Modern concepts concerning the mechanisms of iron absorption: activators, inhibitors, regulation, new possibilities of optimization

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Abstract

The article presents current literature data on the mechanisms of iron absorption, activators and inhibitors of this process. Authors are analyzing the published data on the study of the regulation of iron entry into the blood, processes that stimulate and inhibit its absorption, describing in details hepcidin–erythroferron mechanism for iron metabolism controlling. Separately, there are provided the data on food products, nutritional supplements, existing and under study new drugs that change the degree of resorption of iron into intestinal cells, suppressing and potentiating the effect of hepcidin. Scientific studies on a new oral form of sucrosomial Iron, findings on the mechanisms of its absorption, peculiarities of use, and the results of biological and clinical studies are considered.

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About the authors

Nikolai I. Stuklov

Peoples’ Friendship University of Russia

Author for correspondence.
Email: stuklovn@gmail.com
ORCID iD: 0000-0002-4546-1578

MD, professor of the Department of hospital therapy with courses of endocrinology, hematology and clinical laboratory diagnostics of the Medical Institute

Russian Federation, Moscow

Anna A. Gurkina

Peoples’ Friendship University of Russia

Email: enmitchell07@gmail.com
ORCID iD: 0000-0003-4164-0058

assistant at the Department of hospital therapy with courses of endocrinology, hematology and clinical laboratory diagnostics of the Medical Institute

Russian Federation, Moscow

Maksim S. Kovalchuk

Peoples’ Friendship University of Russia

Email: HDCX93@gmail.com
ORCID iD: 0000-0002-3847-504X

postgraduate student of the Department of hospital therapy with courses of endocrinology, hematology and clinical laboratory diagnostics of the Medical Institute

Russian Federation, Moscow

Nikolai D. Kisly

Peoples’ Friendship University of Russia

Email: kislyy-nd@rudn.ru
ORCID iD: 0000-0003-2988-2054

MD, professor, head of the Department of hospital therapy with courses of endocrinology, hematology and clinical laboratory diagnostics of the Medical Institute

Russian Federation, Moscow

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