUS (2nd group, n = 2785)

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5. Table 3. Frequency of detection of various CR HPV among women with cytological conclusions of HSIL and cervical cancer, depending on the use of various diagnostic approaches

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6. Fig. 2. Frequency of detection of HPV-negative samples among histologically confirmed cases of cervical cancer depending on the use of various diagnostic approaches

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