EVOLUTION OF PRESENT-DAY SALMONELLOSES IN CHILDREN: TOPICAL PROBLEMS AND TRENDS

A long-term (more than 30-year) follow-up of salmonellosis in hospitalized children showed a rise in its morbidity and a preponderance of S. enteritidis; a tendency to lower the incidence ofsevere forms of the disease in all age groups; its course with concomitant rotaviris infection (in a third of the children); a variation in drug resistance among the predominant S. enteritidis with the its rise in 2005-2007 and the emergence of multiresistant strains (28.9%), which resulted in the lower efficiency ofetiotropic therapy; and the frequency of long-term postinfection bacterial carriage (1,5-9 months in a third of the children). Ways to optimize therapy with third-generation cephalosporins in the acute period of the disease and immunomodulatory therapy were defined for patients with long-term postinfection bacterial excretion.

salmonellosis, children, drug resistance, long-term postinfection bacterial excretion, cephalosporins, licopid