Pharmacoepidemiological study of ethnic differences in the use of antihypertensive drugs for hospital treatment of residents of the Karachay-Cherkess Republic


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Abstract

Pharmacoepidemiological evaluation of the use of antihypertensive drugs in 300 hypertensive patients who were treated in the cardiological hospital was performed. Patients were divided into three ethnic groups: the Slavs (the Russians and the Ukrainians) (45 men and 55 women), the Karachays (51 men and 49 women), and the Circassians (43 men and 57 women). Angiotensin-converting enzyme (ACE) inhibitors, diuretics and beta-adrenoblockers (BAB) were equally often prescribed to patients of all ethnic groups. The assessment of the combined use of antihypertensive drugs revealed that the combination of ACE inhibitors, diuretics and blockers was most commonly prescribed to the Circassians. The combination of ACE inhibitors and diuretics was often administered in the Slavic group and less often in Karachay ethnic group. Karachays often received BAB in combination with diuretics, and the Slavs and the Circassians -more rarely. The evaluation of the blood pressure at hospital discharge showed that the representatives of the Circassian ethnic group rarely achieved the desired effect of antihypertensive drugs despite more intensive pharmacotherapy.

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About the authors

Vladimir Aleksandrovich Baturin

Stavropol state medical university

MD, professor, head of the Department of clinical pharmacology

Angela Ismailovna Elkanova

Stavropol state medical university

Email: elkanova@gmail.com
applicant of the Department of clinical pharmacology

References

  1. Федеральное руководство по использованию лекарственных средств (формулярная система). Выпуск XV. М.: Эхо, 2013. 1020 с. [Federal guidance on the use of drugs (formulary system). Issue XV. Moscow: Echo, 2013. 1020 p. (in Russian)]
  2. Прикладная фармакоэпидемиология. Под ред. В.И. Петрова. М.: ГЭОТАР-Медиа, 2008. 384 с. [Applied pharmacoepidemiology. Edited by V.l. Petrov. M.: GEOTAR-Media, 2008. 384 p. (in Russian)]
  3. Батурин В.А., Колодийчук Е.В. Половая диссимиляция эффектов кардиотропных средств. Ставрополь, 2003. 111 с. [Baturin V.A., Kolodiychuk Ye.V. Sexual dissimilation of effects of cardiotropic drugs. Stavropol, 2003. 11 1 p. (in Russian)]
  4. Батурин B.A., Яковлева H.В. Особенности антигипертензивного действия ингибиторов АПФ у русских и армян при артериальной гипертонии. Биомедицина. 2006;3:119-20. [Baturin V.A., Yakovleva N.V. Characteristics of antihypertensive action of ACE inhibitors in Russians and Armenians with arterial hypertension. Biomedicine. 2006;3:119-20 (in Russian)]
  5. Терентьева И.В. Сложившаяся практика потребления кардиотропных средств при лечении мужчин и женщин, больных ИБС, в стационаре. Медицинский вестник Северного Кавказа. 2009;4:45-9. [Terent'eva I.V. Current practice of consumption of cardiotropic agents in the treatment of men and women with coronary heart disease in hospital. Medical bulletin of the North Caucasus. 2009;4:45-9 (in Russian)]
  6. Кукес В.Г., Грачев C.B., Сычев Д.А., Раменская Г.В. Метаболизм лекарственных средств. Научные основы персонализированной медицины: руководство для врачей. М.: ГЭОТАР-Медиа, 2008. 308 с. [Kukes V.G., Grachev S.V., Sychev D.A., Ramenskaya G.V. Metabolism of drugs. The scientific basis of personalized medicine: a guide for physicians. Moscow: GEOTAR-Media, 2008. 308 p. (in Russian)]
  7. Сычев Д.А., Муслимова O.B., Гаврисюк E.В., Косовская A.B., Кукес В.Г. Фармакогенетические технологии персонализированной медицины: оптимизация применения лекарственных средств. Terra Medica. 2011 ; 1:4-9. [Sychev D.A., Muslimova O.V., Gavrilyuk Ye.V., Kosovskaya A.V., Kukes V.G. Pharmacogenetic technologies in personalized medicine: optimizing the use of medicines. Terra Medica. 2011 ; 1:4-9 (in Russian)]
  8. Батурин B.A., Яковлева H.В., Царукян A.A. Вариативность фармакологического эффекта, обусловленная этнической принадлежностью. Психофармакология и биологическая наркология. 2007;7:1603. [Baturin V.A., Yakovleva N.V., Tsarukyan A.A. Variability of the pharmacological effect due to ethnicity. Psychopharmacology and biological narcology. 2007;7:1603 (in Russian)]
  9. Теучеж И.Э., Почешхова Э.А., Схаляхо P.A., Дибирова Х.Д., Агджоян A.T., Утевская О.М., Кузнецова М.А., Богунов Ю.В., Шанько A.B., Коньков А.С., Чиковани H.H., Епископосян Л.М., Балановская Е.В., Балановский О.П. Генофонды абхазо-адыгских народов, грузин и армян в евразийском контексте. Вестник Московского университета. Серия XXIII. Антропология. 2013;2:49-62. [Teuchezh I.E., Pocheshkova Е.А. Skhalyakho R.A., Dibirova Kh.D., Agjoyan A.T., Utevska O.M., Kuznetsova M.A., Bogunov Yu.V., Shan'ko A.V., Kon'kov A.S., Chikovani N.N., Yepikoposyan L.M., Balanovsky Ye.V., Balanovsky O.P. Gene pools of the Abkhaz-Adyghe peoples, Georgians and Armenians in the Eurasian context. The Moscow University Herald. Series XXIII. Anthropology. 2013;2:49-62 (in Russian)]

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