STUDY OF VIRAL LOAD AND IMMUNE PARAMETERS IN WOMEN WITH CHRONIC HBV INFECTION IN THE THIRD TRIMESTER OF PREGNANCY
- 作者: KOVALEVA T.A.1, CHUIKOVA K.I1
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隶属关系:
- Siberian State Medical University, Ministry of Health of Russia
- 期: 编号 3 (2013)
- 页面: 17-22
- 栏目: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/276794
- ID: 276794
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详细
Objective. To study viral load and immune parameters in women with chronic hepatitis B (CHB) in the third trimester of pregnancy. Subjects and methods. Fifty women with CHB at 28—36 weeks’ gestation were examined. Results. Chronic HBV infection presenting with predominantly HBeAg-negative hepatitis in the pregnant women was found to be accompanied in the third trimester by rare cytolytic exacerbations, higher viral load, lower values of Thelper cells and immunoregulatory index, increases in activated T lymphocytes, natural killer cells and circulating immune complexes, their positive correlation with ALT and AST levels, an elevation in IgG and their positive correlation with IgA and IgM levels. Conclusion. Viral load in pregnant women with CHB in the third trimester is characterized by stable moderate positive correlations with T lymphocyte levels and negative correlations with the count of natural killer cells.
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作者简介
Tatyana KOVALEVA
Siberian State Medical University, Ministry of Health of Russia
Email: kta1209@mail.ru
Tomsk
K. CHUIKOVA
Siberian State Medical University, Ministry of Health of Russia
Email: kirainf@elefot.tsu.ru
Tomsk
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