Cascade Correa: a paradigm ofview (literary review)


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Purpose of the review. Analysis of the Correa cascade. Overview of morphological types of atrophy, intestinal metplasia and dysplasia of the gastric mucosa (GM), as stages of gastro-carcinogenesis. Basic provisions. The Correa cascade is the sequential development of gastric adenocarcinoma by the progression of precancerous changes in the GM. Stages of the Correa cascade - atrophy, intestinal metaplasia and dysplasia - are considered as precancerous changes in the coolant, the triggering mechanism of which is the seeding of Helicobacter pylori GM. Thanks to the developed systems for assessing the mucosal condition in chronic gastritis, as well as the molecular and biological and genetic studies conducted, the Correa cascade received a clear morphological characterization of development at each stage, which makes it possible to develop a consistent plan for the management of patients for the purpose of cancer prevention. Сonclusion. The Correa cascade is the sequential development of gastric adenocarcinoma by the progression of precancerous changes in the GM. Eradication therapy in patients with premalignant changes in the gastric mucosa can reduce the risk of developing gastric cancer. Patients with H. pylori gastro-necrogenesis requires dynamic observation and treatment depending on the level of detected morphological changes.

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作者简介

Galina Belova

Multidisciplinary Medical Center of the Bank of Russia

Email: belovagv@inbox.ru
MD, head of the polyclinic

Oksana Rudenko

Multidisciplinary Medical Center of the Bank of Russia

Email: rudenkoos@mail.ru
endoscopy doctor of the endoscopic department

参考

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