Case of primary antiphospholipid syndrome complicated by thrombotic kidney microangiopathy of with infective endocardite addition


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Abstract

Antiphospholipid syndrome (AFS) is a symptom complex, which is manifested by thrombosis of vessels of different localization and caliber with obligatory presence of antiphospholipid antibodies in the blood. AFS is an acquired thrombophilic disease in which autoantibodies are produced not to the phospholipids of cell membranes per se, but to proteins interacting with phospholipids. This syndrome can affect several organ systems, so the problem of AFS is multidisciplinary. Clinical manifestations of AFS are quite nonspecific (thrombosis of different localization), therefore the diagnosis can be verified only by the presence of antiphospholipid antibodies. The presented clinical example illustrates the difficulties of diagnosing a disease that has occurred with the syndrome of renal failure and complicated by infective endocarditis.

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About the authors

Vladimir Y. Titov

FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia

Email: avdtitov@gmail.com
6th year student of the general medicine faculty

Ksenia V. Komissarova

FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia

Email: komissarova_kv@mail.ru
6th year student of the general medicine faculty

Darya A. Poddubnaya

FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia

Email: dary-pod@yandex.ru
6th year student of the general medicine faculty

Alina B. Egorkina

FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia

Email: alina.egorkina.94@mail.ru
6th year student of the general medicine faculty

Lilia M. Mamoyeva

FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia

attending physician of the Hospital therapy Department №1

Natalia A. Sokolova

State Budgetary Healthcare Institution O.M. Filatov state clinical hospital № 15 of the Healthcare Department, Moscow

Email: natalasocolova.94@mail.ru
MD, head of the 8th cardiology Department

Ekaterina T. Razumova

FSBEI of Higher Education «N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia

Email: razumova@yandex.ru
PhD, Associate Professor of the Department of Hospital Therapy No. 1

Valentin A. Kokorin

FSBEI of Higher Education "N.I. Pirogov Russian national research medical university» of the Ministry of Healthcare of Russia

Email: valentinkokorin@yahoo.com
PhD, associate professor of the hospital therapy Department No. 1

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