LIPID PEROXIDATION AND NONENZYMATIC ANTIOXIDATIVE SYSTEM IN CHILDREN WITH PSEUDOTUBERCULOSIS

Objective. To investigate lipid peroxidation (LPO) processes and a non-enzymatic antioxidant system in children with acute pseudotuberculosis (PT) to predict its outcome. Subjects and methods. 139 pediatric patients aged 10.63±0.63 years with acute PT were examined and divided into 4 groups according to their health status and the severity and pattern of the disease. A control group comprised 45 healthy children. LPO indicators (levels of dienic conjugates and thiobarbituric acid reactive products), plasma concentrations of vitamins E and A, and red blood cell levels of reduced glutathione were studied. Results. LPO activation was established at peak PT in all the children and in early convalescence in patients with an uneven disease course as compared to the respective indicators in the control group. Simultaneously, there was an increase in peroxide hemolysis of red blood cells and decreases in the concentration of antioxidant vitamins E and A and in the level of reduced glutathione in the red blood cells. The degree of impairment corresponded to the severity of the disease. In the patients with an uneven disease course, the indicators studied recovered more slowly than in those with an even one.

children, pseudotuberculosis, lipid peroxidation indicators, vitamins E and A, reduced glutathione