Choice of treatment tactics in patients with acute bacterial intestinal infections who have a high risk of developing irritable bowel syndrome

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Objective. A comprehensive assessment of the effect of calcium butyrate (CB) and inulin (I) on reducing the risk of developing post-infectious irritable bowel syndrome (IBS) in patients with acute bacterial intestinal infections (ABIIs) with a high risk of its development in the period of convalescence.

Materials and methods. The study included 60 patients with ABIIs aged 18 to 60 years who had a high risk of developing IBS, established using a discriminant equation that included triglyceride, cholesterol and urea levels at the height of the disease. Patients were randomized into 2 groups of 30 individuals each: in the comparison group, standard therapy was prescribed; in the main group, patients additionally received the biologically active dietary supplement zakofalk (250 mg CB and 250 mg I). The effectiveness of therapy was assessed by the triglyceride levels at the height of the disease and at discharge from hospital, fecal calprotectin and I-FABP levels at the height of the disease and 1 month after after discharge.

Results. There were no statistically significant intergroup differences in the duration of the main clinical symptoms and laboratory parameters. However, the fecal calprotectin and I-FABP levels decreased statistically after 1 month after hospital treatment in the main group. Triglyceride levels were also lower during the recovery period in patients of the main group. Incidence of IBS development over the next 6 months was 38.5 times lower in the group receiving BC + I compared with patients receiving standard therapy.

Conclusion. The use of BC + I in addition to standard therapy accelerates the normalization of inflammatory markers and reduces the risk of developing IBS after ABIIs. A biologically active dietary supplement containing BC + I can be considered as an effective mean of preventing the development of IBS in patients with ABII.

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Sobre autores

Roza Tlyustangelova

Medical Institute, Maikop State Technological University

Autor responsável pela correspondência
Email: tlyustangelova76@mail.ru
ORCID ID: 0000-0002-9926-3964

Assistant, Department of Infectious Diseases

Rússia, Maikop

Natalia Pshenichnaya

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; M. F. Vladimirsky Moscow Regional Research Clinical Institute

Email: natalia-pshenichnaya@yandex.ru
ORCID ID: 0000-0003-2570-711X

Professor, MD, Deputy Director for Clinical and Analytical Work, Professor at the Department of Infectious Diseases

Rússia, Moscow; Moscow

Irina Lizinfeld

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: irinalizinfeld@gmail.com
ORCID ID: 0000-0002-8114-1002

Cand. Med. Sci., Consultant, Organizational and Methodological Department

Rússia, Moscow

Andrey Zhuravlev

M. F. Vladimirsky Moscow Regional Research Clinical Institute

Email: zhuravlev_and@inbox.ru
ORCID ID: 0000-0002-9130-707X

Junior Researcher, Department of X-ray Endovascular Surgery, Department of Endovascular Treatment of Cardiovascular Diseases and Arrhythmias

Rússia, Moscow

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2. Fig. 1. ROC-curve characterizing the dependence of the prognosis of IBS after ABII on the value of the logistic function P

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