Antibiotic-associated diarrhea in modern realities


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Abstract

Antibiotic-associated diarrhea (AAD) is one of the undesirable effects of antibiotic therapy. Recently, however, the relevance of AAD has become particularly important due to the increase in morbidity and mortality against the backdrop of the COVID-19 pandemic. There are several mechanisms for the formation of diarrhea when taking antibacterial drugs, among which infectious AAD has the most unfavorable course. The article discusses the features of the clinical course of diarrhea, characteristic of different pathogens. Literature data on the risk factors for the occurrence of AAD, the features of the course of the disease in children and adults are given. Approaches to the diagnosis and treatment of diarrhea in COVID-19 are highlighted. The provisions of the recommendations of the Russian Gastroenterological Association for the treatment of Clostridium difficile-associated disease are presented. Particular attention is paid to the review of recent literature on the use of probiotics for the prevention of AAD.

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About the authors

Elena V. Luzina

Chita State Medical Academy of the Ministry of Healthcare of Russia

PhD in Medicine, associate professor of the Department of therapy of FAPE

Natalia V. Lareva

Chita State Medical Academy of the Ministry of Healthcare of Russia

Dr. med. habil., professor, vice-rector for scientific and international affairs, head of the Department of therapy of FAPE

Albina A. Zhilina

Chita State Medical Academy of the Ministry of Healthcare of Russia

PhD in Medicine, associate professor of the Department of therapy of FAPE

Evgenia B. Zhigzhitova

Chita State Medical Academy of the Ministry of Healthcare of Russia

PhD in Medicine, assistant at the Department of therapy of FAPE

Elena A. Tomina

Chita State Medical Academy of the Ministry of Healthcare of Russia

PhD in Medicine, assistant at the Department of therapy of FAPE

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