Predicting the risk of development of cerebral stroke in patients in the remote period after myocardial revascularization taking into account renal risk factors


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Formation and improvement of systems of stratification of cardiovascular risk is a priority of preventive medicine, especially for the most socially significant diseases - stroke and coronary heart disease. The study established a new marker of stroke in patients with chronic myocardial ischemia in the long term after coronary revascularization - β2-microglobulin. It is demonstrated that in the presence of β2-microglobulinuria other renal risk factors (albuminuria 30-300 mg/l, the decrease in GFR) and the presence of postinfarction cardiosclerosis have a potentiating effect on the risk of development of stroke. The findings suggest common mechanisms of progression of renal and cardiovascular pathologies.

Full Text

Restricted Access

About the authors

Yekaterina Sergeevna Levitskaya

Rostov State Medical University

Email: es.med@mail.ru
PhD, assistant of the Department of internal diseases № 2

Mikhail Mikhailovich Batyushin

Rostov State Medical University

Email: batjushin-m@rambler.ru
MD, professor, professor of the Department of internal diseases № 2

References

  1. Всемирная организация здравоохранения. Информационный бюллетень. Сердечно-сосудистые заболевания. 2016. http://www.who.int/cardiovascular_diseases/about_cvd/ru/ [World Health Organization. Newsletter. Cardiovascular disease. 2016 (in Russian)]
  2. Roquer J., Segura T., Serena J., Castillo J. Endothelial dysfunction, vascular disease and stroke: the ARTICO study. Cerebrovasc. Dis. 2009;27(1):25-37.
  3. Astor B.C., Muth B., Kaufman D.B., Pirsch J.D., Hofmann M.R., Djamali A. Serum ß2-microglobulin at discharge predicts mortality and graft loss following kidney transplantation. Kidney Int. 2013;84:810-7.
  4. Yilmaz B., Köklü S., Yüksel O., Arslan S. Serum ß2-microglobulin as a biomarker in inflammatory bowel disease. World J. Gastroenterol. 2014;20(31):10916-20.
  5. Ronco C. Cardiorenal syndrome: refining the definition of a complex symbiosis gone wrong. Intensive Care Med. 2008;34:957-62.
  6. Hofstra J.M., Willems J.L., Wetzels J.F.M. Nephrol. Dial. Transplant. 2011;26(2):550-56.
  7. Батюшин М.М., Левицкая Е.С., Терентьев В.П., Сависько А.А., Дюжиков А.А., Куликовских Я.В. Почечные и коронарные предикторы прогноза у больных ишемической болезнью сердца, перенесших реваскуляризацию миокарда. Российский кардиологический журнал. 2012;6(98):45-50. [Batyushin M.M., Levitskaya Ye.S., Terentiev P.V., Savisko A.A., Dyuzhikov A.A., Kulikovskikh Ya.V. Renal and coronary predictors of prognosis in patients with ischemic heart disease undergoing myocardial revascularization. Russian journal of cardiology. 2012;6(98):45-50 (in Russian)]
  8. Vianello A., Caponi L., Galetta F., Franzoni F., Taddei M., Rossi M., Pietrini P., Santoro G. ß2-microglobulin and TIMP1 are linked together in cardiorenal remodeling and failure. Cardiorenal. Med. 2015;5(1):1-11.
  9. Левицкая Е.С. Батюшин М.М., Терентьев В.П., Дюжиков А.А., Хрипун А.В. Оценка влияние почечных факторов риска и параметров коронарной атеросклеротической бляшки на вероятность развития рецидива стенокардии у больных, подвергшихся реваскуляризации миокарда. Клиническая нефрология. 2012;3:30-3. [Levitskaya Ye.S., Batyushin M.M., Terentiev V.P., Dyuzhikov A.A., Khripun A.V. Assessing the impact of renal risk factors and parameters of coronary atherosclerotic plaques on the probability of development of recurrent angina in patients undergoing myocardial revascularization. Clinical Nephrology. 2012;3:30-3 (in Russian)]
  10. Yuyun M.F., Khaw K.T., Luben R., Welch A., Bingham S., Day N.E., Wareham N.J. Prospective study of microalbuminuria and incident coronary heart disease and its prognostic significance in a british population The EPIC-Norfolk Study. Am. J. Epidemiol. 2004;159(3):284-93.
  11. DeFilippis A.P., Kramer H.J., Katz R., Bertoni A.G., Jeffrey C., Budoff M.J., Blumenthal R.S., Nasir K. Association between coronary artery calcification progression and microalbuminuria. J. Am. Coll. Cardiol. Img. 2010;3:595-604.
  12. Sander D., Weimar C., Bramlage P., Brandt T., Rosin L., Siebler M. Microalbuminuria indicates long-term vascular risk in patients after acute stroke undergoing in-patient rehabilitation. BMC Neurol. 2012;12:102.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies