Diagnostic and therapeutic aspects of irisin in cardiovascular pathology and metabolic disorders

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Abstract

Despite significant advances in medicine, cardiovascular disease continues to be the leading cause of death worldwide. An important task of modern cardiology is the search and study of new cardiovascular biological markers. The purpose of the presented review is to analyze studies devoted to the study of irisin as a diagnostic and prognostic marker in cardiometabolic diseases. According to the results obtained, an important diagnostic and prognostic significance of the irisin assessment was revealed. Further studies will show the possibility of using this biomarker as an additional diagnostic and prognosis tool. Regulation of irisin concentration and expression may prove to be a promising strategy for the treatment of cardiac patients.

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About the authors

Amina M. Alieva

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Author for correspondence.
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-5416-8579

PhD in Medical Sciences, Associate Professor of the Department of Hospital Therapy named after Academician G.I. Storozhakov of the Faculty of General Medicine

Russian Federation, Moscow

Igor G. Nikitin

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: amisha_alieva@mail.ru
ORCID iD: 0000-0003-1699-0881

MD, Professor, Head of the Department of Hospital Therapy named after Academician G.I. Storozhakov of the Faculty of General Medicine

Russian Federation, Moscow

Natalya V. Teplova

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: amisha_alieva@mail.ru
ORCID iD: 0000-0002-7181-4680

MD, Professor, Head of the Department of Clinical Pharmacology of the Faculty of General Medicine

Russian Federation, Moscow

Irina E. Baykova

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: amisha_alieva@mail.ru
ORCID iD: 0000-0003-0886-6290

PhD in Medical Sciences, Associate Professor of the Department of Hospital Therapy named after Academician G.I. Storozhakov of the Faculty of General Medicine

Russian Federation, Moscow

Alik M. Rakhaev

Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labor and Social Protection of Russia

Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-9601-1174

MD, Head of the Expert Staff 

Russian Federation, Nalchik

Madina V. Kudaeva

Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labor and Social Protection of Russia

Email: amisha_alieva@mail.ru
ORCID iD: 0009-0003-9017-7191

Doctor for Medical and Social Expertise, Therapist at the Expert Staff 

Russian Federation, Nalchik

Malika R. Sozaeva

Kh.M. Berbekov Kabardino-Balkarian State University

Email: amisha_alieva@mail.ru
ORCID iD: 0009-0003-8949-0017

Student of the Faculty of Pediatrics

Russian Federation, Nalchik

Irina A. Kotikova

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-5352-8499

Student of the Faculty of General Medicine

Russian Federation, Moscow

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2. Fig. 1. Main intracellular signaling pathways of irisin

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3. Fig. 2. Additional intracellular signaling pathways of irisin

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