Severe pseudomembranosic colitis with encephalopathy and edemate syndrome


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Abstract

During the pandemic, the number of cases of pseudomembranous colitis in patients infected with SARS-CoV-2 increased significantly. The article presents a clinical case of pseudomembranous colitis in a 68-year-old female patient during hospitalization for COVID-19. The peculiarity of this case is the dominance of encephalopathy manifestations in common clinical picture, in connection with which the patient was urgently hospitalized in the neurological department with acute cerebrovascular accident referral diagnosis. The development of severe encephalopathy in patients with pseudomembranous colitis is taking place due to a direct toxic effect at the central nervous system of enterotoxin TcdB Clostridium difficile. Pleural effusion and ascites were other main clinical manifestations of pseudomembranous colitis in current clinical observation.

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About the authors

Khadizhat A. Khamidova

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: k.khamidova@mail.ru
PhD in Medicine, associate professor of the Department of hospital therapy No.1

Lyudmila A. Panchenkova

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: lapanchenkova@mail.ru
Dr. med. habil., professor, professor

Natalia A. Bulanova

G.R. Derzhavin Tambov State University; CH «RZD-Medicine» named after N.A. Semashko; Central State Medical Academy of the Administration of the President of the Russian Federation

Email: bulanovanatalia@mtu-net.ru
Dr. med. habil., associate professor, professor of the Department of hospital therapy

Galina G. Karnuta

CH «RZD-Medicine» named after N.A. Semashko

PhD in Medicine, head of the Department of gastroenterology

Svetlana Yu. Zinovieva

CH «RZD-Medicine» named after N.A. Semashko

doctor at the Department of gastroenterology

Tatyana D. Khomyakova

CH «RZD-Medicine» named after N.A. Semashko

chief physician

Vladimir V. Popov

G.R. Derzhavin Tambov State University; CH «RZD-Medicine» named after N.A. Semashko; Medical Institute of continuing education of Moscow State University of Food Production

Dr. med. habil., professor of the Department of pharmacology and biochemistry; professor of the Department of therapy with a course of pharmacy

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