Estimation of the risk of cardiovascular events and adverse outcomes in patients with peripheral atherosclerosis
- Authors: Kobzeva N.D.1, Demidova A.A.1, Shlyk S.V.1, Martynov A.I.2, Shlyk I.F.1
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Affiliations:
- Rostov State Medical University of the Ministry of Healthcare of Russia
- Russian University of Medicine of the Ministry of Healthcare of Russia
- Issue: Vol 10, No 1 (2024)
- Pages: 21-29
- Section: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/630629
- DOI: https://doi.org/10.18565/therapy.2024.1.21-29
- ID: 630629
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Abstract
Abstract. Despite the fact that patients with simultaneous atherosclerotic lesions of various vascular beds are systematically registered in clinical practice, there is insufficient reliable data on the management of such kind of patients. It could be helpful to determine management tactics for that group of patients with a direct focus on the prevention of adverse cardiovascular events.
The aim: to develop a calculator for assessing the risk of cardiovascular events and adverse outcomes in patients with peripheral atherosclerosis during a three-year prospective observation, including data based on clinical and instrumental characteristics of endothelial function.
Material and methods. The study included 519 patients with atherosclerotic lesions of various vascular territories. The patients underwent a complex of laboratory tests and a number of instrumental tests, including (if indicated) coronary angiography, angiography of the renal, brachiocephalic and lower extremities arteries. During a prospective observation (36 months), the long-term prognosis of that group of individuals was assessed.
Results. Maximal discriminant significance according to the F-criterion when dividing patients depending on the risk of cardiovascular events and adverse outcomes developing had such indexes as the presence of hemodynamically significant peripheral atherosclerosis, value of the atherogenic index, value of glycated hemoglobin, gender of patients, age, biological vascular age and augmentation index value.
Conclusion. The developed calculator for assessing the risk of cardiovascular events and adverse outcomes developing allows us to highly accurately assess the probability of unfavorable long-term prognosis development in patients with peripheral atherosclerosis.
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About the authors
Natalia D. Kobzeva
Rostov State Medical University of the Ministry of Healthcare of Russia
Author for correspondence.
Email: kobzeva.nataliya1@gmail.com
ORCID iD: 0000-0002-3390-2452
MD, PhD (Medicine), associate professor of the Department of therapy with a course of outpatient therapy, Rostov State Medical University of the Ministry of Healthcare of Russia
Russian Federation, Rostov-on-DonAlexandra A. Demidova
Rostov State Medical University of the Ministry of Healthcare of Russia
Email: alald@inbox.ru
ORCID iD: 0000-0003-3545-9359
MD, Dr. Sci. (Medicine), head of the Department of medical physics, mathematics and information technologies, Rostov State Medical University of the Ministry of Healthcare of Russia
Russian Federation, Rostov-on-DonSergey V. Shlyk
Rostov State Medical University of the Ministry of Healthcare of Russia
Email: kobzeva.nataliya1@gmail.com
ORCID iD: 0000-0003-3070-8424
MD, Dr. Sci. (Medicine), professor, head of the Department of therapy with a course of outpatient therapy, Rostov State Medical University of the Ministry of Healthcare of Russia
Russian Federation, Rostov-on-DonAnatoly I. Martynov
Russian University of Medicine of the Ministry of Healthcare of Russia
Email: kobzeva.nataliya1@gmail.com
ORCID iD: 0000-0002-0783-488X
MD, Dr. Sci. (Medicine), professor, academician of RAS, professor of the Department of hospital therapy No. 1, Russian University of Medicine of the Ministry of Healthcare of Russia
Russian Federation, MoscowIrina F. Shlyk
Rostov State Medical University of the Ministry of Healthcare of Russia
Email: sushkinaif@mail.ru
ORCID iD: 0000-0003-2193-7372
MD, Dr. Sci. (Medicine), professor of the Department of cardiology, rheumatology and functional diagnostics, Rostov State Medical University of the Ministry of Healthcare of Russia
Russian Federation, Rostov-on-DonReferences
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