VALUE OF HEREDITARY FACTORS IN FORMATION OF COMPLICATIONS IN PATIENTS WITH CHRONIC PANCREATITIS
- Authors: Vinokurova L.V.1, Shulyatev I.S.1, Dubtsova E.A.1, Agafonov M.A.1
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Affiliations:
- Moscow Clinical Research Center
- Issue: No 3 (2016)
- Pages: 48-52
- Section: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/277733
- ID: 277733
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Open Access
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Abstract
The mutations having impact on a condition of a pancreas are described. Research objective: to reveal mutations of SPINK1 N34S, PRSS1, R122H and CFTR, a mutation of del508 and Gly542Ter in group of patients with pancreas diseases. The 150 people with pancreas pathology are examined: 75 patients -with alcoholic pancreatitis, 41 patients - idiopathic pancreatitis, 17 patients - biliary pancreatitis, 2 - the autoimmune pancreatitis, 7 patients were operated concerning a pancreas cancer and 8 patients were operated concerning a mucous cystadenoma. It was noticed that existence of mutations in genes of PRSS1 and SPINK1 influenced on alcoholic and idiopathic pancreatitis formation. High occurrence of many mutations at patients with mucous cystadenoma was found, this fact demands further researches. The most frequent formation of cysts is noted at a mutation in PRSS1 gene and also in a combination with a mutation in a gene of SPINK1 N34S.
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About the authors
Ludmila Vasilevna Vinokurova
Moscow Clinical Research Center
Email: vinokurova520mail.ru
MD, Leading Research Fellow of Department of Pathology of the pancreas and biliary tract 111123 Moscow, 86, Entuziastov rd
Ilya Sergeevich Shulyatev
Moscow Clinical Research Center
Email: shuliatev@yandex.ru
PhD, Head of Laboratory of Genetics 111123 Moscow, 86, Entuziastov rd
Elena Anatolevna Dubtsova
Moscow Clinical Research Center
Email: e.dubtsova@mknc.ru
MD, Head of Department of Pathology of the pancreas and biliary tract 111123 Moscow, 86, Entuziastov rd
Maxim Alexadrovich Agafonov
Moscow Clinical Research Center
Email: referent509@yandex.ru
Junior Research Fellow of Department of Pathology of the pancreas and biliary tract 111123 Moscow, 86, Entuziastov rd
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