STUDY FOR ANXIOLYTIC ACTIVITY OF MICROCAPSULES WITH NEUROLEPTIC ACTION

Abstract

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Purpose of the work was the conduction of comparative pharmacological researches about the anxiolytic action of peroral dosage forms of aphobazolum - traditional pills and worked out excipient with microcapsules. Materials and methods of the study: the level of anxiety was evaluated in the “elevated plus maze” test. The work was conducted using male Wistar rats weighed 220-350 g, which were divided into 3 groups (by 10 units). Animals of intact group received purified water orally at volume of 1 ml. Control group animals were abdominally injected with a solution from the pills of aphobazolum at volume 1 ml (corresponds to 5 mg/kg/24 hours) through a gastric tube. Animals of the experimental group were administered with an excipient at volume 1 ml (corresponds to 5 mg/kg/24 hours). Relevance of the results difference between the groups was evaluated by means of Student’s criterion. Results: experimental animal group showed the increase of consequently visited feeding arms by 38.5% comparing with the intact group, and by 50% comparing with the control group (p<0.05). The experimental animal group we registered a decrease of mistakes by 31.8% in regard to the intact while visiting the non-feeding arms, and the absence of mistakes while visiting the arms, where the feeding had been eaten (p<0.05). Conclusions: we have proved the anxiolytic action of the excipient with microcapsules of aphobazolum in the “elevated plus maze” test. The studies were supported by a grant of the Council for Grants of the President of the Russian Federation MK-3317.2015.7.