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Vol 3, No 1 (2016)

Original papers
Uterine myoma: modem aspects of pathogenesis and treatment (clinical lecture)
Kudrina E.A., Baburin D.V.
Abstract
In the clinical lecture there are considered modern aspects of pathogenesis, risk factors, diagnosis and treatment of uterine myoma - one of the most common diseases in females of reproductive and menopausal age. Among the major pathogenetic mechanisms of the development of uterine myoma the special attention has been paid to gene and chromosomal aberrations, disturbances of carbohydrate and fat metabolism, chronic inflammatory responses. There was emphasized the attention to modern organ-saving methods of the management of uterine myoma with taking in account the clinical course of the disease, probable complications. There are considered possibilities of various modalities of hormonal therapy as preoperative preparation and prevention of recurrences of uterine myoma after the execution of the organ-saving surgery.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(1):4-10
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Lactoferrin and Raman/fluorescent technologies: the role in pathogenesis and the course of the inflammatory diseases of the female reproductive system
Gulenkova D.G., Zuev V.M.
Abstract
In the review there is reflected the new look at the introduction into clinical microbiology new methods of diagnosis (such as Raman/Fluorescence Technology), which made it possible to enlarge micro-ecological investigations. Suppression of the normal vaginal microflora was found to lead to a variety of causes of the pathology of both inflammatory and non-inflammatory genesis. Iron-binding glycoprotein from the family of transferrin (lactoferrin) gives rise to the decrease of the inflammatory response of the body, it can be used in treatment of vulvovaginal candidiasis and bacterial vaginosis.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(1):11-17
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Clinical-morphological features of lobular, nodular and diffuse forms of adenomyosis
Kogan E.A., Paramonova N.B., Shklyar A.A., Fayzullina N.M., Adamyan L.V.
Abstract
The purpose of the study was to investigate clinical, morphological and immunohistochemical features and pathogenetic interrelationship between focal, nodular and diffuse forms of adenomyosis. There was investigated surgical samples of removed uterines and their fragments; patients were divided into 3 groups, the 1st group was consisted of 16 cases with focal adenomyosis, the 2nd - 24 females with nodular form of adenomyosis, the 3rd - 21 female with diffuse form of adenomyosis. All patients were underwent general clinical examination, instrumental and laboratory observation with the aim of the verification of the diagnosis. There were executed macro- and microscopic immunohistochemical investigations of fragments of the tissue from the zone of endometrioid heterotopias, surrounding myometrium and eutopic endometrium. There were used antibodies: Ki-67, PTEN, ER, PR (“DAKO”), p16 (“Roshe”). There was established the significant increase in the expression of proliferation marker Ki-67, in parallel with a decrease in the expression level of PTEN, ER, PR from the focal to the nodular and diffuse forms of adenonomyosis. Thus it seems to be possible to consider focal, nodular and diffuse forms of adenomyosis as forms-phases of adenomyosis, that according both to histological characteristics of adenomyosis and immunohistochemical markers offocal and nodular forms may antedate the diffuse form of adenomyosis, that is also confirmed by the detection of a combination of all of these forms. Diffuse form of adenomyosis can be assumed to have the highest potential for the growth and dissemination of the pathological process in the uterine.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(1):18-22
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Experience in the therapy of iron deficiency anemia in pregnant women
Medvedeva I.N., Khuraseva A.B.
Abstract
There was executed the examination and treatment of 68 pregnant patients with diagnosed mild iron deficiency anemia (IDA) at gestational age from 12th to 34th weeks. There was estimated the efficacy of the combine preparation of iron and trace elements (iron gluconate, copper gluconate, manganese gluconate) in the treatment of IDA. Early detection of IDA, timely prevention and treatment with the use of this preparation allowed to reduce the rate of obstetric and perinatal complications.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(1):23-25
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Diagnosis, treatment and preventive measures in congenital adrenal hyperplasia due to 21-hydroxylase deficiency in patients in adulthood
Molashenko N.V., Sazonova A.I., Troshina E.A.
Abstract
In the article there are presented main approaches to the diagnosis, treatment and follow-up of patients with classical and nonclassical forms of 21-hydroxylase deficiency. The techniques of diagnostic tests and parameters of hormonal indices for the assessment of the adequacy of replacement therapy with glucocorticoids and mineralocorticoids are considered.
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(1):26-32
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Regional obstetric monitoring in the Sverdlovsk region. Innovative tools for reduction of maternal and perinatal mortality rate
Ankudinov N.O., Ababkov S.G., Zil’ber N.A., Zhilin A.V., Kulikov A.V.
Abstract
According to the State program of the Russian Federation «Health care development» till 2020 approved by the decree of the Russian Federation government dated 24.12.2012 N 2511-p, the principle of the cluster approach became the one of the directions of informatization of healthcare. Subsystem perinatal cluster is the continuous monitoring of pregnant women. Its main advantage is the formation of a unified information space of the hospitals in the region that allows you to reliably group out pregnant females according to the risk of complications of pregnancy and childbirth, to determine the routing for all the patients. The goal of the system is a significant improvement of the assistance within a cluster (group), the formation of a standardized approach to the medical care, management of emergency situations in the occurrence of life-threatening conditions, the reduction of maternal and perinatal mortality rate. Computerization of medical care in obstetrics was implemented in the automated system «Program monitoring for pregnant females».
V.F.Snegirev Archives of Obstetrics and Gynecology. 2016;3(1):33-36
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