Vol 18, No 5-6 (2018)

Articles
SYNTHESIS, PROPERTIES, ANTIMICROBIAL ACTIVITY AND MOLECULAR DOCKING ON THE ENZYME of THE HYDROLASE OF S. AUREUS OF N-ACYLSUBSTITUTED DERIVATIVES OF 5-BROMO (3,5-DIBROM) ANTHRANILIC ACIDS
Andryukov K.V., Korkodinova L.M.
Abstract
The rapid increase in the number of bacterial strains resistant to antibacterial medicines poses a threat to world health, for example, S. aureus staphylococcus produces methicillin-resistant strains. Aim. The aim is the synthesis of eight N-acyl-5-bromo (3,5-dibromo) anthranilic acids, the study of properties, the study of antistaphylococcal activity and research of structure-activity using molecular docking of the enzyme of hydrolase S. aureus. Matherials and Methods. The synthesis was performed, the structure with using of 1H-NMR and IR spectra was proved, the antimicrobial activity against S. aureus was investigated. Calculation of physico-chemical descriptors was performed. Molecular docking by the enzyme of the hydrolase S. aureus was carried out. Results. 8 N-acyl substituted derivatives of 5-bromo (3,5-dibromo) anthranilic acids were synthesized. Antimicrobial activity was studied. A molecular docking with respect to the S. aureus hydrolase enzyme was performed. With the use of regression analysis structure-activity studies were performed, graphic diagrams of the binding energy (Be) dependence from the MIC (S. aureus) and the logarithm 1/MIC (S. aureus) were constructed. Four multiple regression equations based on the MIC (S. aureus) from the Be, log Pcalc, pKacalc and pKвcalc were obtained. Conclusions. The correlation analysis showed a strong correlation between the binding energy (Be) over the S. aureus hydrolase enzyme and the anti-staphylococcal activity. Equation No. 2 with the value of the cross-control coefficient with the exception of one, equal to 0,81 is considered most significant.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):6-12
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The densitometric quantitation of barbiturates in the whole blood
Voronin A.V.
Abstract
The aim of the study was the development of quantitation technique of some drugs in whole blood by means of thin-layer chromatography with videodensitometry. The study subject were model samples of whole blood containing barbital, phenobarbital, barbamyl (amobarbital). The identification parameters of drugs by thin-layer chromatography were defined, interferences of blood matrix and other drugs were studied. Limits of detection in blood samples were 600,0 ng/ml (5,0 μg/spot) for barbital, phenobarbital, barbamyl. The chromatogram scanning and processing images calibration models by using videodensitometry computer program were employed for quantitation. The calibration model is described by polynomial (square) regression. The limits of quantitation for different drugs ranges from 1200,0 to 1500,0 ng/ml; accuracy and precision don’t exceed 23%. Conclusion. The quantitation technique of some barbiturtes in whole blood by thin-layer chromatography with videodensitometry was developed. The ranges of quantitation allow to use this technique for forensic chemistry and clinical analitycal toxicology.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):13-16
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THE DEVELOPMENT OF APPROACHES TO STANDARDIZATION OF THE POPULUS NIGRA LEAVES
Kupriyanova E.A., Kurkin V.A.
Abstract
The article studiesthe problems of phytochemical research of Populus nigra L. leaves, which are considered perspective raw material containing flavonoids. The investigation resulted in the determination of the optimal conditions for the extraction of flavonoids in the leaves of Populus nigra: 70% ethyl alcohol as extragent; ratio between raw material and extragent is 1 : 30; extraction time equals 60 min. The method of quantitative determination of the total flavonoids in the leaves of Populus nigra by differential spectrophotometry using the state standard sample of rutin at a wave length of 414 nm was developed. The content of the total flavonoids for Populus nigra leaves varies from 2.04% to 2.99%. The error of a single determination with a 95% confidence probability is 3.21%.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):17-21
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DETERMINATION OF THE ANTIMICROBIAL ACTIVITY OF WATER AND WATER-ALCOHOL EXTRACTS FROM THE HERBS OF MEADOWSWEET AND DROPWORT
Sazanova K.N., Sharipova S.K., Lyamin A.V.
Abstract
In this paper, we present the results of a comparative study of the antimicrobial activity of aqueous and hydroalcoholic extracts from the herb of meadowsweed (Filipendula ulmaria (L.) Maxim.) and the dropwort (Filipendula hexapetala Gilib.). The results of the investigation showed that herbal nfusion of meadowsweed acts against gram-positive bacterium B. cereus, herbal infusion of the dropwort falciparum is active against gram-positive bacteria S. aureus and yeast-like C. albicans fungus. Tinctures (1 : 5) from the herb of both species o showed less pronounced activity as compared to herbal infusions.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):22-26
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STUDY ON THE ANTIMICROBIAL ACTIVITY OF the THICK SALVIA OFFICINALIS LEAF EXTRACT IN COMBINATION WITH VARIOUS SUBSTANCES IN ORDER TO MAKE A MEDICINE FOR APPLYING IN GYNECOLOGY
Perederii Y.A., Yunusova I.A.
Abstract
Relevance. Infectious and inflammatory diseases of genitals is one of the factors that deteriorate female reproductive health. The treatment is aimed at eradication of pathogenic flora, resolution of infection and prevention of delayed sequela. Currently natural antimicrobial substances in intravaginal dosage forms has become an alternative for the use of chemical antibacterial topical products. Aim. The purpose of this study was to obtain data on the antimicrobial activity of Salvia officinalis leaf extract of various concentrations and in combination with various substances for further substantiation of the vaginal suppositories’ formulation used in gynecological practice. Materials and methods. The antimicrobial activity of the samples has been studied by the conventional procedure in microbiological practice by agar well diffusion method. Specimens were solutions of Salvia officinalis leaf extract in the concentration from 0.25% to 1.25% (table). Standard mixtures of Salvia officinalis leaf extract with 1% and 0.5% solutions of citric and benzoic acids in various combinations have been also used. Results. The enhancement of antimicrobial activity has been noted by means of increasing the extract concentration in the solution. However, an increase of reactant concentration of more than 1% is impractical as the increase in the antimicrobial effect is insignificant. Taking into account the standard mixtures of Salvia officinalis leaf extract with 1% and 0.5% solutions of citric and benzoic acids in various combinations, it has been found that the sample which includes 1% solutions of Salvia officinalis leaf extract, citric and benzoic acids has the highest possible antimicrobial and antifungal activity. Conclusions. The optimal concentrations of active substances for applying in the formulation of vaginal suppositories in order to achieve the highest possible antimicrobial and antifungal activity have been determined.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):27-31
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THEORETICAL BASICS AND THE BACKGROUND OF THE DEVELOPMENT OF SOCIAL RESPONSIBILITY IN PHARMACEUTICAL BUSINESS
Kareva N.N., Shvetsova V.D.
Abstract
The problem of social responsibility is becoming more and more important both for the state and the society. More and more companies are involved in social dialogue, in cooperation between business and society trying to create the image and reputation of a socially responsible company and to meet public expectations for their products or service. This study presents the analysis of social responsibility in large pharmacy chains of St. Petersburg. The obtained data allow to conclude that the conditions for development and scientific foundation of the methodology of social responsibility in the pharmacy business have appeared.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):32-37
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WAYS OF ENSURING AVAILABILITY OF DRUG ANALGETICS FOR PATIENTS WITH MALIGNANCIES
Lebedeva M.V., Kononova S.V., Gladunova E.P., Paigin F.R.
Abstract
The article analyzes the prevalence of cancer in Nizhny Novgorod region and the rationale for the need to improve the provision of patients with narcotic analgesics. The analysis of manufacturability, storage, and import into the Russian Federation of the required amount of pharmaceutical substances and drugs for providing adequate pain relief.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):38-43
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ANALYSIS OF A RANGE OF PRESCRIPTION MEDICINES BY THE EXAMPLE OF PHARMACEUTICAL ORGANIZATIONS OF THE SAMARA REGION
Okoryak Y.O., Petrukhina I.K.
Abstract
The article is devoted to the analysis of the consumption of prescription drugs in the pharmaceutical organizations of the Samara region. Using the example of the pharmacy network of Samara region the structure of consumption of Rx medicines was studied. The results of the study made it possible to determine the medicines having maximum sales volumes in physical and monetary matters; the predominant groups according to anatomical, therapeutic and chemical classification depending on the sales volumes.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):44-50
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FEATURES OF ORGAN PRESERVATION SURGICAL TREATMENT AND MORPHOLOGICAL STRUCTURE OF TUMORS AND OVARIAN TUMORS IN WOMEN OF REPRODUCTIVE AGE
Demura А.А., Spiridonova N.V.
Abstract
The article is devoted to the topical concepts of the nosological process in the ovaries of women of reproductive age. A prospective study of 168 patients of reproductive age (18-39 years) with tumors and ovarian tumors was conducted. The study included 101 patients (60.1%) with benign tumors, 24 patients (14.3%) with borderline tumors and 43 women (25.6%) with malignant tumors. Histological investigation revealed the following types of tumors: epithelial ones in 116 (69.05%), germ-cell tumours in 35 (20.8%), tumors of genital cord in 9 (5.36%), tumour-like masses in 8 patients (4.76%). Organ-preserving volume of surgical treatment was carried out in 89 cases (52.97%), in patients with borderline tumors in 16 cases (9.5%), in patients with malignant tumors in 8 cases (4.76%). After organ preservation treatment recurrent tumours within 3-5 years were revealed in 25% of patients with malignant tumors and 6.25% with borderline tumors.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):51-56
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РLACENTA AND FETAL MEMBRANES WITH PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY
Kaganova M.A., Spiridonova N.V., Larina T.V., Beskov D.S., Zotova Y.V., Syresina S.V., Mamedzade F.R.
Abstract
Background. The frequency of premature rupture of the membranes (PROM) ranges from 2.7 to 17%. The main problem of the PROM is the increased risk of septic complications for both the mother and the fetus. Histopathological tests of placenta proves to be important for the diagnosis of choriomnionitis and in the prognosis of newborn’s intrauterine infection. The aim of the research is to reveal the most significant histological changes in the placenta and fetal membranes with PROM in full-term pregnancy as compared to the placental complex of patients with intact fetal membrane and onset of labor. Materials and methods. Our study included 88 pregnant women at 37-42 weeks of pregnancy. According to the inclusion and exclusion criteria, patients were divided into two groups. Primary group included 58 patients with term pregnancy who were diagnosed PROM and underwent caesarean section within 6 hours. Control group included 30 patients without PROM and uterine contractions with elective caesarean section. Exclusion criteria for both groups were specific viral and/or bacterial infections during the pregnancy, severe extragenital maternal pathology and complications of gestation (hypertension, preeclampsia, gestational diabetes, fetal anomalies), the presence of any signs of infection within the last 48 hours. A standard morphological study of the placenta and membranes was performed, the sections were stained with hematoxylin-eosin. Results. Newborn outcomes did not significantly differ in both groups, the physiological course of adaptation was present in 44 (75.86%) children in the primary group and 24 (80%) in the control group. Morphological signs of the inflammatory process in the fetal membranes and placenta were found in both the primary and control groups. However, diffuse inflammatory process, especially in combination with phlebitis and funiculitis was observed three times frequently in patients with PROM. Conclusion. We did not find a significant correlation between the severity of inflammatory changes in the placenta and clinical sings of the intrauterine infection in groups with PROM and intact fetal membrane. Inflammatory changes in the placenta and fetal membranes were equally observed in both groups, but the lesions were more diffuse and difficult in the group with PROM.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):57-64
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THE EXPERIENCE OF REDUCING THE INDEX OF MULTIPLE PREGNANCIES IN THE IVF AND ICSI PROGRAMS
Saraeva N.V., Spiridonova N.V., Tugushev M.T., Shurygina O.V.
Abstract
The article presents the experience of the ART clinic in reducing the index of multiple pregnancy after the IVF, the IVF + ICSI programs. The decrease in the share of cycles with two embryos transfer on the 2 and 3 days of development and increasing in the share of cycles with one blastocyst transfer led to decrease of the multiple pregnancies rate in the clinic from 29% in 2006 to 6% in 2017. It is shown that one blastocyst transfer reduces the multiple pregnancy rate without a significant reduction in the overall clinical pregnancy rate. With reference to the performed analysis the algorithm of selecting of the day of embryo transfer and the number of embryos transferred embryos was developed.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):65-70
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EVALUATION OF STIFFNESS OF THE VESSELS IN THE NATURE OF HEARING LOSS IN OLDER ADULTS WITH HYPERTENSION
Vladimirova T.Y., Aizenshtadt L.V.
Abstract
Hearing loss in patients of the older age group is a common problem which contributes to both age-related changes and cardiovascular disorders in the history. The aim of the work was to assess the stiffness of the vascular wall in elderly patients with arterial hypertension in the presence and absence of complaints of hearing. The study involved 40 patients who in addition to the hearing study were measured the stiffness of the vascular wall on the VaSera VS-1000 device (Fukuda Denshi, Japan). The results show that the absence of complaints of hearing loss does not exclude the possibility of hearing disorders. In 75% of cases the correlation between vascular stiffness and the intensity of auditory disorders was revealed.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):71-75
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PARAMETERS OF THE MYOCARDIAL DEFORMATION OF THE LEFT VENTRICLE IN PATIENTS WITH CHRONIC HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION
Vdovenko D.V., Libis R.A.
Abstract
Aim. The aim of the research is to study the myocardial function in patients with chronic heart failure with preserved left ventricular ejection fraction (CHF-PEF) by means of speckle tracking echocardiography. Matherials and methods. We examined 76 patients aged from 50 to 69 years with verified CHF-PEF with NYHA (New York Heart Association) class I-IIa and stage A-C of the ABCD classification of the American College of Cardiology, and 30 healthy persons. In the studied patients CHF-PEF developed due to arterial hypertension and coronary artery disease. We carried on 6-minute walk test to evaluate the functional class of CHF-PEF, echocardiography and speckle-tracking echocardiography to examine left ventricle systolic and diastolic function and parameters of the myocardial deformation. Results. According to the 6-minute walk test the patients were divided as followed: 26.6% - stage A, 48.3% - stage B, 25.1% - stage C. The average left ventricular ejection fraction measured by Simpson’s method was 62.5 ± 4.36%. All patients with CHF-PEF had the diastolic dysfunction: abnormal relaxation pattern was found in 58 patients, and 18 persons demonstrated pseudonormal pattern. We revealed that patients with CHF-PEF had reduced global longitudinal strain (GLS -16.56 ± 2.75%) and GLS rate (GLSR -0.77 ± 0.16 s-1) of the left ventricle and reduced segmental strain and strain rate in basal anteroseptal (-13.8 ± 2.79% and -0.76 ± 0.03 s-1) and basal anterolateral (-14.55 ± 3.68% and -0.81 ± 0.11 s-1) segments. In comparison with the global longitudinal strain we found the lower value of the circular strain and strain rate reduction (-15.63 ± 4.8% and -1.4 ± 0.22с s-1), (p < 0.05). Changes of the radial strain and strain rate were not revealed. Positive correlation between systolic longitudinal strain and left atrium volume (r = 0.602, р < 0.01) was found. Conclusions. Patients with CHF-PEF have abnormal relaxation pattern and pseudonormal pattern of the diastolic dysfunction. They also have reduced global and segmental strain and strain rate of the left ventricle. Circular strain was slightly reduced and radial strain was unchanged.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):76-84
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EXTRASYSTOLIC ARRHYTHMIA: HEMODYNAMIC ASPECTS AND BIOMECHANICS OF MAIN ARTERIES
Germanova O.A., Germanov A.V., Germanov V.A., Piskunov M.V., Borzenkova G.A., Kolesnikov I.S.
Abstract
Nowadays the peculiarities of the changes of the parameters of heart biomechanics and kinetics of the main arteries in case of extrasystole has not been studied well. The changes of these parameters may cause different complications. The existing classifications of extrasystole are based on the localization of the ectopic center, but there is no classification of types of extrasystole which takes into consideration the time of their appearance in cardiac cycle. In this article, hemodynamics and biomechanics of the main arteries in different types of extrasystole are described. The changes of main parameters like speed, acceleration, power, work are evaluated. The main adverse effects of extrasystole are determined in the article. We offer the functional classification of extrasystole in relation to the moment of its appearance in cardiac cycle. We also validate the clinical applicability of this classification.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):85-92
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NON-CARdIOGENIC THROMOEMBOLIC COMPLICATIONS IN ATRIAL FIBRILLATION
Germanov A.V., Germanova O.A., Tereshina O.V., Germanov V.A., Piskunov M.V., Stepanov M.Y.
Abstract
Intracardiac thrombus of the left atrial appendage or left ventricular apex are considered to be the causes of thromboembolic complications in atrial fibrillation. However, in many cases it is difficult to reveal the source of embolism despite thorough examination of the patient. In this article, we analyze other potential sources of thromboembolic complications in atrial fibrillation. Changes in the main parameters of heart biomechanics and main arteries hemodynamics (speed, acceleration, power, work) in case of permanent atrial fibrillation are described. The most dangerous type of atrial fibrillation from the perspective of the development of thromboembolic complications was determined. The article describes the mechanisms of the development of thromboembolic complications in patients without left appendage thrombus and thrombosis of heart apex. The need to perform 24-hours ECG monitoring and sphygmography of main arteries in order to evaluate the risk of thromboembolic complications is justified in the article.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):93-99
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SELECTION OF DABIGATRAN DOSAGE AFTER RADIOFREQUENCY ABLATION IN PATIENTS WITH PAROXYSMAL ATRIAL FIBRILLATION IN DEPENDENCE TO THE RISK OF RECURRENCE ACCORDING TO PRE-OPERATIVE EXAMINATION
Korneluk O.M., Mrochek A.G., Goncharik D.B., Chacnoits A.R., Barsukevich V.C., Kovsh E.V., Kornelyuk I.V.
Abstract
The study included 36 patients (25 men and 11 women) with a paroxysmal atrial fibrillation (AF), who were performed radiofrequency ablation of pulmonary vein (RFA PV). Depending on the presence or absence of recurrence within 3 to 6 months after RFA all patients were divided into 2 groups. 22 people (61%) received warfarin, dabigatran was received by 14 people (39%) as an anticoagulant. Dabigatran in a daily dosage of 220 mg and 300 mg provided a comparable clinical effect preventing thromboembolic complications in patients after RFA PV. Preoperative examination shows that patients with a low risk of recurrence within 6 months after the RFA PV may be recommended dabigatran at a daily dose of 220 mg.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):100-106
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СHROMOGRANIN A AS A POTENTIAL MARKER OF A CARDIOVASCULAR RISK IN PATIENTS WITH ESSENTIAL HYPERTENSION (LITERATURE REVIEW)
Gubareva E.Y., Kryukov N.N., Gubareva I.V., Zheltyakova O.V., Martynenko I.D.
Abstract
Recent clinical studies demonstrate the possibility of glycoprotein chromogranin A (CgA) use not only for the diagnosis of neuroendocrine tumors and secondary hypertension, but also as the essential hypertension (EH) and associated states cardiovascular risk marker. However, the evidence base is small and contradictory. The article presents a review of key studies on the topic, arguing the use of CgA in patients with EH.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):107-112
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THE DYNAMICS OF THE MORBIDITY RATE OF CHILDREN WHO UNDERWENT REHABILITATION IN A SPECIALIZED CENTER OF REHABILITATION TREATMENT IN SAMARA IN 2016-2017
Napalkovа S.A., Mazur L.I., Zhirnov V.A.
Abstract
The article evaluates the effectiveness of the centers of restorative treatment as exemplified by the children’s department of the rehabilitation treatment of SBHCI SR “SMOC No. 3”. The state of children’s health assessment included the analysis of the disease incidence within 2016-2017. Deterioration of visual function increased by 6.5% in 2017 while the number of children with respiratory system disorders decreased by 5.8%. Positive dynamics was registered in 94.9% of children.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):113-116
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RESULTS OF RADIOFREQUENCY THERMOABLATION AND REPEATED LIVER RESECTION IN PATIENTS WITH METASTASES OF COLORECTAL CANCER AFTER PRIMARY LIVER RESECTIONS. COMPARATIVE ANALYSIS
Vishnevskiy V.A., Ionkin D.A., Gavrilov Y.Y., Zhavoronkova O.I.
Abstract
The aim of the study is to evaluate patients’ treatment outcome with recurrent CRC liver metastases after previous resection taking into account the use of RFA. Materials and methods. Retrospective analysis of treatment outcome of 29 patients with recurrent colorectal liver metastases after previous liver resection over the period of 2005-2015 was performed. The group of patients who underwent repeated resection included 17 patients, as compared with 12 patients who underwent RFA after previously performed liver resection. Results. Postoperative complications in the group with RFA occurred in 30% of patients, 88% in the group with repeated resection and case fatality rate was 5.9%. Radical treatment was performed in 58.8% of patients. In case of recurrent radical surgery the 5-year survival rate was 50% with median survival 31.4 months. RFA in patients with previous liver resection for metastases due to CRE resulted in 5-year survival rate in 33.3% of all cases and median survival was 24.5 months. No 5-year survival rate was revealed in non-radical recurrent resection. Summary. The analysis of patient outcomes (2005-2015) with recurrence of colorectal cancer metastases to the liver after previous liver resection and RFA. Immediate results and follow-up outcomes of both methods are described in the article. The analysis of the further treatment of the patients of these groups is performed. Conclusion. RFA in patients with previous resection for CRC liver metastases is a promising means of treatment for this group of patients. RFA can be considered as an independent method of treatment and to a certain degree it can be alternative for recurrent resection. It can also be an auxiliary step in the treatment prior to repeated resection in order to stabilize somatically preoccupied patients.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):117-126
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THERMAL METHODS OF LOCAL DESTRUCTION (RFA, CRYODESTRUCTION, MICROWAVE ABLATION) IN METASTATIC LIVER CANCER
Ionkin D.A., Zhavoronkova O.I., Stepanova Y.A., Gavrilov Y.Y., Chzhao A.V., Vishnevsky V.A.
Abstract
The article studies the technique of local destruction of colorectal liver metastases. 298 sessions of radiofrequency ablation (RFA) were performed in 182 patients. 20 patients underwent cryodestruction. 18 patients underwent percutamenous microwave ablation (MVA) and in 4 cases it was combined with hepatic resection. Applicability of various combinations of local thermal destruction methods is studied in the article. After the RFA, 45 (15.1%) cases of complications and 2 lethal outcomes were noted in the postoperative period. Severe life-threatening complications were revealed in 12 (4.02%) patients. Repeated RFA sessions were complicated more often: in 11.1% of cases as compared to primary 5.1% of observations (р < 0.01). Complications caused by bile duct trauma in particular were much more frequent in cases when foci were localized in central liver segments and in the left lobe (р < 0.01). Complications after cryodestruction were noted in 8 (40%) patients including 2 (10%) cases of severe complications. There were no lethal outcomes of cryodestruction. Indications and contraindications to the use of local destruction in colorectal liver metastases were determined. Characteristics of postoperative management of patients after thermal destruction have been revealed. RFA for colorectal liver metastases resulted in 1-, 2-, 3-, 4- and 5-year survival rates in 84.2; 56.7; 39.7; 28.4 and 23.4% respectively. Median survival is 30 months. Cryodestruction for CRC liver metastases resulted in 1, 2, 3 and 5-year survival rates in 72.2; 62.2; 25.2 and 6.4% respectively. Median survival is 28 months. Incomplete destruction of neoplasms near the main vessels was revealed in 4 (22.2%) cases after MBA. In the postoperative period subcapsular biloma was found in 1 (5.5%) case. Right-sided hydrothorax was noted in 4 (22.2%) cases, in 1 (5.5%) case it required pleural puncture. The use of MBA and various combinations of methods of local destruction requires further study. All patients after the interventions with the use of thermal destruction underwent adjuvant chemotherapy, and in 18 cases chemoembolization was performed. Thermal methods of local destruction should be considered as a reasonable alternative to existing surgical methods and in some cases as a component of combined treatment of hepatic cancer metastatic. Treatment outcomes in patients with hepatic cancer treated by means of various methods of destruction, as well as their combination and in case of liver resection depend on the factors of prognosis like time of detection, localization, size, number and type of a tumor.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):127-145
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NON-INVASIVE TECHNIQUES FOR DIAGNOSTICS OF SKIN NEOPLASMS
Kozlov S.V., Zaharov V.P., Morjatov A.А., Kaganov O.I., Bratchenko I.A., Artemyev A.D.
Abstract
The article presents the data on epidemiology and diagnostic techniques of cutaneous melanoma. New method of skin neoplasms diagnosics is suggested. Objective of the research is to develop a new method of early non-invasive differential diagnostics of skin neoplasms. The results of resonance Raman spectroscopy of human skin neoplasms in vitro and in vivo are analyzed. The article demonstrates that this method of original two-stage phase analysis of obtained parameters possesses high sensitivity and specificity scores. Conclusions: new technique of early non-invasive skin neoplasms diagnosis is suggested.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):146-151
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ANALYSIS OF THE FUNCTIONAL INDICATORS OF THE STATE OF PARODONT IN PATIENTS WITH CHRONIC GENERALIZED PARODONTITIS IN THE TIME PROFILE OF LASEROTHERAPY
Lubomirsky G.B.
Abstract
Periodontal diseases each year preserve the state of the commonest forms of dental pathology. The study was aimed at investigating the functional parameters of periodontal tissues in case of chronic generalized periodontitis when the conventional treatment was combined with laser treatment. 300 people with chronic generalized periodontitis of medium severity were examined. The investigation of functional indicators of periodontal tissues state while laser therapy revealed significan health benefit for periodontal tissues state.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):152-161
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Dynamics of surgical care of elderly patients who undergo prolonged anticoagulant treatment with new oral anticoagulants at the private dental office over the period of 5 years (2013-2017)
Parfenyuk G.V.
Abstract
The article studies epidemiological situation over the period of five years, in respect of patients who had prolonged anticoagulant therapy with new oral anticoagulants and approached to private dental office for the tooth extraction surgery(s). The main indicators of dynamic series analysis were used to establish the trends of the studied phenomenon. The findings of the investigation confirmed the annual increase in the number of outpatients who underwent prolonged anticoagulant therapy with new oral anticoagulants at the office of dental surgeon.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):162-166
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GRAVITATIONAL THERAPY AS THE POTENTIAL METHOD OF THE REHABILITATION OF ATHLETES
Akulov V.A., Makarov I.V., Kositsina G.V.
Abstract
Basing on World Cup 2018 we proposed to use gravitational therapy to facilitate rehabilitation of athletes and football players in particular. The article presents interdisciplinary analysis (technology and medicine) of the quality of the football pitch, and it is viewed as a time- and space-limited environment of the most qualified athletes which contributes to high risk of traumatism. Due to the tight schedule of the World Cup tournament it’s important to minimize the rehabilitation period for football players. Gravitational therapy proved to be an efficient in the treatment of the patients with traumas, orthopaedic disorders, limb ischaemia. Due to the lack of official trauma statistics during World Cup tournament, it is estimated by means of indirect methods.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):167-174
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LAPAROSCOPIC OCCLUSION LEFT TESTICULAR VEIN IN THE TREATMENT OF VARICOCELE (FIRST CLINICAL EXPERIENCE)
Joldoshbekov E.Z., Osmonaliev B.K., Avasov B.A.
Abstract
The aim of the article is to presents first clinical experience of laparoscopic occlusion of testicular veins in the treatment of varicocele. Materials and methods. Operations were performed in 4 patients aged 18-27 years. Depending on the degree of the disease, patients were distributed as follows: 1 patient with I degree, 3 patients with II degree. The laparoscopic occlusion of the left testicular vein was performed by using an endoscopic stand “ALLGAIR” (Belgium-Germany). The operation was performed under intravenous anesthesia with tracheal intubation. The patient was on his back in a modified Trendelenburg position with his left side raised by 15°. In the umbilical region insufflation of carbon dioxide was performed by means of a Veress needle. Endoscopic panoramic exporation of the abdominal cavity and the topography of testicular vein were performed after the introduction of the laparoscope. The results of the study. There were no complications and mortality in the early postoperative period. Control postoperative examinations of patients were carried out in 1, 3, 6 months, no recurrence was revealed during this period. Conclusion. Insufficient clinical data prervent from drawing definite conclusion. However the given method has a number of advantages: it is minimally invasive, it has painless postoperative period, it reduces the duration of hospital stay up to 1 day, it also results in rapid restoration of normal physical activity. Further accumulation of clinical material is needed to reach certain conclusions and recommendations.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):175-178
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EVALUATION OF THE EFFECTIVENESS OF RADIATION AND COMBINED TREATMENT OF PATIENTS WITH RECURRENCE OF ESOPHAGEAL CANCER IN THE CERVICAL LYMPH NODES
Makarov I.V., Satybaldiyev T.D., Sidorov A.Y., Dolzhenko K.I.
Abstract
The aim of the article is to present improvement of immediate and remote treatment outcomes of patients with metastases in cervical and supraclavicular lymph nodes after surgical treatment of esophageal cancer. Materials and methods. Metastases in cervical and supraclavicular lymph nodes after surgical treatment of esophageal cancer are found in 7-12% of cases. Following classical cervical lymph nodes tele-irradiation 25 patients underwent cervical lymph node dissection. Crile’s operation or radical neck dissection is the standard operation for removal of malignant cervical lymph nodes. Results. Special attention should be paid to the life expectancy of 25 patients who underwent the combined therapy for esophageal cancer recurrence in cervical lymph nodes: 10 people (40.0 ± 9.8%) have survived two-year limit and 5 patients (20.0 ± 8.6%) lived for three years. Conclusion. The presence of cervical lymph nodes metastases in patients with esophageal cancer is not always the sign of a patient’s hopeless condition. Early detection of recurrent tumors and their combined treatment allow to achieve a significant improvement of long-term results.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):179-182
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REPARATIVE LIVER REGENERATION AFTER SEGMENTAL RESECTION (literature review)
Andreev A.A., Ostroushko A.P., Laptiyova A.Y., Glukhov A.A.
Abstract
Post-resection liver regeneration with restoration of its functions is one of the criteria for the effectiveness of surgical treatment in traumatic, toxic, infectious and metastatic lesions of the organ. The article is devoted to the study of modern concepts of reparative regeneration of the liver after extensive resection with removal of three or more segments. Much attention is paid to the mechanisms of organ restoration at different volume of resection and phases of proliferative process. Inductors of hepatocyte regeneration and their influence on the phases of the cell cycle are described. But it’s important to emphasize that the problem of post-resection reparative regeneration of the liver remains topical as the frequency of postoperative complications in resections averages 38%.
Aspirantskiy Vestnik Povolzhiya. 2018;18(5-6):183-190
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