Anogenital human papillomavirus infection in HIV-infected women (according to the results of a pilot study in the Moscow Region)


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. To investigate the prevalence of high-risk human papillomavirus (hrHPV), by simultaneously examining biological materials from the cervical canal and anus of HIV-infected women. Subjects and methods. The investigation enrolled 101 HIV-infected women living in Moscow and the Moscow Region. Real-time PCR was used to determine hrHPV in a scrape from the cervical canal and anus. Results. Testing the samples from the cervical canal and anus revealed the high prevalence of hrHPV (60.4%): it was 72.1% and 78.7% the scrapes of epithelial cells in the cervical canal and anus, respectively. At the same time, HPV infection in the cervical canal and anus was recorded in 50.8% of cases; an isolated anal lesion was observed in 27.9% of cases. Simultaneous diagnosis of human papillomavirus infection in the two studied loci indicated that in 67.7% of cases, the anal scrape contained hrHPV genotypes that were absent in the cervical scrape. The ratio of the detected hrHPV genotypes varies substantially with the studied locus. More than one hrHPV genotype was detected in 56.3% of the anal samples, whereas only one genotype was found in 65.9% of the cervical samples. Conclusion. The high detection rate of hrHPV DNA in the epithelial cells of the cervical canal and anus of HIV-infected women, as well as a broad range of detectable hrHPV genotypes demonstrate the need for the screening for precancerous diseases of the cervix and anus, which is based on HPV testing with the determination of 14 hrHPV genotypes.

Толық мәтін

Рұқсат жабық

Авторлар туралы

A. Popova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: asya-med@mail.ru

Elvira Domonova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: lvira.domonova@pcr.ms
Cand. Biol. Sci., Head, Scientific Group for New Methods to Diagnose Opportunistic and Human Papillomavirus Infections, Department of Molecular Diagnosis and Epidemiology

Nadezhda Vinogradova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: klimova@cmd.su
Junior Researcher

Olga Shipulina

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: olga.shipulina@pcr.ms
Cand. Med. Sci., Head, Subdivision for Molecular Diagnostic Methods, Department of Molecular Diagnosis and Epidemiology

Әдебиет тізімі

  1. Valvo F., Ciurlia E., Avuzzi B., Doci R., Ducreux M., Roelofsen F. et al. Cancer of the anal region. Crit. Rev. Oncol. Hematol. 2019; 135: 11527. doi: 10.1016/j.critrevonc.2018.12.007
  2. Godfrey C., Firnhaber C.S., D’Souza G., Heard I. Anal dysplasia in HIV-infected women: a commentary on the field. International Journal of STD and AIDS 2017; 28(6): 543-549. https://doi.org/10.1177/0956462415615764
  3. Hessol N.A., Whittemore H., Vittinghoff E. et al. Incidence of first and second primary cancers diagnosed among people with HIV, 1985-2013: a population-based, registry linkage study. Lancet HIV 2018. [PMID: 30245004]. doi: 10.1016/S2352-3018(18)30179-6
  4. Mallari A.O., Schwartz T.M., Luque A.E. et al. Anal cancer screening in HIV-infected patients: is it time to screen them all? Dis. Colon. Rectum. 2012; 55(12): 1244-1250. doi: 10.1097/DCR.0b013e31826ab4fb
  5. Silverberg M.J., Lau B., Justice A.C. et al. Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America. Clin. Infect. Dis. 2012; 54(7): 1026-1034. doi: 10.1093/cid/cir1012
  6. Baranoski A.S., Tandon R., Weinberg J. et al. Risk factors for abnormal anal cytology over time in HIV-infected women. Am. J. Obstet. Gynecol. 2012; 207(2): 107: e1-c8. doi: 10.1016/j. ajog.2012.03.030
  7. Ramamoorthy S., Luo L., Luo E. et al. Tobacco smoking and risk of recurrence for squamous cell cancer of the anus. Cancer Detect Prev. 2008; 32(2): 116-120. doi: 10.1016/j. cdp.2008.04.004
  8. Bowzyk Al-Naeeb A., Barnett G., Wilson C. Smoking and the risk of anal cancer recurrence: The Addenbrookes Hospital experience. J. Clin. Oncol. 2014; 32(3 suppl): 439.
  9. van der Snoek E.M., van der Ende M.E., den Hollander J.C. et al. Use of highly active antiretroviral therapy is associated with lower prevalence of anal intraepithelial neoplastic lesions and lower prevalence ofhuman papillomavirus in HIVinfected men who have sex with men. Sex Transm Dis. 2012; 39(7): 495-500. doi: http://dx.doi.org/10.1097/OLQ.0b013e31825aa764
  10. Palefsky J.M., Holly E.A., Ralston M.L. et al. Prevalence and risk factors for anal human papillomavirus infection in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women. J. Infect. Dis. 2001; 183(3): 383-391. doi: 10.1086/318071
  11. Stier E.A., Lensing S.Y., Darragh T.M. et al. Prevalence of and Risk Factors for Anal High-grade Squamous Intraepithelial Lesions in Women Living with Human Immunodeficiency Virus. Clin. Infect. Dis. 2020; 70(8): 1701-1707. doi: 10.1093/cid/ciz408
  12. Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents. Last Updated: November 29, 2018. http://aidsinfo.nih.gov/guidelines
  13. Gaisa M., Ita-Nagy F., Sigel K. et al. High rates of anal high-grade squamous intraepithelial lesions in HIV-infected women who do not meet screening guidelines. Clin. Infect. Dis. 2017; 64(3): 289-294. doi: 10.1093/cid/ ciw729
  14. Покровский В.В., Беляева В.В., Ермак Т.Н., Зимина В.Н., Канестри В.Г., Козырина Н.В. и др. (ред.). ВИЧ-инфекция и СПИД. Клинические рекомендации. М.: ГЭОТАР-Медиа, 2019. ISBN 978-5-9704-4869-4
  15. Попова А.А., Шипулина О.Ю., Алмамедова Э.А., Рзаева А.М., Кадырова А.А., Григорян С.Р. и др. Вирус папилломы человека высокого канцерогенного риска у ВИЧ-инфицированных женщин в странах Восточной Европы и Центральной Азии. Клиническая дерматология и венерология 2019; 18(1): 84-90. https://doi.org/10.17116/klinderma20191801184
  16. Шипулина О.Ю., Попова А.А., Кравченко А.В., Деулина М.О., Дмитрюкова М.Ю., Романюк Т.Н. Распространение высокоонкогенных генотипов вируса папилломы человека у ВИЧ-позитивных и ВИЧ-негативных женщин. Инфекционные болезни 2016; 14(4): 26-30. doi: 10.20953/1729-9225-2016-4-26-30
  17. Clifford G.M., Goncalves M.A., Franceschi S. et al. Human papillomavirus types among women infected with HIV: a metaanalysis. AIDS 2006; 20(18): 2337-2344. doi: 10.1097/01.aids.0000253361.63578.14
  18. Castilho J.L., Levi J.E., Luz P.M. et al. A cross-sectional study of high-risk human papillomavirus clustering and cervical outcomes in HIV-infected women in Rio de Janeiro, Brazil. BMC Cancer 2015; 15: 478. doi: 10.1186/ s12885-015-1486-4

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Bionika Media, 2021

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>