Adjuvant-associated systemic lupus erythematosus with urticarian vasculitis and sarcoid-like granulomas formation

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Abstract

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is one of the little-studied interdisciplinary problems of modern therapy. The article presents a clinical observation in which a 42-year-old female patient had a development of systemic lupus erythematosus with urticarial syndrome and sarcoid-like granulomas as a variant of ASIA after implantation of silicone breast implants and multiple intradermal injections of adjuvants. The data of the abovementioned observation are compared with the data of scientific publications, which consider the complex pathogenetic mechanisms of the formation of the immune response after the placement of adjuvants into human tissues.

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About the authors

Inna Z. Gaydukova

I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatological Hospital No. 25

Author for correspondence.
Email: ubp1976@list.ru
ORCID iD: 0000-0003-3500-7256
SPIN-code: 3083-7996

MD, professor, deputy director of the Research Institute of Rheumatology and professor of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, rheumatologist

Russian Federation, Saint Petersburg; Saint Petersburg

Tatyana E. Skvortsova

I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia

Email: Tatyana.Skvortcova@szgmu.ru
ORCID iD: 0000-0002-9362-9961

PhD in Medical Sciences, associate professor of the Department of propaedeutics of internal diseases, gastroenterology and dietetics named after S.M. Ryss

Russian Federation, Saint Petersburg

Sergei L. Vorobyov

National Center for Clinical Morphological Diagnostics LLC

Email: ubp1976@list.ru

PhD in Medical Sciences, pathologist of the highest category, head of the morphological diagnostics of oncological diseases, diseases of the gastrointestinal tract, endocrine organs, supervisor

Russian Federation, 192283, Saint Petersburg, 8 Oleko Dundicha Str.

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