Clinical and prognostic value of the skin autofluorescence parameter in coronary heart disease and peripheral arterial disease patients
- Authors: Davydova N.A.1, Lebedev P.A.1, Chernyshev A.V.2, Kornilin D.V.3, Grishanov V.N.3, Komarova M.V.3
-
Affiliations:
- Samara State Medical University of the Ministry of Healthcare of Russia
- V.D. Seredavin Samara Regional Clinical Hospital
- Academician S.P. Korolev Samara National Research University
- Issue: Vol 10, No 2 (2024)
- Pages: 32-40
- Section: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/631821
- DOI: https://doi.org/10.18565/therapy.2024.2.32-40
- ID: 631821
Cite item
Open Access
Access granted
Abstract
Determining the prognosis in patients with a wide range of atherosclerosis clinical manifestations is quite difficult and requires integral parameters, which may include the same as skin autofluorescence (SAF) parameter.
The aim: to establish the prognostic significance of non-invasively determined SAF as a factor of cardiovascular complications and mortality.
Material and methods. Prospective study included 122 male patients hospitalized with peripheral arterial disease (PAD) and 31 male patients with acute coronary syndrome diagnosis. Clinical, anthropometric, biochemical, as well as instrumental parameters of heart and blood vessels were studied using methods of ultrasound investigation. To determine SAF, we used an original device developed by the authors. Control group consisted of 35 practically healthy male patients. The prospective part of the study was performed for up to 1043 days (average 736 days).
Results. SAF values did not differ in the main study groups, but were significantly higher than those in the control group (p < 0.001). SAF positively and significantly correlated with scores on the scale of clinical prognostic signs with chronic arterial insufficiency, the fact of previous operations on the arteries of lower extremities and Syntax coronary stenosis index. During observation period, 7 deaths and at least one hospitalization for cardiovascular reasons in 58 patients took place. Use of logistic and Cox regression methods in the group of PAD patients made it possible to establish that hospitalization or mortality was associated with SAF and plasma glucose, and also with the presence of chronic heart failure above functional class 1. The parameters of the constructed ROC-curve were as following: AUC = 0.73 (sensitivity 71%, specificity 68%). The use of a combined group of patients with coronary heart disease (n = 139) as a test sample was characterized by acceptable model quality: AUC = 0.75.
Conclusion. SAF parameter reflects the processes of remodeling of the cardiovascular system and can be used as an integral independent predictor of complications in patients with different clinical forms of atherosclerosis.
Full Text
About the authors
Nailya A. Davydova
Samara State Medical University of the Ministry of Healthcare of Russia
Author for correspondence.
Email: nelya999@mail.ru
ORCID iD: 0000-0003-1956-3690
MD, postgraduate student of the Department of therapy at the Institute of professional education with a course in functional diagnostics, cardiologist
Russian Federation, 443099, Samara, 89 Chapaevskaya St.Petr A. Lebedev
Samara State Medical University of the Ministry of Healthcare of Russia
Email: palebedev@yahoo.com
ORCID iD: 0000-0003-1404-7099
MD, Dr. Sci. (Medicine), professor, head of the Department of therapy at the Institute of professional education with a course in functional diagnostics
Russian Federation, 443099, Samara, 89 Chapaevskaya St.Alexey V. Chernyshev
V.D. Seredavin Samara Regional Clinical Hospital
Email: avchern70@mail.ru
ORCID iD: 0000-0002-9040-9576
MD, head of the Department of cardiology
Russian Federation, 443095, Samara, 159 Tashkentskaya St.Dmitry V. Kornilin
Academician S.P. Korolev Samara National Research University
Email: kornilin@mail.ru
ORCID iD: 0000-0002-0694-4016
MD, PhD (Tech.), professor of the Department of laser and biotechnical systems
Russian Federation, 443086, Samara, 34 Moskovskoe HighwayVladimir N. Grishanov
Academician S.P. Korolev Samara National Research University
Email: vladgrishanov@yandex.ru
ORCID iD: 0000-0002-6675-4396
MD, PhD (Tech.), associate professor, associate professor of the Department of laser and biotechnical systems
Russian Federation, 443086, Samara, 34 Moskovskoe HighwayMarina V. Komarova
Academician S.P. Korolev Samara National Research University
Email: komarova.mv@ssau.ru
MD, PhD (Biol.), associate professor, associate professor of the Department of laser and biotechnical systems
Russian Federation, 443086, Samara, 34 Moskovskoe HighwayReferences
- Dorresteijn J.A., Visseren F.L., Wassink A.M. et al. Development and validation of a prediction rule for recurrent vascular events based on a cohort study of patients with arterial disease: The SMART risk score. Heart. 2013; 99(12): 866–72. https://doi.org/10.1136/heartjnl-2013-303640. PMID: 23574971.
- Abtan J., Bhatt D.L., Elbez Y. et al.; REACH Registry Investigators. Residual ischemic risk and its determinants in patients with previous myocardial infarction and without prior stroke or TIA: Insights from the REACH registry. Clin Cardiol. 2016; 39(11): 670–77. https://doi.org/10.1002/clc.22583. PMID: 27588731. PMCID: PMC6490735.
- Clemens R.K., Annema W., Baumann F. et. al. Cardiac biomarkers but not measures of vascular atherosclerosis predict mortality in patients with peripheral artery disease. Clin Chim Acta. 2019; 495: 215–20. https://doi.org/10.1016/j.cca.2019.04.061. PMID: 30981846.
- Reddy V.P., Aryal P., Darkwah E.K. Advanced glycation end products in health and disease. Microorganisms. 2022; 10(9): 1848. https://doi.org/10.3390/microorganisms10091848. PMID: 36144449. PMCID: PMC9501837.
- Perrone A., Giovino A., Benny J., Martinelli F. Advanced Glycation End Products (AGEs): Biochemistry, signaling, analytical methods, and epigenetic effects. Oxid Med Cell Longev. 2020; 2020: 3818196. https://doi.org/10.1155/2020/3818196. PMID: 32256950. PMCID: PMC7104326.
- Давыдова Н.А., Лебедев П.А., Аюпов А.М. с соавт. Параметр аутофлюоресценции кожи как фактор неблагоприятного прогноза у пациентов с периферическими формами атеросклероза. Саратовский научно-медицинский журнал. 2022; 18(4): 568–575. [Davydova N.A., Lebedev P.A., Ayupov A.M. et al. Skin autofluorescence parameter as an adverse prognosis factor in patients with peripheral forms of atherosclerosis. Saratovskiy nauchno-meditsinskiy zhurnal = Saratov Journal of Medical Scientific Research. 2022; 18(4): 568–575 (In Russ.)]. EDN: JLCCQS.
- Kornilin D.V., Grishanov V.N., Cherepanov K.V. Pulse excitation fluorescence meter for diagnostic purposes. Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 1068515 (17 May 2018). URL: https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10685/2306588/Pulse-excitation-fluorescence-meter-for-diagnostic-purposes/10.1117/12.2306588.short (date of access – 10.01.2024). https://doi.org/10.1117/12.2306588.
- van Waateringe R.P., Slagter S.N., van Beek A.P. et al. Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is associated with the metabolic syndrome and its individual components. Diabetol Metab Syndr. 2017; 9: 42. https://doi.org/10.1186/s13098-017-0241-1. PMID: 28572855. PMCID: PMC5450154.
- Du T., Brandl B., Hauner H., Skurk T. Skin autofluorescence mirrors surrogate parameters of vascular aging: An enable study. Nutrients. 2023; 15(7): 1597. https://doi.org/10.3390/nu15071597. PMID: 37049440. PMCID: PMC10096848.
- den Dekker M.A., Zwiers M., van den Heuvel E.R. et al. Skin autofluorescence, a non-invasive marker for AGE accumulation, is associated with the degree of atherosclerosis. PLoS One. 2013; 8(12): e83084. https://doi.org/10.1371/journal.pone.0083084. PMID: 24376641. PMCID: PMC3871581.
- Jujic A., Engstrom G., Nilsson P.M., Johansson M. Accumulation of advanced glycation end products in skin and increased vascular ageing in the general population: The Malmo Offspring Study. J Hypertens. 2024; 42(3): 530–37. https://doi.org/10.1097/HJH.0000000000003627. PMID: 38088420. PMCID: PMC10842672.
- Pan J., Bao X., Gonçalves I. et al. Skin autofluorescence, a measure of tissue accumulation of advanced glycation end products, is associated with subclinical atherosclerosis in coronary and carotid arteries. Atherosclerosis. 2022; 345: 26–32. https://doi.org/10.1016/j.atherosclerosis.2022.02.014. PMID: 35196628.
- Chen J., Arshi B., Waqas K. et al. Advanced glycation end products measured by skin autofluorescence and subclinical cardiovascular disease: The Rotterdam Study. Cardiovasc Diabetol. 2023; 22(1): 326. https://doi.org/10.1186/s12933-023-02052-7. PMID: 38017418. PMCID: PMC10685533.
- Cosentino F., Grant P.J., Aboyans V. et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J 2020; 41(2): 255–323.https://doi.org/10.1093/eurheartj/ehz486. PMID: 31497854,
- Heidenreich P.A., Bozkurt B., Aguilar D. et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022; 145(18): e895–e1032.https://doi.org/10.1161/CIR.0000000000001063. PMID: 35379503.
- Cavero-Redondo I., Soriano-Cano A., Alvarez-Bueno C. et al. Skin autofluorescence-indicated advanced glycation end products as predictors of cardiovascular and all-cause mortality in high-risk subjects: A systematic review and meta-analysis. J Am Heart Assoc. 2018; 7(18): e009833. https://doi.org/10.1161/JAHA.118.009833. PMID: 30371199. PMCID: PMC6222966.
Supplementary files
