THE HIV NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS ABACAVIR AND LAMIVUDINE IN FIRST-LINE ANTIRETROVIRAL THERAPY REGIMENS
- Authors: KRAVCHENKO A.V1, KANESTRI V.G1
-
Affiliations:
- Federal Scientific-and-Methodic Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow
- Issue: No 2 (2011)
- Pages: 49
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/287267
- ID: 287267
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Abstract
The review gives the results of a few large trials (CNA 30024, HEAT, STEAL, BICOMBO, ACTG 5202, ACTG 5224s, SWIFT, ASSERT) of the efficacy and safety of antiretroviral therapy (ARVT) regimens incorporating the HIV nucleoside reverse transcriptase inhibitors (NRTIs) abacavir and lamivudine. W hen ARVT regimens are used today, the fixed-dose combinations of NRTIs (Combivir ® , Kivexa ® , Truvada ® ) have certain benefits of reducing the number of drugs and the frequency of their administration. Since Kivexa and Truvada have a comparable virological efficacy and a good tolerability, they are included into first-line ARVT regimens as recommended in most current guidelines. When a patient is given an abacavircontaining ARVT regimen, he/she should have genetic testing for the HLA-B*5701 allele in order to minimize a risk for developing a hypersensitivity reaction (near 100% negative predictive value). On choosing the optimal first-line ARVT regimen for a specific patient, the physician should consider the whole spectrum of possible adverse reactions, comorbidity, drug interactions, and the living conditions of a HIV-infected patient.
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About the authors
A. V KRAVCHENKO
Federal Scientific-and-Methodic Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow
Email: kravtchenko@hivrussia.net
V. G KANESTRI
Federal Scientific-and-Methodic Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow
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