FEATURES OF THE CLINICAL COURSE AND THE COVID-19 EPIDEMIC PROCESS IN THE COMMUNITIES OF VARIOUS PLANNING PATTERNS


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Objective. To establish a relationship between the clinical and epidemiological course of COVID-19 and the duration of focal morbidity in the communities of various planning patterns. Materials and methods. In April 15 to June 2, 2020, the investigators carried out a sampling longitudinal prospective analytical study of the course of the clinical and epidemic process in the COVID-19 foci formed in the communities of various planning patterns. There were a total of 515 COVID-19 cases. Results. A direct relationship was found between the clinical course and features of the COVID-19 epidemic process and the duration of focal morbidity in the communities of various planning patterns. The analyzed epidemiological indicators: cumulative incidence, morbidity, and incidence density significantly increased by the second incubation period (from day 14 to day 28 since the date of registration of the first case of COVID-19 in the community). The increase in these indicators characterizing the course of the infectious process of COVID-19 was accompanied by an intensive rise in new infection cases and by a change in the clinical course of the disease. This was manifested by an increase in the total number of registered community-acquired pneumonias and a decrease in the period of their development. The increase in the intensity of the epidemic process, the change in the clinical course of COVID-19 and the timing of the development of community-acquired pneumonia directly depended on the duration of the focal process of COVID-19. The long current focus was established to have lower epidemiological indicators in the separate community compared to the reported one. Conclusion. The long current COVID-19 foci formed in the reported and separate communities are characterized by a more intensive epidemic process; the persons who have got infection in the communities have often a severer clinical course.

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作者简介

Alexander ZADOROSHNYI

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: alezanderzadoroshnyy@yandex.ru
Resident Moscow, Russia

Natalia PSHENICHNAYA

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: natalia-pshenichnaya@yandex.ru
Professor, MD, Deputy Director on Clinical and Analytical Work Moscow, Russia

Vasiliy AKIMKIN

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: vgakimkin@yandex.ru
Professor, MD, Academician of the Russian Academy of Sciences, Director Moscow, Russia

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