Association of some polymorphisms with QT interval duration in men


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Abstract

The study of predictors of life-threatening cardiac arrhythmias and sudden cardiac death development is still of considerable interest. The aim of the research was to study the association of some molecular genetic markers with QT interval duration in male patients. Material and methods. The study included 25-69 years old male patients (samples formed from 2003 to 2017 within the framework of the international HAPIEE project and screening of young people 25-44 years old). They were divided into groups with the shortest, average and longest QT interval. The following single nucleotide polymorphisms (SNPs) were selected for genotyping: rs1805124, rs11720524, rs11756438, rs12576239. Results. There were revealed no statistically significant differences between the groups in the frequencies of the SNP genotypes rs1805124, rs12576239. In carriers of the CC and GG genotypes rs11720524 in the model CG vs. CC+GG, higher QT values were recorded comparatively to carriers of the CG genotype (p=0,025). The AA genotype SNP rs11756438 of the CEP85L gene in the group of men with an average QT interval was found in 31,6% of men and in 21,5% of patients with a short QT interval (OR=0,59; 95% CI: 0,366-0,956; p=0,031). Conclusion. Rs11720524 of the SCN5A gene and rs11756438 of the CEP85L gene are associated with QT interval duration. The association of SNP rs1805124 of the SCN5A gene, rs12576239 of the KCNQ1 gene has not been confirmed.

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About the authors

A. M Nesterets

Research Institute of Therapy and Preventive Medicine - a Branch of Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

Email: alinvaleeva1994@gmail.com
630089, Novosibirsk, 175/1 Borisa Bogatkova Str. Tel.: +7 (953) 869-34-34

A. A Kuznetsov

Research Institute of Therapy and Preventive Medicine - a Branch of Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

Email: kuznetsoviimed@gmail.com
630089, Novosibirsk, 175/1 Borisa Bogatkova Str. Tel.: +7 (953) 869-34-34

A. A Ivanova

Research Institute of Therapy and Preventive Medicine - a Branch of Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

Email: ivanova_a_a@mail.ru
630089, Novosibirsk, 175/1 Borisa Bogatkova Str. Tel.: +7 (953) 869-34-34

A. A Gurazheva

Research Institute of Therapy and Preventive Medicine - a Branch of Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

Email: annapalna1@mail.ru
630089, Novosibirsk, 175/1 Borisa Bogatkova Str. Tel.: +7 (953) 869-34-34

S. K Maliutina

Research Institute of Therapy and Preventive Medicine - a Branch of Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

Email: smalyutina@hotmail.com
630089, Novosibirsk, 175/1 Borisa Bogatkova Str. Tel.: +7 (953) 869-34-34

D. V Denisova

Research Institute of Therapy and Preventive Medicine - a Branch of Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

Email: denisovadiana@gmail.com
630089, Novosibirsk, 175/1 Borisa Bogatkova Str. Tel.: +7 (953) 869-34-34

V. N Maksimov

Research Institute of Therapy and Preventive Medicine - a Branch of Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

Email: medik11@mail.ru
630089, Novosibirsk, 175/1 Borisa Bogatkova Str. Tel.: +7 (953) 869-34-34

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