Pathogenetic therapy in case of COVID-19: decreasing of key hyper inflammatory response factors production

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Novel coronavirus infection has led to high morbidity and mortality throughout the whole world. There are several genovariants of the SARS-CoV-2 virus, including Delta (B.1.617.2) and Omicron (B.1.1.529). Delta variant is associated with more severe course of infection, while Omicron resulted in a significant increase in the total number of infected individuals. Upper respiratory tract damage symptoms and fever remain the most common symptoms of COVID-19, but extrapulmonary complications affecting the cardiovascular, central nervous system, and gastrointestinal tract may also develop. Proactive treatment before the full symptom complex of life-threatening conditions (pneumonia, ARDS, sepsis) develops is a major challenge in COVID-19 control. Prescribing of medicines that can reduce the production of key factors of the hyperinflammatory response in COVID-19, in particular cytokines interleukin 6 and interleukin 8, could be considered to be a promising direction in pathogenetic therapy of the disease.

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Sobre autores

Svetlana Nikolaeva

Central Research Institute of Epidemiology of Rospotrebnadzor

Autor responsável pela correspondência
Email: nikolaeva008@list.ru

MD., leading researcher at the clinical Department of infectious pathology

 

Rússia, 3a Novogireevskaya Str., 111123, Moscow

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