Levels of interleukins 1β, 23, osteoprotegerin, receptor activator of nuclear factor-kappa B ligand in the dynamics of hypoxytherapy performing in female patients with autoimmune thyroiditis
- Authors: Ignatenko G.A.1, Maylyan E.A.1, Ignatenko T.S.1, Lesnichenko D.A.1, Valigun Y.S.1, Tumanova S.V.1
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Affiliations:
- M. Gorky Donetsk State Medical University
- Issue: Vol 9, No 9 (2023)
- Pages: 54-61
- Section: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/626127
- DOI: https://doi.org/10.18565/therapy.2023.9.54-61
- ID: 626127
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Abstract
Chronic autoimmune thyroiditis (AIT) is a common autoimmune pathology. Replacement therapy with thyroid hormone drugs (HRT) does not always normalize the patient’s condition, so the introduction of innovative methods of treating AIT with hypothyroidism, which includes interval hypoxic therapy, is becoming quite actual.
The aim: to study the effects of interval hypoxytherapy at the levels of interleukin 1β (IL-1β), IL-23, osteoprotegerin (OPG) and ligand of nuclear factor κB receptor activator (RANKL) in AIT female patients with hypothyroidism.
Material and methods. 136 females with initially diagnosed AIT and hypothyroidism received HRT for 12 months. Among them there were 68 participants, who, along with HRT, underwent sessions of interval hypoxic therapy. Serum levels of IL-1β, IL-23, OPG and RANKL were measured.
Results. Both isolated HRT and its combination with hypoxytherapy did not lead to significant changes in the level of OPG, RANKL and the value of their ratio in presence of a statistically significant decrease (p <0,001) in the initially increased concentration of IL-1β to the level of conditionally healthy women. Regardless of interval hypoxytherapy use, there was a decrease (p <0,0001) of the initially elevated IL-23 concentrations to the level of conditionally healthy females when using hypoxytherapy, and to a level higher than the value of the control group (p <0,01) in presence of isolated HRT.
Conclusion. 12-month course of HRT, either alone or in combination with interval hypoxytherapy, does not affect OPG and RANKL production. Regardless of the prescription of hypoxytherapy, the decrease of IL-1β and IL-23 levels (p <0,001) takes place in female patients. At the same time, normalization of IL-1β concentrations is observed in all females with AIT, and IL-23 levels reach control values only if interval hypoxytherapy is used.
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About the authors
Grigory A. Ignatenko
M. Gorky Donetsk State Medical University
Author for correspondence.
Email: prop-vnutr-medicina@dnmu.ru
ORCID iD: 0000-0003-3611-1186
MD, Professor, Corresponding Member of National Academy of Medical Sciences of Ukraine, Head of the Department of Propaedeutics of Internal Diseases
Russian Federation, DonetskEduard A. Maylyan
M. Gorky Donetsk State Medical University
Email: eduardmailyan095@gmail.com
ORCID iD: 0000-0003-2845-7750
MD, Professor, Head of the Department of Microbiology, Virology, Immunology and Allergology
Russian Federation, DonetskTatyana S. Ignatenko
M. Gorky Donetsk State Medical University
Email: prop-vnutr-medicina@dnmu.ru
ORCID iD: 0009-0001-2138-2277
MD, Professor, Professor of the Department of Propaedeutics of Internal Diseases
Russian Federation, DonetskDenis A. Lesnichenko
M. Gorky Donetsk State Medical University
Email: lesnichenko.da@yandex.com
ORCID iD: 0000-0003-4465-261X
PhD in Medical Sciences, Associate Professor, Associate Professor of the Department of Microbiology, Virology, Immunology and Allergology
Russian Federation, DonetskYanina S. Valigun
M. Gorky Donetsk State Medical University
Email: valigun.kdl@mail.ru
ORCID iD: 0009-0009-4364-1995
Assistant at the Department of Transplantology and Clinical Laboratory Diagnostics
Russian Federation, DonetskSvetlana V. Tumanova
M. Gorky Donetsk State Medical University
Email: sv.tumanova@mail.ru
ORCID iD: 0009-0006-5316-9813
PhD in Medical Sciences, Associate Professor, Associate Professor of the Department of Internal Medicine No. 2
Russian Federation, DonetskReferences
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