MANIFESTATIONS OF THE EPIDEMIC PROCESS OF MENINGOCOCCAL INFECTION IN THE OMSK REGION

  • Autores: ANPILOVA N.G.1, KOROLEVA I.S2,3, STASENKO V.L4, VAITOVICH M.A1
  • Afiliações:
    1. Board, Inspectorate for the Protection of Consumer Rights and Human Welfare in the Omsk Region
    2. Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
    3. Russian Reference Center for Bacterial Meningitis Monitoring
    4. Omsk State Medical Academy, Ministry of Health of Russia
  • Edição: Nº 2 (2013)
  • Páginas: 21-26
  • Seção: Articles
  • URL: https://journals.eco-vector.com/2226-6976/article/view/276532
  • ID: 276532

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Resumo

Objective — to assess the epidemic situation of meningococcal infection in the Omsk Region. The incidence of generalized meningococcal infection (GMI) was retrospectively analyzed on the basis of its 726 notified cases. A total of 3057 serum samples taken from apparently healthy individuals in 2006—2011 were examined. Multilocus sequence typing meningococci was carried out in the Russian Reference Center for Bacterial Meningitis Monitoring: 8 Neisseria meningitidis strains were investigated. The incidence of GMI showed a marked downward trend in the Omsk Region in the last 13 years. The proportion of Neisseria meningitidis serogroups B (NMB) and C (NMC) were equal in the etiological structure of GMI; NMB constituted the highest proportion (52.0%) in the structure of deaths. Evaluation of meningococcal immunity revealed that specific antibodies in the protective titers against N. meningitidis serogroup A (NMA) and NMC were present in 4.8% and 0.7%, respectively, which was indicative of the low circulation of the above serogroups in the Omsk Region. A unique NMA strain with the sequence type ST- 7639, which was not included in any of the known clonal complexes, was found. In the Omsk Region, the cases of meningococcal infection are sporadic and suggest an interepidemic period pattern. NMB and NMC were ascertained to be of great importance in the incidence of GMI, suggesting the significance of microbiological monitoring in the epidemiological infection surveillance system. The use of current methods for pathogen identification could reveal new NMA strains circulating in the Omsk Region.

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Sobre autores

Natalia ANPILOVA

Board, Inspectorate for the Protection of Consumer Rights and Human Welfare in the Omsk Region

Email: epidotdel@55.rospotrebnadzor.ru

I. KOROLEVA

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare; Russian Reference Center for Bacterial Meningitis Monitoring

Email: rocmi@pcr.ru

V. STASENKO

Omsk State Medical Academy, Ministry of Health of Russia

Email: vlstasenko@yandex.ru

M. VAITOVICH

Board, Inspectorate for the Protection of Consumer Rights and Human Welfare in the Omsk Region

Email: vaytovich@55.rospotrebnadzor.ru

Bibliografia

  1. Control ECfDPa. Annual epidemiological report 2011— Reporting on 2009 surveillance data and 2010 epidemic intelligence data. Euro Surveill. 2011; 16(45): 20012.
  2. Harrison L.H., Trotter C.L., Ramsay M.E. Global epidemiology of meningococcal disease. Vaccine 2009; 27 (Suppl. 2): B51—B63.
  3. Leimkugel J., Racloz V., Jacintho da Silva L. Pluschke G. Global review of meningococcal disease. A shifting etiology. J. Bacteriol. Res. 2009; 1(1): 6—18.
  4. Rouphael N.G., Stephens D.S. Neisseria meningitidis: biology, microbiology, and epidemiology. Methods Mol. Biol. 2012; 799: 1—20.
  5. Stephens D.S., Greenwood B., Brandtzaeg P. Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet 2007; 369(9580): 2196—2210.
  6. Миронов К.О., Шипулин Г.А., Королева И.С., Платонов А.Е. Генотипирование Neisseria meningitidis. Эпидемиол. и инфекц. бол. 2009; (4): 18—21.
  7. Brehony C., Jolley K. A., Maiden M. C. Multilocus sequence typing for global surveillance of meningococcal disease. FEMS Microbiol. Rev. 2007; 31 (1): 15—26.
  8. Caugant D. A., Maiden M. C. Мeningococcal carriage and disease — population biology and evolution. Vaccine 2009; 27 (2): 64—70.
  9. Cohn A.C., MacNeil J.R., Harrison L.H. Changes in Neisseria meningitidis disease epidemiology in the United States, 1998—2007: implications for prevention of meningococcal disease. Clin. Infec.t Dis. 2010; 50(2): 184—191.
  10. Racloz V.N. Silva L.J. The elusive meningococcal meningitis serogroup: a systematic review of serogroup B epidemiology. BMC Infect. Dis. 2010; 10(1): 175.
  11. Королева И.С, Белошицкий Г.В., Спирихина Л.В., Грачева А.М., Закроева И.М., Тагаченкова Т.А. и др. Основные направления и результать научньїх исследований по проблеме менингококковой инфекции и гнойньх бактериальньх менингитов. Эпидемиол. и инфекц. бол. 2009; (2): 40—44.
  12. Hedman A.K. Genome-wide transcriptional profiling of Neisseria meningitidis in ex vivo models of septicaemia : a thesis presented for the degree of Doctor of Philosophy of Imperial College of London. London, 2009. 416 p.
  13. Огарков П.И., Белов А.Б., Коротченко С.И., Харченко В.И. Пути совершенствования эпидемиологического надзора за менингококковой инфекцией и ее селективная профилактика в войсках. Воен.-мед. журн. 2009; (8): 55—61.
  14. Лабораторная диагностика менингококковой инфекции и гнойних бактериальних менингитов. Метод. указания МУК 4.2.1887-04. М., 2005.

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