Modern aspects of the use of local hyaluronic acid in musculoskeletal diseases

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Abstract

Musculoskeletal pathology is one of the main medical and social problems in modern healthcare and are the most common cause of chronic pain. Osteoarthritis (OA) and periarticular soft tissues pathologies are prominent examples of this group of diseases. The main goals of their treatment include reducing pain, improving the functional condition and preventing the development of joint deformity, improving the quality of life of patients, as well as minimizing the side effects of pharmacotherapy. Local therapy with the use of hyaluronic acid is considered to be a promising direction in therapeutic interventions for these diseases. Numerous meta-analyses have shown that hyaluronic acid is well tolerated and has a full therapeutic effect (pain reduction, improved joint function) comparatively with placebo and other remedies. Currently, new data are appearing on the use of hyaluronic acid in case of periarticular tissues pathologies, which indicates the need for a more in-depth study of this method of therapy. Current review discusses modern aspects of the local application of hyaluronic acid in osteoarthritis and periarticular soft tissues pathologies.

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About the authors

Ekaterina A. Strebkova

V.A. Nasonova Research Institute of Rheumatology

Email: dr.ekaterinastrebkova@yandex.ru
ORCID iD: 0000-0001-8130-5081

PhD in Medical Sciences, Researcher, Department of Metabolic Diseases of Bones and Joints, Laboratory of Osteoarthritis

Russian Federation, 115522, Moscow,34А Kashirskoe Highway

Lyudmila I. Alekseeva

V.A. Nasonova Research Institute of Rheumatology

Author for correspondence.
Email: dr.ekaterinastrebkova@yandex.ru
ORCID iD: 0000-0001-7017-0898

MD, professor, head of the Department of metabolic diseases of bones and joints of the Laboratory of osteoarthritis

Russian Federation, 115522, Moscow,34А Kashirskoe Highway

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