CLINICAL AND EPIDEMIOLOGICAL FEATURES OF ENTEROVIRUS MENINGITIDES IN CHILDREN IN THE ORENBURG REGION

The paper gives the results of examining the clinical and epidemiological features of enterovirus meningitides (EVM) in children in the Orenburg Region in 2006-2011, by using the records available in the Board, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare in the Orenburg Region, and analyzing 90 EVM cases in the children treated in an Orenburg municipal city clinical infectious diseases hospital and followed up for 12 months. EVM has been found to take the lead in the pattern of the clinical forms of enterovirus infection in children. There are dominant groups of EVM pathogens: ЕСНО viruses (serotypes 6, 9, 19, and 30); the most vulnerable age groups: children aged 7-14 (51.4%) and 3-6 (27.1%) years; the clinical features of EVM and outcomes in children treated and untreated with wiferon as part of basic therapy. There is a preponderance of its severe forms (93%) with the development of functional impairments of the central nervous system: cerebrasthenic (36%) and neurosis-like (27%) syndromes persisting within 12 months in one third of the children untreated with wiferon. The use of this drug reduced the time of regression of the major clinical syndromes of EVM and the risk of neurological disorders in the convalescent period. Thefindings provide a rationale for the expediency of incorporating wiferon into the combination basic therapy for EVM in children.

enterovirus meningitis, children, clinic, antiviral therapy, outcomes