Clinical and laboratory characteristics of Q fever in the Novosibirsk Region
- 作者: Vyazhevich A.N.1,2, Krasnova E.I.1,2, Bondarenko E.I.3, Krinitsyna E.V.3, Khokhlova N.I.1,2, Pozdnyakova L.L.2, Provorova V.V.1,2, Kolpakova T.A.1, Poddubnaya L.V.1
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隶属关系:
- Novosibirsk State Medical University
- City Infectious Diseases Clinical Hospital № 1
- «Vector-Best»
- 期: 卷 14, 编号 2 (2024)
- 页面: 38-44
- 栏目: Original Investigations
- URL: https://journals.eco-vector.com/2226-6976/article/view/635113
- DOI: https://doi.org/10.18565/epidem.2024.14.2.38–44
- ID: 635113
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Objective. Characteristics of clinical symptoms of Q fever and determination of molecular genetic and serological markers of C. burnetii in patients in the Novosibirsk region hospitalized in the early stages with unspecified fever and suspected infectious diseases transmitted by ticks.
Material and methods. 830 patients hospitalized with suspected infectious diseases transmitted by ticks in the spring-summer period 2018–2022 were examined. To confirm the results of PCR analysis, positive samples containing C. burnetii DNA were amplified using fragments of the IS1111 genes and the heat shock protein B gene (htpB), followed by their sequencing. The presence of class G immunoglobulins to C.burnetii in blood serum samples of patients was detected using ELISA.
Results. All patients with Q fever had intoxication syndrome with febrile fever, 86% had hepatitis with mild-to-moderate cytolysis syndrome; 2 (14.3%) patients developed serous meningitis. Pneumonia was diagnosed in 1 (7.1%) case.
Conclusion. Diagnosis of Q fever due to the polymorphism of the clinical course is impossible without laboratory confirmation. Identification of cases of the disease in the Novosibirsk region during a comprehensive clinical and laboratory study dictates the need to include early diagnosis of Q fever in the list of mandatory tests in patients with tick bites, which is of great practical importance for timely and adequate therapy.
全文:
作者简介
Anna Vyazhevich
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
编辑信件的主要联系方式.
Email: dr.anna.oleynik@mail.ru
ORCID iD: 0000-0002-6387-3939
Assistant, Department of Infectious Diseases, Infectious Disease Doctor
俄罗斯联邦, Novosibirsk; NovosibirskElena Krasnova
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
Email: krasnova-inf@list.ru
ORCID iD: 0000-0003-2625-5442
MD, Head, Department of Infectious Diseases, Infectious Disease Doctor
俄罗斯联邦, Novosibirsk; NovosibirskEvgeny Bondarenko
«Vector-Best»
Email: bondarenko_e@vector-best.ru
ORCID iD: 0000-0002-4699-9548
Cand. Med. Sci., Researcher, PCR laboratory
俄罗斯联邦, NovosibirskElvira Krinitsyna
«Vector-Best»
Email: krinitsyna@vector-best.ru
ORCID iD: 0000-0003-3979-6619
Senior Biotechnologist, Department of hepatitis C ELISA
俄罗斯联邦, NovosibirskNatalya Khokhlova
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
Email: talitas@bk.ru
ORCID iD: 0000-0003-4497-3173
Cand. Med. Sci., Associate Professor, Department of Infectious Diseases
俄罗斯联邦, Novosibirsk; NovosibirskLarisa Pozdnyakova
City Infectious Diseases Clinical Hospital № 1
Email: gikb1@nso.ru
Cand. Med. Sci., Doctor of the Highest Qualification Category, Chief Physician
俄罗斯联邦, NovosibirskVeronika Provorova
Novosibirsk State Medical University; City Infectious Diseases Clinical Hospital № 1
Email: provorova.ydif@mail.ru
ORCID iD: 0000-0002-3475-9934
Cand. Med. Sci., Associate Professor, Department of Infectious Diseases, Doctor of the Highest Qualification Category, Infectious Disease Doctor
俄罗斯联邦, Novosibirsk; NovosibirskTatiana Kolpakova
Novosibirsk State Medical University
Email: t.a.Kolpakova@yandex.ru
ORCID iD: 0000-0001-9718-2020
MD, Professor, Department of Phthisiopulmonology
俄罗斯联邦, NovosibirskLyudmila Poddubnaya
Novosibirsk State Medical University
Email: ftizio12@ngs.ru
ORCID iD: 0000-0001-5494-446X
MD, Professor, Department of Phthisiopulmonology
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