Epidemiological and clinical and laboratory features of the new coronavirus infection COVID-19 in children of different age groups in Ryazan

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. Study of epidemiological and clinical laboratory features of the new coronavirus infection COVID-19 in children of various age groups permanently residing in Ryazan.

Materials and methods. An analysis of the medical records of 585 patients aged over 1 month up to 17 years of age with a verified diagnosis of new coronavirus infection COVID-19, who were under the follow-up of the local pediatric service of city children’s clinics in Ryazan for the period from March 2020 to December 2021 was carried out.

Results. School-age children accounted for 68.7%. Infection with SARS-CoV-2 in 87.2% of cases occurred as a result of intra-family contact with patients with COVID-19. 71.8% had a mild course of the disease, 5.3% had a moderate course; the diagnosis of «community-acquired pneumonia2» was verified in 4.1% of cases. Premorbid pathology was detected in 8.4% of children; it was 10.7 times more likely to be recorded in children with a moderate course of the disease (p < 0.001). The clinical picture of COVID-19 was dominated by symptoms of intoxication (74.9%) and respiratory tract damage (69.6%). Gastrointestinal manifestations were more common in children aged 0 to 7 years (p < 0.001), dysosmia and dysgeusia – in school-age children (p < 0.001). Asthenic syndrome was noted in 4.7% of children 3 months after new coronavirus infection.

Conclusion. The majority of children had a mild course of coronavirus infection, not requiring hospitalization, with a favorable outcome. Relationships between the severity of coronavirus infection and the presence of concomitant pathology (r = 0.33; p < 0.001), as well as between the age of patients and the presence of gastrointestinal symptoms (r = -0.48; p < 0.001), dysgeusia (r = 0.44; p < 0.001) and dysosmia (r = 0.46; p < 0.001) were established.

Full Text

Restricted Access

About the authors

Nataliya A. Belykh

I.P. Pavlov Ryazan State Medical Pavlov

Author for correspondence.
Email: nbelyh68@mail.ru
ORCID iD: 0000-0002-5533-0205

MD, Head, Department of Outpatient Pediatrics with a Course in Pediatrics, Faculty of Additional Professional Education

Russian Federation, Ryazan

Nataliya A. Anikeeva

I.P. Pavlov Ryazan State Medical Pavlov

Email: natasha782@inbox.ru
ORCID iD: 0000-0003-1103-2019

Cand. Med. Sci., Assistant Professor, Department of Faculty and Outpatient Pediatrics with a Course in Pediatrics, Faculty of Additional Professional Education

Russian Federation, Ryazan

Elizaveta I. Akimova

City Children’s Clinic № 7

Email: elizaveta.akimova.97@mail.ru
ORCID iD: 0000-0001-8755-0918

Pediatrician

Russian Federation, Ryazan

Anastasia Yu. Panferuhina

I.P. Pavlov Ryazan State Medical Pavlov

Email: n.panferuhina@mail.ru
ORCID iD: 0000-0002-6926-2418

Resident

Russian Federation, Ryazan

Inna V. Piznyur

I.P. Pavlov Ryazan State Medical Pavlov

Email: innaabramova@yandex.ru
ORCID iD: 0000-0002-9267-439X

Teaching Assistant, Department of Faculty and Outpatient Pediatrics with a Course in Pediatrics, Faculty of Additional Professional Education

Russian Federation, Ryazan

Elena V. Stezhkina

I.P. Pavlov Ryazan State Medical Pavlov

Email: polus1972@yandex.ru
ORCID iD: 0000-0002-1806-0787

Cand. Med. Sci., Assistant Professor, Department of Faculty and Outpatient Pediatrics with a Course in Pediatrics, Faculty of Additional Professional Education

Russian Federation, Ryazan

Nataliya M. Sharapina

City Children’s Clinic № 7

Email: Gdp7@ryazangov.ru

Head, Pediatric Department

Russian Federation, Ryazan

Nataliya N. Privalova

City Children’s Clinic № 6

Email: natali-rz@mail.ru

Head, Pediatric Department

Russian Federation, Ryazan

Elena P. Makarkina

City Children’s Clinic № 3

Email: mak.elena1965@yandex.ru
ORCID iD: 0000-0001-6106-6722

Deputy Chief Medical Officer

Russian Federation, Ryazan

Olga A. Solovyova

I.P. Pavlov Ryazan State Medical Pavlov

Email: olgasolovejka@yandex.ru
ORCID iD: 0000-0002-7680-7041

Postgraduate Student, Department of Faculty and Polyclinic Pediatrics with a Pediatrics Course at the Faculty of Continuing Professional Education

Russian Federation, Ryazan

References

  1. Jackson Gregory. COVID-19 and socio-economics. Socio-Economic Review 2021; 19(1): 1–6. https://doi.org/10.1093/ser/mwab030
  2. Johns Hopkins University & Medicine. Coronavirus Resource Center. COVID-19 data in motion. https://coronavirus.jhu.edu/
  3. Dong Y., Mo X., Hu Y., Qi X., Jiang F., Jiang Z. et al. Epidemiology of COVID-19 Among Children in China. Pediatrics 2020; 145(6): e20200702. doi: 10.1542/peds.2020-0702
  4. Белых Н.А., Соловьева О.А., Аникеева Н.А. Эпидемиологические и клинико-лабораторные особенности COVID-19 у пациентов детского возраста. Педиатр 2021; 12(6): 63–76. doi: 10.17816/PED12663-76. Belyh N.A., Solov’eva O.A., Anikeeva N.A. [Epidemiological and clinical and laboratory features of COVID-19 in pediatric patients]. Pediatrician 2021; 12(6): 63–76. (In Russ.). doi: 10.17816/PED12663-76
  5. Toba N., Gupta S., Ali A.Y., ElSaban M., Khamis A.H., Ho S.B. et al. COVID-19 under 19: A meta-analysis. Pediatr Pulmonol. 2021; 56(6): 1332–41. doi: 10.1002/ppul.25312.
  6. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19): Временные методические рекомендации. Министерство здравоохранения Российской Федерации. Версия 15 (22.02.2022) [Prevention, diagnosis and treatment of new coronavirus infection (COVID-19): Interim guidelines. Ministry of Health of the Russian Federation. Version 15 (22.02.2022)]. (In Russ.).
  7. Maltezou H.C., Magaziotou I., Dedoukou X., Eleftheriou E., Raftopoulos V., Michos A. et al. Children and Adolescents With SARS-CoV-2 Infection: Epidemiology, Clinical Course and Viral Loads. Pediatr. Infect. Dis. J. 2020; 39(12): e388-e392. doi: 10.1097/INF.0000000000002899
  8. Centers for Disease Control and Prevention. COVID Data Tracker. Cases, Deathes and Testing. https://covid.cdc.gov/covid-data-tracker/#demographics
  9. Couture A., Lyons B.C., Mehrotra M.L., Sosa L., Ezike N., Ahmed F.S. et al. Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Reported Coronavirus Disease 2019 Cases in US Children, August 2020–May 2021. Open Forum Infect. Dis. 2022; 9(3): ofac044. doi: 10.1093/ofid/ofac044
  10. Havers F.P., Reed C., Lim T., Montgomery J.M., Klena J.D., Hall A.J. et al. Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23–May 12, 2020. JAMA Intern. Med. 2020; Jul 21. doi: 10.1001/jamainternmed.2020.4130
  11. COVID-19: Clinical manifestations and diagnosis in children. https://www.uptodate.com/contents/covid-19-clinical-manifestations-and-diagnosis-in-children?topicRef = 127759&source = see_link
  12. Grijalva C.G., Rolfes M.A., Zhu Y., McLean H.Q., Hanson K.E., Belongia E.A. et al. Transmission of SARS-COV-2 Infections in Households – Tennessee and Wisconsin, April-September 2020. MMWR Morb. Mortal. Wkly. Rep. 2020; 69(44): 1631–4. doi: 10.15585/mmwr.mm6944e1
  13. Macartney K., Quinn H.E., Pillsbury A.J., Koirala A., Deng L., Winkler N. et al. Transmission of SARS-CoV-2 in Australian educational settings: a prospective cohort study. Lancet Child. Adolesc. Health 2020; 4(11): 807–16. doi: 10.1016/S2352-4642(20)30251-0
  14. Vivanti A.J., Vauloup-Fellous C., Prevot S., Zupan V., Suffee C., Do Cao J. et al. Transplacental transmission of SARS-CoV-2 infection. Nat. Commun. 2020; 11(1): 3572. doi: 10.1038/s41467-020-17436-6
  15. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19): Временные методические рекомендации. Министерство здравоохранения Российской Федерации. Версия 14 (27.12.2021). [Ministry of Health of the Russian Federation. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19): Temporary guidelines. Version 14 (27.12.2021)]. (In Russ.).
  16. Calitri C., Fumi I., Ignaccolo M.G., Banino E., Benetti S., Lupica M.M. et al. Gastrointestinal involvement in paediatric COVID-19 – from pathogenesis to clinical management: A comprehensive review. World J. Gastroenterol. 2021; 27(23): 3303–16. doi: 10.3748/wjg.v27.i23.3303
  17. Щедеркина И.О., Овсянников Д.Ю., Глазырина А.А., Ивин Н.О., Бронина Н.В., Кузнецова А.А. и др. Астенический синдром у детей и подростков: выбор терапии. Нервные болезни 2021; (2): 20–7. https://cyberleninka.ru/article/n/astenicheskiy-sindrom-u-detey-i-podrostkov -vybor-terapii. Shhederkina I.O., Ovsjannikov D.Yu., Glazyrina A.A., Ivin N.O., Bronina N.V., Kuznecova A.A. et al. [Asthenic syndrome in children and adolescents: choice of therapy]. Nervous diseases 2021; (2): 20–7. (In Russ.). https://cyberleninka.ru/article/n/astenicheskiy-sindrom-u-detey-ipodrostkov-vybor-terapii
  18. Асфандиярова Н.С., Филиппов Е.В., Дашкевич О.В., Дорошина Н.В., Cучкова Е.И., Shehtmester L.I. Преимущества и недостатки режима самоизоляции в период первой волны коронавирусной инфекции для пациентов с полиморбидной патологией. Российский медико-биологический вестник им. академика И.П. Павлова 2021; 29(3): 364–8. doi: 10.17816/PAVLOVJ79388. Asfandiуarova N.S., Filippov E.V., Dashkevich O.V., Doroshina N.V., Cuchkova E.I., Shehtmester L.I. [Advantages and disadvantages of the self-isolation regime during the first wave of coronavirus infection for patients with polymorbid pathology]. I.P. Pavlov Russian Medical Biological Herald 2021; 29(3): 364–8. (In Russ.). doi: 10.17816/PAVLOVJ79388
  19. Бородай А.А., Тяпкина Д.А., Тяпаева А.Р., Семенова О.Н., Наумова Е.А. Проявления новой коронавирусной инфекции у пациентов с сердечно-сосудистыми заболеваниями, находившихся на амбулаторном лечении. Наука молодых (Eruditio Juvenium) 2022; 10(1): 33–44. https://doi.org/10.23888/ HMJ202210133-44. Borodaj A.A., Tjapkina D.A., Tjapaeva A.R., Semenova O.N., Naumova E.A. [Manifestations of a new coronavirus infection in patients with cardiovascular diseases who were on outpatient treatment]. Science of young (Eruditio Juvenium) 2022; 10(1): 33–44. (In Russ.) https://doi.org/10.23888/ HMJ202210133-44

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies