Indicators of systemic inflammation and state of the cardiovascular system in patients with chronic kidney disease
- Authors: Zhmurov D.V.1, Zhmurov V.A.1, Petrov I.M.1, Petelina T.I.2, Gapon L.I.2, Yaroslavskaya E.I.2, Petrova Y.A.1, Oskolkov S.A.1, Zhmurova E.A.1, Vanuito E.Y.1, Ermakova A.A.1, Ermakova P.A.1
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Affiliations:
- Tyumen State Medical University of the Ministry of Healthcare of Russia
- Tyumen Cardiological Research Center – a branch of Tomsk National Research Medical Center of the Russian Academy of Sciences
- Issue: Vol 9, No 3 (2023)
- Pages: 15-20
- Section: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/508776
- DOI: https://doi.org/10.18565/therapy.2023.3.15–20
- ID: 508776
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Abstract
Chronic kidney disease (CKD) through cardiovascular risks and end-stage renal disease development affects the global morbidity and mortality burden worldwide.
The aim of the study is to characterize the indicators of systemic inflammation in correlation with cardiovascular system changes in CKD patients.
Material and methods. 150 patients with CKD were examined. All participants of the research were divided into 2 groups: patients with CKD without cardiovascular disease (CVD, n=75); and CKD patients with CVD (n=75). The groups differed significantly in SBP, DBP, HR, BMI (p <0,001). Special research methods included the determination of the level of interleukins (IL-1, IL-6, IL-8), TNF-α, fibroblast proliferation factor (TgFb1) and highly sensitive CRP.
Results. In examined patients with CKD and CVD, there was found an increase in the level of IL-1, IL-6, TNF-α, as well as a tendency for increase of TgFb1 level and decrease of IL-8 comparatively with CKD patients without CVD. It was fixed an increase of cystatin C level and microalbuminuria among patients with CVD comparatively with the group without CVD.
Conclusion. Pathological processes laying in CKD basis are accompanied by an increase in the level of pro-inflammatory cytokines. The results obtained can serve as a prerequisite for improving the pathogenetic therapy of CKD with cardiovascular manifestations.
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About the authors
Denis V. Zhmurov
Tyumen State Medical University of the Ministry of Healthcare of Russia
Author for correspondence.
Email: zhmdenis@yandex.ru
ORCID iD: 0000-0003-3167-5310
PhD in Medical Sciences, Associate Professor of the Department of Propaedeutics of Internal Diseases
Russian Federation, TyumenVladimir A. Zhmurov
Tyumen State Medical University of the Ministry of Healthcare of Russia
Email: zhmurovva@yandex.ru
ORCID iD: 0000-0002-7228-6197
MD, Professor, Head of the Department of Propaedeutics Of Internal Diseases
Russian Federation, TyumenIvan M. Petrov
Tyumen State Medical University of the Ministry of Healthcare of Russia
Email: zhmdenis@yandex.ru
MD, Associate Professor, Head of the Department of Medical Informatics and Biological Physics with the UNESCO Bioethics Network Section
Russian Federation, TyumenTatyana I. Petelina
Tyumen Cardiological Research Center – a branch of Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: zhmdenis@yandex.ru
MD, Leading Researcher at the Department of Arterial Hypertension and Coronary Insufficiency of the Scientific Department of Clinical Cardiology
Russian Federation, TyumenLyudmila I. Gapon
Tyumen Cardiological Research Center – a branch of Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: zhmdenis@yandex.ru
MD, Professor, Head of the Scientific Department of Clinical Cardiology, Scientific Director of the Department of Arterial Hypertension
Russian Federation, TyumenElena I. Yaroslavskaya
Tyumen Cardiological Research Center – a branch of Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: zhmdenis@yandex.ru
MD, Head of the Laboratory of Instrumental Diagnostics
Russian Federation, TyumenYulianna A. Petrova
Tyumen State Medical University of the Ministry of Healthcare of Russia
Email: zhmdenis@yandex.ru
PhD in Medical Sciences, Associate Professor of the Department of Propaedeutics of Internal Diseases
Russian Federation, TyumenSergey A. Oskolkov
Tyumen State Medical University of the Ministry of Healthcare of Russia
Email: zhmdenis@yandex.ru
MD, Professor of the Department of Propaedeutics of Internal Diseases
Russian Federation, TyumenEkaterina A. Zhmurova
Tyumen State Medical University of the Ministry of Healthcare of Russia
Email: zhmdenis@yandex.ru
2nd year Attending Physician at the Department of Internal Medicine, Polyclinic Therapy and Family Medicine
Russian Federation, TyumenEvgeniy Ya. Vanuito
Tyumen State Medical University of the Ministry of Healthcare of Russia
Email: zhmdenis@yandex.ru
Postgraduate Student of the Department of Propaedeutics of Internal Diseases
Russian Federation, TyumenAnna A. Ermakova
Tyumen State Medical University of the Ministry of Healthcare of Russia
Email: zhmdenis@yandex.ru
6th year Student, Institute of Clinical Medicine, Department of Propaedeutics of Internal Diseases
Russian Federation, TyumenPolina A. Ermakova
Tyumen State Medical University of the Ministry of Healthcare of Russia
Email: zhmdenis@yandex.ru
6th year Student, Institute of Clinical Medicine, Department of Propaedeutics of Internal Diseases
Russian Federation, TyumenReferences
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