Epidemiological and clinical and laboratory features of the new coronavirus infection COVID-19 in children of different age groups in Ryazan

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. Study of epidemiological and clinical laboratory features of the new coronavirus infection COVID-19 in children of various age groups permanently residing in Ryazan.

Materials and methods. An analysis of the medical records of 585 patients aged over 1 month up to 17 years of age with a verified diagnosis of new coronavirus infection COVID-19, who were under the follow-up of the local pediatric service of city children’s clinics in Ryazan for the period from March 2020 to December 2021 was carried out.

Results. School-age children accounted for 68.7%. Infection with SARS-CoV-2 in 87.2% of cases occurred as a result of intra-family contact with patients with COVID-19. 71.8% had a mild course of the disease, 5.3% had a moderate course; the diagnosis of «community-acquired pneumonia2» was verified in 4.1% of cases. Premorbid pathology was detected in 8.4% of children; it was 10.7 times more likely to be recorded in children with a moderate course of the disease (p < 0.001). The clinical picture of COVID-19 was dominated by symptoms of intoxication (74.9%) and respiratory tract damage (69.6%). Gastrointestinal manifestations were more common in children aged 0 to 7 years (p < 0.001), dysosmia and dysgeusia – in school-age children (p < 0.001). Asthenic syndrome was noted in 4.7% of children 3 months after new coronavirus infection.

Conclusion. The majority of children had a mild course of coronavirus infection, not requiring hospitalization, with a favorable outcome. Relationships between the severity of coronavirus infection and the presence of concomitant pathology (r = 0.33; p < 0.001), as well as between the age of patients and the presence of gastrointestinal symptoms (r = -0.48; p < 0.001), dysgeusia (r = 0.44; p < 0.001) and dysosmia (r = 0.46; p < 0.001) were established.

全文:

受限制的访问

作者简介

Nataliya Belykh

I.P. Pavlov Ryazan State Medical Pavlov

编辑信件的主要联系方式.
Email: nbelyh68@mail.ru
ORCID iD: 0000-0002-5533-0205

MD, Head, Department of Outpatient Pediatrics with a Course in Pediatrics, Faculty of Additional Professional Education

俄罗斯联邦, Ryazan

Nataliya Anikeeva

I.P. Pavlov Ryazan State Medical Pavlov

Email: natasha782@inbox.ru
ORCID iD: 0000-0003-1103-2019

Cand. Med. Sci., Assistant Professor, Department of Faculty and Outpatient Pediatrics with a Course in Pediatrics, Faculty of Additional Professional Education

俄罗斯联邦, Ryazan

Elizaveta Akimova

City Children’s Clinic № 7

Email: elizaveta.akimova.97@mail.ru
ORCID iD: 0000-0001-8755-0918

Pediatrician

俄罗斯联邦, Ryazan

Anastasia Panferuhina

I.P. Pavlov Ryazan State Medical Pavlov

Email: n.panferuhina@mail.ru
ORCID iD: 0000-0002-6926-2418

Resident

俄罗斯联邦, Ryazan

Inna Piznyur

I.P. Pavlov Ryazan State Medical Pavlov

Email: innaabramova@yandex.ru
ORCID iD: 0000-0002-9267-439X

Teaching Assistant, Department of Faculty and Outpatient Pediatrics with a Course in Pediatrics, Faculty of Additional Professional Education

俄罗斯联邦, Ryazan

Elena Stezhkina

I.P. Pavlov Ryazan State Medical Pavlov

Email: polus1972@yandex.ru
ORCID iD: 0000-0002-1806-0787

Cand. Med. Sci., Assistant Professor, Department of Faculty and Outpatient Pediatrics with a Course in Pediatrics, Faculty of Additional Professional Education

俄罗斯联邦, Ryazan

Nataliya Sharapina

City Children’s Clinic № 7

Email: Gdp7@ryazangov.ru

Head, Pediatric Department

俄罗斯联邦, Ryazan

Nataliya Privalova

City Children’s Clinic № 6

Email: natali-rz@mail.ru

Head, Pediatric Department

俄罗斯联邦, Ryazan

Elena Makarkina

City Children’s Clinic № 3

Email: mak.elena1965@yandex.ru
ORCID iD: 0000-0001-6106-6722

Deputy Chief Medical Officer

俄罗斯联邦, Ryazan

Olga Solovyova

I.P. Pavlov Ryazan State Medical Pavlov

Email: olgasolovejka@yandex.ru
ORCID iD: 0000-0002-7680-7041

Postgraduate Student, Department of Faculty and Polyclinic Pediatrics with a Pediatrics Course at the Faculty of Continuing Professional Education

俄罗斯联邦, Ryazan

参考

  1. Jackson Gregory. COVID-19 and socio-economics. Socio-Economic Review 2021; 19(1): 1–6. https://doi.org/10.1093/ser/mwab030
  2. Johns Hopkins University & Medicine. Coronavirus Resource Center. COVID-19 data in motion. https://coronavirus.jhu.edu/
  3. Dong Y., Mo X., Hu Y., Qi X., Jiang F., Jiang Z. et al. Epidemiology of COVID-19 Among Children in China. Pediatrics 2020; 145(6): e20200702. doi: 10.1542/peds.2020-0702
  4. Белых Н.А., Соловьева О.А., Аникеева Н.А. Эпидемиологические и клинико-лабораторные особенности COVID-19 у пациентов детского возраста. Педиатр 2021; 12(6): 63–76. doi: 10.17816/PED12663-76. Belyh N.A., Solov’eva O.A., Anikeeva N.A. [Epidemiological and clinical and laboratory features of COVID-19 in pediatric patients]. Pediatrician 2021; 12(6): 63–76. (In Russ.). doi: 10.17816/PED12663-76
  5. Toba N., Gupta S., Ali A.Y., ElSaban M., Khamis A.H., Ho S.B. et al. COVID-19 under 19: A meta-analysis. Pediatr Pulmonol. 2021; 56(6): 1332–41. doi: 10.1002/ppul.25312.
  6. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19): Временные методические рекомендации. Министерство здравоохранения Российской Федерации. Версия 15 (22.02.2022) [Prevention, diagnosis and treatment of new coronavirus infection (COVID-19): Interim guidelines. Ministry of Health of the Russian Federation. Version 15 (22.02.2022)]. (In Russ.).
  7. Maltezou H.C., Magaziotou I., Dedoukou X., Eleftheriou E., Raftopoulos V., Michos A. et al. Children and Adolescents With SARS-CoV-2 Infection: Epidemiology, Clinical Course and Viral Loads. Pediatr. Infect. Dis. J. 2020; 39(12): e388-e392. doi: 10.1097/INF.0000000000002899
  8. Centers for Disease Control and Prevention. COVID Data Tracker. Cases, Deathes and Testing. https://covid.cdc.gov/covid-data-tracker/#demographics
  9. Couture A., Lyons B.C., Mehrotra M.L., Sosa L., Ezike N., Ahmed F.S. et al. Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Reported Coronavirus Disease 2019 Cases in US Children, August 2020–May 2021. Open Forum Infect. Dis. 2022; 9(3): ofac044. doi: 10.1093/ofid/ofac044
  10. Havers F.P., Reed C., Lim T., Montgomery J.M., Klena J.D., Hall A.J. et al. Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23–May 12, 2020. JAMA Intern. Med. 2020; Jul 21. doi: 10.1001/jamainternmed.2020.4130
  11. COVID-19: Clinical manifestations and diagnosis in children. https://www.uptodate.com/contents/covid-19-clinical-manifestations-and-diagnosis-in-children?topicRef = 127759&source = see_link
  12. Grijalva C.G., Rolfes M.A., Zhu Y., McLean H.Q., Hanson K.E., Belongia E.A. et al. Transmission of SARS-COV-2 Infections in Households – Tennessee and Wisconsin, April-September 2020. MMWR Morb. Mortal. Wkly. Rep. 2020; 69(44): 1631–4. doi: 10.15585/mmwr.mm6944e1
  13. Macartney K., Quinn H.E., Pillsbury A.J., Koirala A., Deng L., Winkler N. et al. Transmission of SARS-CoV-2 in Australian educational settings: a prospective cohort study. Lancet Child. Adolesc. Health 2020; 4(11): 807–16. doi: 10.1016/S2352-4642(20)30251-0
  14. Vivanti A.J., Vauloup-Fellous C., Prevot S., Zupan V., Suffee C., Do Cao J. et al. Transplacental transmission of SARS-CoV-2 infection. Nat. Commun. 2020; 11(1): 3572. doi: 10.1038/s41467-020-17436-6
  15. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19): Временные методические рекомендации. Министерство здравоохранения Российской Федерации. Версия 14 (27.12.2021). [Ministry of Health of the Russian Federation. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19): Temporary guidelines. Version 14 (27.12.2021)]. (In Russ.).
  16. Calitri C., Fumi I., Ignaccolo M.G., Banino E., Benetti S., Lupica M.M. et al. Gastrointestinal involvement in paediatric COVID-19 – from pathogenesis to clinical management: A comprehensive review. World J. Gastroenterol. 2021; 27(23): 3303–16. doi: 10.3748/wjg.v27.i23.3303
  17. Щедеркина И.О., Овсянников Д.Ю., Глазырина А.А., Ивин Н.О., Бронина Н.В., Кузнецова А.А. и др. Астенический синдром у детей и подростков: выбор терапии. Нервные болезни 2021; (2): 20–7. https://cyberleninka.ru/article/n/astenicheskiy-sindrom-u-detey-i-podrostkov -vybor-terapii. Shhederkina I.O., Ovsjannikov D.Yu., Glazyrina A.A., Ivin N.O., Bronina N.V., Kuznecova A.A. et al. [Asthenic syndrome in children and adolescents: choice of therapy]. Nervous diseases 2021; (2): 20–7. (In Russ.). https://cyberleninka.ru/article/n/astenicheskiy-sindrom-u-detey-ipodrostkov-vybor-terapii
  18. Асфандиярова Н.С., Филиппов Е.В., Дашкевич О.В., Дорошина Н.В., Cучкова Е.И., Shehtmester L.I. Преимущества и недостатки режима самоизоляции в период первой волны коронавирусной инфекции для пациентов с полиморбидной патологией. Российский медико-биологический вестник им. академика И.П. Павлова 2021; 29(3): 364–8. doi: 10.17816/PAVLOVJ79388. Asfandiуarova N.S., Filippov E.V., Dashkevich O.V., Doroshina N.V., Cuchkova E.I., Shehtmester L.I. [Advantages and disadvantages of the self-isolation regime during the first wave of coronavirus infection for patients with polymorbid pathology]. I.P. Pavlov Russian Medical Biological Herald 2021; 29(3): 364–8. (In Russ.). doi: 10.17816/PAVLOVJ79388
  19. Бородай А.А., Тяпкина Д.А., Тяпаева А.Р., Семенова О.Н., Наумова Е.А. Проявления новой коронавирусной инфекции у пациентов с сердечно-сосудистыми заболеваниями, находившихся на амбулаторном лечении. Наука молодых (Eruditio Juvenium) 2022; 10(1): 33–44. https://doi.org/10.23888/ HMJ202210133-44. Borodaj A.A., Tjapkina D.A., Tjapaeva A.R., Semenova O.N., Naumova E.A. [Manifestations of a new coronavirus infection in patients with cardiovascular diseases who were on outpatient treatment]. Science of young (Eruditio Juvenium) 2022; 10(1): 33–44. (In Russ.) https://doi.org/10.23888/ HMJ202210133-44

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2024
##common.cookie##