SYSTEMIC SCLERODERMA AND CHRONIC KIDNEY DISEASE


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Abstract

The article considers the variants of chronic kidney disease (CKD) in systemic scleroderma (SSD). Following manifestations of subclinical CKD in this disease should be noted: 1) an isolated decrease in glomerular filtration rate; 2) an increase in the renal resistivity index; 3) decreased renal functional reserve. 15-year survival rate in SSD patients without CKD is 72%, in the presence of CKD - not more than 13%. The importance of the phenomenon of vascular endothelial dysfunction in the pathogenesis of CKD in SSD is discussed in detail. It is emphasized that a variety of drugs used in this disease, in the first place, D-penicillamine, can contribute to the development of CKD in the SSD.

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About the authors

Anastasiya Yu. ZAKHAROVA

junior researcher, V.A. Nasonova Research Institute of Rheumatology. 115522, Moscow, 34a Kashyrskoe shosse

Andrey V. GORDEEV

Email: andrewgordeew@gmail.com
MD, professor, senior researcher, V.A. Nasonova Research Institute of Rheumatology. 115522, Moscow, 34a Kashyrskoe shosse

Zinaida Yu. MUTOVINA

PhD, associate professor of Department of therapy, cardiology and functional diagnostics with a course of nephrology and rheumatology, Educational scientific medical center 121359, Moscow, 19, bld. 1A Marshala Timoshenko St

Lidiya P. ANANYEVA

Email: lpana@yandex.ru
MD, professor, head of Laboratory of microcirculation and inflammation, V.A. Nasonova Research Institute of Rheumatology. 115522, Moscow, 34a Kashyrskoe shosse

Yelena A. GALUSHKO

MD, head of Educational-methodical department with the information technology center, V.A. Nasonova Research Institute of Rheumatology. 115522, Moscow, 34a Kashyrskoe shosse

References

  1. Гусева Н.Г. Системная склеродермия. М.: Медицина, 1975. 270 с. [Guseva N.G. Systemic sclerodermia. Moscow: Medicine, 1975. 270 p. (in Russ.)]
  2. Lynch B., Burns A. Rheumatological conditions and the kidney. Practical Nephrology, ed. Harber M. Springer, 2014. Р. 291-5.
  3. Steen V.D., Medsger T.A. Change in causes of death in systemic sclerosis, 1972-2002. Ann. Rheum. Dis. 2007;66:940-4.
  4. Trostle D.C., Bedetti C.D., Steen V.D., Al-Sabbagh M.R., Zee B., Medsger T.A. Jr. Renal vascular histology and morphometry in systemic sclerosis. A case-control autopsy study. Arhritis Rheum. 1988;31(3):393-400.
  5. Shanmugam V.K., Steen V.D. Renal manifestations in scleroderma: evidence for subclinical renal disease as a marker of vasculopathy. Int. J. Rheumatol. 2010;2010. pii: 538589.
  6. Gigante A., Rosato E., Massa R., Rossi C., Barbano B., Cianci R., Molinaro I., Amoroso A., Salsano F. Evalution of Chronic Kidney Disease Epidemiology Collaboration equation to estimate glomerular filtration rate in scleroderma patients. Rheumatology. 2010;51:1426-31.
  7. Campo A., Mathai S.C., Le Pavec J., Zaiman A.L., Hummers L.K., Boyce D., Housten T., Champion H.C., Lechtzin N., Wigley F.M., Girgis R.E., Hassoun P.M. Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension. Am. J. Respir. Crit. Care. Med. 2010;182:252-60.
  8. Nishijima C., Sato S., Hasegawa M., Nagaoka T., Hirata A., Komatsu K., Takehara K. Renal vascular damage in Japanese patients with systemic sclerosis. Rheumatology. 2001;40:406-9.
  9. Rosato E., Gigante A., Barbano B., Cianci R., Molinaro I., Rossi C., Massa R., Amoroso A., Pisarri S., Salsano F. Intrarenal haemodynamic parametrs correlate with glomerular filtration rate and digital microvascular damage in patients with systemic sclerosis. Semin. Arthritis Rheum. 2012;41:815-21.
  10. Rosato E., Cianci R., Barbano B., Menghi G., Gigante A., Rossi C., Zardi E.M., Amoroso A., Pisarri S., Salsano F. N-acetylcycteine infusion reduces the resistance index of renal artery in the early stage of systemic sclerosis. Acta Pharmacol. Sin. 2009;30:1283-8.
  11. Livi R., Giuducci S., Perfetto F., Ciuti G., Grifoni E., Conforti L., Galluccio F., Moggi Pignone A., Matucci Cerinic M. Lack of activation of renal functional reserve predicts the risk of significant renal involvement in systemic sclerosis. Ann. Rheim. Dis. 2011;70:1963-7.
  12. Siva B.M, cDonald S.P., Hawley C.M., Rosman J.B., Brown F.G., Wiggins K.J., Bannister K.M., Campbell S.B., Johnson D.W. Endstage kidney disease due to scleroderma- outcomes in 127 consecutive ANZDATA registry cases. Nephrol. Dial. Transplant. 2011;26:3165-71.
  13. Meier F.M.P., Frommer K.W., Dinser R., Walker U.A., Czirjak L., Denton C.P., Allanore Y., Distler O., Riemekasten G., Valentini G., Müller-Ladner U.; EUSTAR Co-authors. Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database. Ann. Rheum. Dis. 2012;71:1355-60.
  14. Tyndall A.J., Bannert B., Vonk М., Airo P., Cozzi F., Carreira P.E., Bancel D.F., Allanore Y., Müller-Ladner U., Distler O., lannone F., Pellerito R., Pileckyte M., Miniati I., Ananieva L., Gurman A.B., Damjanov N., Mueller A., Valentini G., Riemekasten G., Tikly M., Hummers L., Henriques M.J., Caramaschi P., Scheja A., Rozman B., Ton E., Kumanovics G., Coleiro B., Feierl E., Szucs G., Von Mühlen C.A., Riccieri V., Novak S., Chizzolini C., Kotulska A., Denton C., Coelho P.C., Kötter I., Simsek I., de la Pena Lefebvre P.G., Hachulla E., Seibold J.R., Rednic S., Stork J., Morovic-Vergles J., Walker U.A. Cases and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann. Rheum. Dis. 2010;69:1809-1 5.
  15. Sieberlich L., Hunzelmann N., Krieg T., Weber M., Schulze-Lohoff E. Intermediate molecular weight proteinuria and albuminuria identify scleroderma patients with increased morbidity. Clin. Nephrology. 2008;70(2):110-7.
  16. Balakumar P., Chakkarwar V.A., Krishan P., Singh M. Vascular endothelial dysfunction: a tug of war in diabetic nephropathy? Biomed. Pharmacother. 2009;63:171-9.
  17. Shah R. Endothelin in health and disease. Eur. J. Intern. Med. 2007;18:272-82.
  18. Dhaun N., Goddard J., Webb D.J. The endothelin system and its antagonism in chronic kidney disease. J. Am. Soc. Nephrol. 2006;17(4):943-55.
  19. Anders H.J., Vielhauer V. Renal co-morbidity in patients with rheumatic disease Arthritis Res. Ther. 2011;13(3):222.
  20. Steen V.D., Costantino J.P., Shapiro A.P., Medsger T.A. Jr. Outcome of renal crisis in system sclerosis: relation to availability of angiotensin converting enzyme (ACE) inhibitors. Ann. Intern. Med. 1990;113:352-67.
  21. Derk C.T., Jimenez S.A. Goodpasture-like syndrome induced by D-penicillamine in patient with systemic sclerosis: report and review of literature. J. Rheum. 2003;30(7):1616-20.
  22. Гусева Н.Г. Системная склеродермия и псевдосклеродермические синдромы. М.: Медицина, 1993. [Guseva N.G. Systemic scleroderma and pseudoscleroderma syndromes. Moscow: Medicine, 1993 (in Russ.)]

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