Association between diabetes mellitus and lower respiratory tract and pulmonary diseases: scientific discussion

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Abstract

Diabetes mellitus (DM) is a not fully studied chronic progressive metabolic disease with multiple complications such as diabetic foot syndrome, retinopathy, and nephropathy. In the context of diabetes, undeservedly little attention is paid to pulmonary lesions, especially if they lead to the development of diabetic lung or have an influence at the pathogenesis of a pulmonary pathology, such as chronic obstructive pulmonary disease or bronchial asthma. Current review summarizes ideas about the role of diabetes in the formation of pulmonary tissue pathology, especially in cases of idiopathic pulmonary fibrosis development in diabetes mellitus patients – a progressive disease with high mortality and limited treatment options.

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About the authors

Sergey L. Babak

Russian University of Medicine of the Ministry of Healthcare of Russia

Author for correspondence.
Email: sergbabak@mail.ru
ORCID iD: 0000-0002-6571-1220
SPIN-code: 5213-3620
Scopus Author ID: 45560913500
ResearcherId: KAO-3183-2024

MD, Dr. Sci. (Medicine), pulmonologist, associate professor, professor of the Department of phthisiology and pulmonology of N.A. Semashko Research and Educational Institute of Clinical Medicine

Russian Federation, 127006, Moscow, 4 Dolgorukovskaya St.

Marina V. Gorbunova

Russian University of Medicine of the Ministry of Healthcare of Russia

Email: mgorb@mail.ru
ORCID iD: 0000-0002-2039-0072
SPIN-code: 6699-1286
Scopus Author ID: 45561369300

MD, Dr. Sci. (Medicine), pulmonologist, associate professor of the Department of phthisiology and pulmonology of N.A. Semashko Research and Educational Institute of Clinical Medicine

Russian Federation, 127006, Moscow, 4 Dolgorukovskaya St.

Ekaterina E. Gubernatorova

Russian University of Medicine of the Ministry of Healthcare of Russia

Email: creativeone@list.ru
ORCID iD: 0009-0009-4149-9497
SPIN-code: 9674-1515

MD, PhD (Medicine), endocrinologist, assistant at the Department of therapy and preventive medicine of N.A. Semashko Research and Educational Institute of Clinical Medicine

Russian Federation, 127006, Moscow, 4 Dolgorukovskaya St.

Andrey G. Malyavin

Russian University of Medicine of the Ministry of Healthcare of Russia

Email: maliavin@mail.ru
ORCID iD: 0000-0002-6128-5914
SPIN-code: 8264-5394
Scopus Author ID: 6701876872

MD, Dr. Sci. (Medicine), pulmonologist, professor of the Department of phthisiology and pulmonology of N.A. Semashko Research and Educational Institute of Clinical Medicine, chief external expert-pulmonologist of the Ministry of Healthcare of Russia in the Central Federal District

Russian Federation, 127006, Moscow, 4 Dolgorukovskaya St.

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Supplementary files

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2. Fig. 1. Components of respiratory dysfunction in patients with diabetes mellitus*

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3. Fig. 2. Schematic representation of respiratory pathology caused by hyperglycemia*

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4. Fig. 3. Schematic representation of the action of insulin on lung tissue*

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5. Fig. 4. Schematic representation of the formation of pulmonary fibrosis in patients with type 2 diabetes mellitus*

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