Assessment of cardiovascular risk in HIV-positive individuals with latent tuberculosis infection

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Аннотация

Objective. Assessment of cardiovascular risk in HIV-positive individuals with latent tuberculosis infection (LTBI).

Materials and methods. Screening for tuberculosis infection was performed in 395 patients with HIV infection followed-up in the AIDS Consultation and Diagnostic Department of the Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being. A positive result was obtained in 75 (19%) people. From these patients, the study group of 39 people with HIV and LTBI was formed. Control group included HIV-infected patients without LTBI, matching in gender, age, smoking status and antiretroviral therapy regimen with study group. Lipid profile parameters, ten-year risk of fatal and non-fatal cardiovascular events according to the SCORE2 scale, comorbidities, relative number of classical (CD14++CD16-), inflammatory (CD14++CD16+) and non-classical (CD14+CD16++) monocytes were analyzed in the groups.

Results. High risk according to the SCORE2 scale was found in 68% of the study group and 57% of the control group, very high risk – 28 and 32%, respectively. Arterial hypertension was found in 31% of the study group and 24% of the control group, metabolic syndrome – 17 and 5%. The CD14++CD16- monocytes level was higher than normal in 67% of patients in the sudy group and in 82% in the control group, and CD14+CD16++ were lower than normal in 97 and 100% of patients, respectively.

Conclusion. No statistically significant differences were found between the groups, however, it cannot be ruled out that LTBI is an additional factor contributing to atherogenesis in patients with HIV infection.

Толық мәтін

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Авторлар туралы

Ekaterina Kulabukhova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Peoples’ Friendship University of Russia named after Patrice Lumumba

Хат алмасуға жауапты Автор.
Email: ekulabukhova@mail.ru
ORCID iD: 0000-0003-3645-7275

Cand. Med. Sci., Assistant, Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, Infectiologist

Ресей, Moscow; Moscow

Olga Khokhlova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: xoxlova@cmd.su
ORCID iD: 0000-0001-9736-4043

Cand. Med. Sci., Head, Clinical and Laboratory Group, Doctor of Clinical Laboratory Diagnostics

Ресей, Moscow

Anastasia Pokrovskaya

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Peoples’ Friendship University of Russia named after Patrice Lumumba

Email: pokrovskaya@cmd.su
ORCID iD: 0000-0002-2677-0404

MD, Senior Researcher, Associate Professor, Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute

Ресей, Moscow; Moscow

Andrey Shilov

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Peoples’ Friendship University of Russia named after Patrice Lumumba

Email: sh_andrey_max@mail.ru
ORCID iD: 0009-0000-7966-9708

Graduate Student, Assistent, Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute

Ресей, Moscow; Moscow

Nadezhda Kozyrina

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: nad-kozyrina@yandex.ru
ORCID iD: 0000-0001-5134-0054

Cand. Med. Sci., Senior Researcher, Department of Epidemiology and Prevention of AIDS

Ресей, Moscow

Anna Popova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Russian Medical Academy of Continuous Professional Education

Email: popova@cmd.su
ORCID iD: 0000-0001-9484-5917

Cand. Med. Sci., Senior Researcher, Associate Professor, Department of Infectious Diseases

Ресей, Moscow; Moscow

Veronika Kanestri

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: kanestri@yandex.ru
ORCID iD: 0000-0002-2234-7094

MD, Senior Researcher, Infectiologist

Ресей, Moscow

Marina Goliusova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: mad2501@yandex.ru
ORCID iD: 0000-0002-5325-6857

Infectiologist

Ресей, Moscow

Alexey Kravchenko

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: alexey-kravtchenko@yandex.ru
ORCID iD: 0000-0001-7857-3763

MD, Leading Researcher

Ресей, Moscow

Әдебиет тізімі

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