OXIDATIVE STRESS AND ANTIOXIDANT SYSTEMS IN ACUTE BACTERIAL DYSENTERY
- Autores: TAGIROVA Z.G1
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Afiliações:
- Dagestan State Medical Academy
- Edição: Nº 1 (2016)
- Páginas: 48-51
- Seção: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/278389
- ID: 278389
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Resumo
Free radical oxidation is an important pathogenetic factor in inflammation. To protect cells against the effects of free radicals, the body forms a set of defense mechanisms, which is customary to be designated as an antioxidant system. Among the tissue antioxidants, there are prominent thiols, the sulfhydryl (SH-) groups of which are able to be oxidized at a high rate to disulfide (SS-) ones, which governs their antiradical activity. The investigation has established that in acute dysentery there is a significant decrease in the level of SH-groups and thiol disulfide coefficient with an increase in the content of SS-groups. The above changes correlate with the severity of the infectious process; there is a breakdown of antioxidant systems in severe dysentery, which appears as thiol sulfide coefficient inversion. The findings substantiate that it is expedient to incorporate antioxidant drugs into the combination therapy of dysentery.
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