Combined drug therapy of post-traumatic osteoarthritis: data from a three-year prospective study
- Authors: Trofimov E.A.1, Mazurov V.I.1
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Affiliations:
- North-Western State Medical University named after I.I. Mechnikov of the Ministry of Healthcare of Russia
- Issue: Vol 7, No 4 (2021)
- Pages: 155-161
- Section: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/288239
- DOI: https://doi.org/10.18565/therapy.2021.4.155-161
- ID: 288239
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Abstract
As a part of the original research we performed MRI T2-mapping for the structural changes tracking on the early stages of post-traumatic knee osteoarthritis. It was found that at this stage of the disease a significant importance is not only the formation of osteophytes but also a decrease in the bonds number between the collagen-proteoglycan complex and water molecules, reflected by such an important parameter as a change in the relaxation time of the T2-signal, which is detected using the T2-mapping technique. During the 36-month study, we evaluated the influence of combined schemes of osteoarthritis therapy with the disease-modifying drugs on the clinical manifestations, as well as on the X-ray parameters of the early stages of the disease. Combined therapy with the usage of SYSADOA leads to a significant clinical improvement in accordance with the questionnaires data and slows the chrondrodegeneration progression in regard to the MRI data with the usage of color T2-mapping of cartilage.
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About the authors
Evgeniy A. Trofimov
North-Western State Medical University named after I.I. Mechnikov of the Ministry of Healthcare of Russia
Email: kafterrevm@szgmu.ru
PhD, associate professor of the Department of therapy, rheumatology, examination of temporary disability and medical care quality named after E.E. Eichwald 191015, Saint Petersburg, 41 Kirochnaya Str
Vadim I. Mazurov
North-Western State Medical University named after I.I. Mechnikov of the Ministry of Healthcare of Russia
Email: kafterrevm@szgmu.ru
MD, professor, academician of RAS, head of the Department of therapy, rheumatology, examination of temporary disability and medical care quality named after E.E. Eichwald 191015, Saint Petersburg, 41 Kirochnaya Str
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