Regression of liver fibrosis in patients with chronic hepatitis C after a cycle of therapy with direct-acting antivirals
- 作者: Saranskaya Y.E.1, Kiseleva L.M.1, Sachek A.A.1
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隶属关系:
- Ulyanovsk State University
- 期: 卷 13, 编号 1 (2023)
- 页面: 83-86
- 栏目: Original Investigations
- URL: https://journals.eco-vector.com/2226-6976/article/view/321941
- DOI: https://doi.org/10.18565/epidem.2023.13.1.83–6
- ID: 321941
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详细
Objective. To assess the time course of changes in liver fibrosis (LF) in patients with chronic hepatitis C (CHC) who received a cycle of therapy with direct-acting antivirals.
Subjects and methods. Fifty-nine patients with CHC and different stages of LF, who received therapy with direct-acting antivirals according to different treatment regimens for 8 to 16 weeks, were followed up. In all the patients, the time course of changes in liver tissue fibrosis was retrospectively analyzed based on fibroscanning results. The stage of fibrosis was diagnosed using vibration-controlled transient elastometry; the degree of steatosis was assessed by the controlled attenuation parameter using the FibroScan® 530 Compact device, Echosens (France).
Results. According to the METAVIR scoring system, fibrosis stage F4 was established in 24 (40.7%) patients before the start of antiviral therapy for CHC; it persisted in 7 (11.9%) after the end of treatment.
Conclusion. The findings suggest that the stage of LF is reversed after completion of an antiviral therapy cycle.
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作者简介
Yana Saranskaya
Ulyanovsk State University
编辑信件的主要联系方式.
Email: ms.saranskaya@mail.ru
ORCID iD: 0000-0001-8498-9554
Assistant Lecturer, Department of Infectious and Skin and Venereal Diseases
俄罗斯联邦, UlyanovskLyubov Kiseleva
Ulyanovsk State University
Email: kiseleva.l.m.73@mail.ru
ORCID iD: 0000-0003-1188-7682
MD, Professor, Department of Infectious and Skin and Venereal Diseases
俄罗斯联邦, UlyanovskAnna Sachek
Ulyanovsk State University
Email: sachek.a.15@mail.ru
ORCID iD: 0000-0003-4776-7869
Sixth-Year Student, Faculty of Medicine
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