ПРОЯВЛЕНИЕ ВОСПАЛИТЕЛЬНОГО СИНДРОМА ВОССТАНОВЛЕНИЯ ИММУННОЙ СИСТЕМЫ НА ФОНЕ АНТИРЕТРОВИРУСНОЙ ТЕРАПИИ У БОЛЬНЫХ ВИЧ-ИНФЕКЦИЕЙ


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Обзор посвящен анализу международного опыта клинических наблюдений развития различных вторичных инфекционных заболеваний на фоне начала успешной антиретровирусной терапии у пациентов с ВИЧ-инфекцией и названного воспалительным синдромом восстановления иммунной системы (ВСВИС) (immune reconstitution inflammatory syndrome - IRIS). Представлены данные клинических исследований по изучению звеньев патогенеза, приводящих к развитию ВСВИС и частоте его встречаемости, в зависимости от исходного количества CD4+-лимфоцитов; рассмотрены клинико-лабораторные критерии для туберкулезассоциированного ВСВИС; охарактеризованы клинические проявления наиболее часто встречаемых вторичных заболеваний, развившихся как проявление ВСВИС; обсуждены современные представления о тактике ведения этой категории пациентов.

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Алексей Викторович КРАВЧЕНКО

ФГУН ЦентральныйНИИ эпидемиологии Роспотребнадзора

Email: kravtchenko@hivrussia.net
д-р мед. наук, проф., вед. науч. сотр.СНИЛ эпидемиологии и профилактики СПИД

Вера Николаевна ЗИМИНА

ГУ Центральный НИИ туберкулеза РАМН

канд. мед. наук, докторант

Ирина Борисовна ВИКТОРОВА

ГОУ ДПО Новокузнецкий государственный институт усовершенствования врачей Минздравсоцразвития России

канд. мед. наук, ассистент каф. фтизиопульмонологии

Юлия Равильевна СИТДЫКОВА

ГОУ ВПО Первый МГМУ им. И.М. Сеченова

канд. мед. наук, зав. лаб. вторичных заболеваний ВИЧ-инфекции клиники фтизиопульмонологии

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