Mixed infection with hepatitis A and E in combination with hemorrhagic fever with renal syndrome

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Abstract

On the territory of Russia, there are regions-enclaves for HEV, such as the Belgorod region, where increased incidence rates and a high prevalence of anti-HEV antibodies in the population are recorded. Anti-HEV IgG antibodies are often found in men over 60 with chronic liver disease. We have presented a rare description of a variant of a severe course of infection with autochthonous hepatitis E and A in a young woman. The analysis of the presented clinical observation indicates the need for a comprehensive differential diagnostic approach in the management of patients. The patient showed signs of hemorrhagic organ damage, proteinuria, with detection of Hantavirus markers in ELISA, which makes it possible to diagnose hemorrhagic fever with renal syndrome. We wanted to draw attention to the increase in the spread of severe mixed infection and to diagnose cases suspected of acute viral hepatitis in a timely manner.

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About the authors

Margarita A. Shiryaeva

Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia

Email: r.schiryaeva@yandex.ru

2nd year resident of the Department of virology, Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia

Russian Federation, Moscow,19/38 Belomorskaya Str.

Natalia N. Lebedeva

Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia

Author for correspondence.
Email: lebedevanatalya@rocketmail.com

PhD in Medical Sciences, associate professor of the Department of virology, Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia

Russian Federation, Moscow,19/38 Belomorskaya Str.

Alexander E. Baranov

E.N. Pavlovsky Infectious Clinical Hospital

Email: r.schiryaeva@yandex.ru

PhD in Medical Sciences, chief physician of E.N. Pavlovsky Infectious Clinical Hospital, associate professor of the Department of infectious diseases of the Faculty of general medicine, Belgorod State National Research University

Russian Federation, 308023, Belgorod,122 Sadovaya Str.

Alina A. Agarkova

E.N. Pavlovsky Infectious Clinical Hospital

Email: agarkova-31@mail.ru

PhD in Medical Sciences, assistant at the Department of hospital therapy, Belgorod State National Research University, deputy chief physician for clinical and expert work of E.N. Pavlovsky Infectious Clinical Hospital

Russian Federation, 308023, Belgorod,122 Sadovaya Str.

Elena Yu. Malinnikova

Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia

Email: virusrmapo@rambler.ru

MD, head of the Department of virology, Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia

Russian Federation, 125445, Moscow,19/38 Belomorskaya Str.

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