STUDY OF VIRAL LOAD AND IMMUNE PARAMETERS IN WOMEN WITH CHRONIC HBV INFECTION IN THE THIRD TRIMESTER OF PREGNANCY
- Authors: KOVALEVA T.A.1, CHUIKOVA K.I1
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Affiliations:
- Siberian State Medical University, Ministry of Health of Russia
- Issue: No 3 (2013)
- Pages: 17-22
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/276794
- ID: 276794
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Abstract
Objective. To study viral load and immune parameters in women with chronic hepatitis B (CHB) in the third trimester of pregnancy. Subjects and methods. Fifty women with CHB at 28—36 weeks’ gestation were examined. Results. Chronic HBV infection presenting with predominantly HBeAg-negative hepatitis in the pregnant women was found to be accompanied in the third trimester by rare cytolytic exacerbations, higher viral load, lower values of Thelper cells and immunoregulatory index, increases in activated T lymphocytes, natural killer cells and circulating immune complexes, their positive correlation with ALT and AST levels, an elevation in IgG and their positive correlation with IgA and IgM levels. Conclusion. Viral load in pregnant women with CHB in the third trimester is characterized by stable moderate positive correlations with T lymphocyte levels and negative correlations with the count of natural killer cells.
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About the authors
Tatyana A. KOVALEVA
Siberian State Medical University, Ministry of Health of Russia
Email: kta1209@mail.ru
Tomsk
K. I CHUIKOVA
Siberian State Medical University, Ministry of Health of Russia
Email: kirainf@elefot.tsu.ru
Tomsk
References
- Всемирная организация здравоохранения. Центр СМИ. Информационный бюллетень № 204. Гепатит В. URL: http://www.who.int/mediacentre/factsheets/fs204/ ru/index.html просмотрено 04.12.2012.
- О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2011 году: Государственный доклад. М.: Федеральный центр гигиены и эпидемиологии Роспотребнадзора, 2012. 316 с.
- О санитарно-эпидемиологической обстановке в Российской Федерации в 2010 году: Государственный доклад. М.: Федеральный центр гигиены и эпидемиологии Роспотребнадзора, 2011. 431 с.
- Горячева Л.Г. НВ- и НС-вирусные инфекции у детей, инфицированных в раннем возрасте. Автореф. дис.. д-ра мед. наук. СПб, 2005.
- Guo Y., Liu J., Meng L. et al. Survey of HBsAg-positive pregnant women and their infants regarding measures to prevent maternal-infantile transmission. BMC Infect. Dis. 2010; 10:26. doi: 10.1186/1471-2334-10-26.
- Han G.-R., Xu C.-L., Zhao W., Yang Y.-F. Management of chronic hepatitis B in pregnancy. World J. Gastroenterol. 2012; 18 (33): 4517-4521.
- Ковалева Т.А., Чуйкова К.И., Алексеева Е.А. Эпидемиологическая характеристика хронических вирусных гепатитов В и С у беременных женщин на территории Томской области. Эпидемиол. и вакцинопроф. 2011; 3 (58): 38—42.
- Chisari F.V., Isogawa M., Wieland S.F. Pathogenesis of hepatitis B virus infection. Pathol. Biol. (Paris) 2010; 58 (4): 258-266.
- Borgia G., Carleo M.A., Gaeta G.B., Gentile I. Hepatitis B in pregnancy. World J. Gastroenterol. 2012; 18 (34): 4677—4683.
- Zhang W.L., Zhao J., Li W. [Influencing factors of mother-infant vertical transmission of hepatitis B virus]. Zhongguo Dang Dai Er Ke Za Zhi 2011; 13 (8): 644-646.
- Хаитов Р.М., Пинегин Б.В., Ярилин А.А. Руководство по клинической иммунологии. Диагностика заболеваний иммунной системы. М.: ГЭОТАР-Медиа, 2009. 352 с.
- Tan G., Zhao W., Liu X. et al. Immunophenotypic profile of intrahepatic and circulating lymphocytes in chronic hepatitis B patients. Hepatogastroenterology 2012; 59(117): 1516—1521.
- Vivier E., Tomasello E., Baratin M. et al. Functions of natural killer cells. Nat. Immunol. 2008; (9): 503—510.
- Fisicaro Р., Valdatta C., Boni C. et al. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut 2009; 58 (7): 974-982.
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