Correction of electrical instability of the myocardium at recurrent tonsillitis
- Authors: Zorkina A.V.1, Sipyagina M.K.2, Zorkin M.V.1, Skopina Y.A.1
-
Affiliations:
- N.P. Ogarev National Research Mordovia State University
- Federal Scientific and Clinical Center of FMBA of Russia
- Issue: Vol 9, No 8 (2023)
- Pages: 8-13
- Section: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/624608
- DOI: https://doi.org/10.18565/therapy.2023.8.8–13
- ID: 624608
Cite item
Open Access
Access granted
Abstract
A number of studies have clearly demonstrated an increase in the effectiveness of therapy for a number of infectious diseases with the additional use of antioxidants as part of complex therapy.
The objective of the work is to assess the parameters of bioelectrical activity of the myocardium in patients with recurrent tonsillitis against the background of the introduction of ethylmethylhydroxypyridine succinate into complex therapy.
Material and methods. All patients were undergoing inpatient treatment in the infectious diseases hospital. ECG was recorded upon admission and discharge of patients. Patients were divided into two groups. Group 1 received standard basic therapy, group 2 was additionally prescribed ethylmethylhydroxypyridine succinate 5% 4,0 ml IV drip No. 5. The average, minimum, maximum duration of the P wave, PQ, QT intervals were assessed. The duration of QT, corrected by heart rate (QTc), dispersion of indicators DР, DРQ, DQT, DQTс were calculated. The results obtained were assessed depending on the preserved or reduced ejection fraction (EF) according to echocardioscopy.
Results and conclusion. Upon admission, the indicators QTc, DP, DPQ, DQT, DQTc exceeded those of healthy volunteers. By the time of discharge, in patients of group 1, the studied indicators remained at the same high level (with EF <55%) or even significantly increased (with EF >55%), despite the treatment. This proved the preservation of arrhythmogenic readiness of the myocardium. In patients of group 2, there was a decrease in indicators and achievement of the level of healthy volunteers, including patients with an initially reduced ejection fraction.
Full Text
About the authors
Angelina V. Zorkina
N.P. Ogarev National Research Mordovia State University
Author for correspondence.
Email: wind-lina@mail.ru
ORCID iD: 0000-0003-1122-9532
MD, professor, professor of the Department of outpatient therapy, N.P. Ogarev National Research Mordovia State University
Russian Federation, SaranskMaria K. Sipyagina
Federal Scientific and Clinical Center of FMBA of Russia
Email: Sipjaginy@mail.ru
ORCID iD: 0009-0000-2530-552X
PhD in Medical Sciences, functional diagnostics doctor at Federal Scientific and Clinical Center of FMBA of Russia
Russian Federation, MoscowMikhail V. Zorkin
N.P. Ogarev National Research Mordovia State University
Email: saerdan@mail.ru
ORCID iD: 0000-0002-1862-6613
PhD in Medical Sciences, associate professor of the Department of outpatient therapy, N.P. Ogarev National Research Mordovia State University
Russian Federation, SaranskYulia A. Skopina
N.P. Ogarev National Research Mordovia State University
Email: skopina@bk.ru
ORCID iD: 0000-0001-7598-5690
PhD in Medical Sciences, associate professor of the Department of outpatient therapy, N.P. Ogarev National Research Mordovia State University
Russian Federation, SaranskReferences
- Ускова Ю.Г., Павелкина В.Ф., Альмяшева Р.З. Значение активации процессов липопероксидации в патогенезе геморрагической лихорадки с почечным синдромом. Академический журнал Западной Сибири. 2014; 10(1): 51. [Uskova Yu.G., Pavelkina V.F., Almjasheva R.Z. The significance of the activation of lipoperoxidation processes in the pathogenesis of hemorrhagic fever with renal syndrome. Akademicheskiy zhurnal Zapadnoy Sibiri = Academic Journal of Western Siberia. 2014; 10(1): 51 (In Russ.)]. EDN: SASJFT.
- Мирекина Е.В., Галимзянов Х.М., Бедлинская Н.Р. Роль дисбаланса оксидантно-антиоксидантной системы в развитии гемокоагуляционных нарушений при некоторых инфекционных заболеваниях. Астраханский медицинский журнал. 2017; 12(2): 15–22. [Mirekina E.V., Galimzyanov H.M., Bedlinskaya N.R. The role of the imbalance of the oxidant-antioxidant system in the development of hemocoagulation disorders in certain infectious diseases. Astrakhanskiy meditsinskiy zhurnal = Astrakhan Medical Journal. 2017; 12(2): 15–22 (In Russ.)]. EDN: ZEULEF.
- Dikici I., Mehmetoglu I., Dikici N. et al. Investigation of oxidative stress and some antioxidants in patients with acute and chronic viral hepatitis B and the effect of interferon-alpha treatment. Clin Biochem. 2005; 38(12): 1141–44. https://dx.doi.org/10.1016/j.clinbiochem.2005.10.006.
- Afanasyeva G.A., Chesnokova N.P. On lipid peroxidation process activation role in bacterial endotoxicosis pathogenesis. Modern Problems of Science and Education. 2008; (3): 49–52.
- Шепелев А.П., Корниенко И.В., Шестопалов А.В., Антипов А.Ю. Роль процессов свободнорадикального окисления в патогенезе инфекционных болезней. Вопросы медицинской химии. 2000; 46(2): 110–116. [Shepelev A.P., Kornienko I.V., Shestopalov A.V., Antipov A.Ju. The role of lipids peroxidation processes in the pathogenesis of infectious diseases. Voprosy meditsinskoy khimii = Issues of Medicinal Chemistry. 2000; 46(2): 110–116 (In Russ.)]. EDN: SWJVKJ.
- Павелкина В.Ф., Ласеева М.Г., Альмяшева Р.З., Амплеева Н.П. Геморрагическая лихорадка с почечным синдромом: новые возможности патогенетической терапии. Академический журнал Западной Сибири. 2013; 9(4): 91–92. [Pavelkina V.F., Laseeva M.G., Almyasheva R.Z., Ampleeva N.P. Hemorrhagic fever with renal syndrome: New possibilities of pathogenetic therapy. Akademicheskiy zhurnal Zapadnoy Sibiri = Academic Journal of Western Siberia. 2013; 9(4): 91–92 (In Russ.)]. EDN: QZFJOP.
- Павелкина В.Ф., Альмяшева Р.З., Амплеева Н.П., Ускова Ю.Г. Активность процессов перекисного окисления липидов и их коррекция при гастроинтестинальной форме сальмонеллеза. Научный альманах. 2015; (2): 139–143. [Pavelkina V.F., Almyasheva R.Z., Ampleeva N.P., Uskova Yu.G. Activity of lipid peroxidation processes and their correction with gastrointestinal form of salmonellosis. Nauchnyy al’manakh = Scientific Almanac. 2015; (2): 139–143 (In Russ.)]. https://dx.doi.org/10.17117/na.2015.02.139. EDN: TXZGYH.
- Павелкина В.Ф., Альмяшева Р.З., Амплеева Н.П. Новые возможности патогенетической терапии гриппа. Академический журнал Западной Сибири. 2013; 9(5): 59–60. [Pavelkina V.F., Almyasheva R.Z., Ampleeva N.P. New possibilities of pathogenetic therapy of influenza. Akademicheskiy zhurnal Zapadnoy Sibiri = Academic Journal of Western Siberia. 2013; 9(5): 59–60 (In Russ.)]. EDN: REZFCL.
- Кравченко И.Э., Гармонов С.Ю., Зарипова Р.Г.с соавт. Оценка фенотипа ацетилирования у больных ангиной на фоне базисной терапии и лечения ксимедоном. Вопросы биологической, медицинской и фармацевтической химии. 2006; (4): 22–25. [Kravchenko I.E., Garmonov S.Yu., Zaripova R.G. et al. Evaluation of acetylation phenotype in patients with tonsillitis during basic therapy and xymedon treatment. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii = Issues of Biological, Medicinal and Pharmaceutical Chemistry. 2006; (4): 22–25 (In Russ.)]. EDN: HYLXYP.
- Кравченко И.Э., Гармонов С.Ю., Зарипова Р.Г. с соавт. Оценка метаболических систем ацетилирования и окисления у больных стрептококковыми ангинами и их терапевтическая коррекция ксимедоном. Казанский медицинский журнал. 2008; 89(4): 452–457. [Kravchenko I.E., Garmonov S.Yu., Zaripova R.G. et al. Assessment of metabolic systems of acetylation and oxidation in patients with streptococcal angina and their therapeutic correction with xymedon. Kazanskiy meditsinskiy zhurnal = Kazan Medical Journal. 2008; 89(4): 452–457 (In Russ.)]. EDN: JXYKRV.
- Павелкина В.Ф., Ласеева М.Г. Интоксикационный синдром и его коррекция при рецидивирующих стрептококковых ангинах. Вестник оториноларингологии. 2012; (3): 83–87. [Pavelkina V.F., Laseeva M.G. Intoxication syndrome concomitant with recurrent streptococcal tonsillitis and its correction. Vestnik otorinolaringologii = Bulletin of Otorhinolaryngology. 2012; (3): 83–87 (In Russ.)]. EDN: TEUJLL.
- Прокофьев А.Б., Руднев С.Г., Маринин В.Ф., Кукес И.В. Значение современных методов функциональной диагностики в клинических исследованиях лекарственных средств, применяемых в кардиологической практике. Ведомости Научного центра экспертизы средств медицинского применения. Регуляторные исследования и экспертиза лекарственных средств. 2014; (3): 19–23. [Prokofiev A.B., Rudnev S.G., Marinin V.F., Kukes I.V. The importance of modern methods of functional diagnostics in clinical trials of medicines used in cardiology practice. Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo primeneniya. Regulyatornyye issledovaniya i ekspertiza lekarstvennykh sredstv = Bulletin of the Scientific Center for the Examination of Medical Products. Regulatory Research and Examination of Medicines. 2014; (3): 19–23 (In Russ.)]. EDN: SQIQWT.
Supplementary files
