Comorbid conditions in patients with psoriatic arthritis and hyperuricemia
- Autores: Tsinzerling A.Y.1,2, Mazurov V.I.1,2, Inamova O.V.1,2, Petrova M.S.1,2, Gaydukova I.Z.1,2
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Afiliações:
- I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia
- V.A. Nasonova Clinical Rheumatology Hospital No. 25
- Edição: Volume 11, Nº 1 (2025)
- Páginas: 74-80
- Seção: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/679684
- DOI: https://doi.org/10.18565/therapy.2025.1.74-80
- ID: 679684
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Resumo
Both hyperuricemia (HU) and psoriatic arthritis (PsA) have an adverse influence at cardiovascular, metabolic diseases, and chronic kidney disease (CKD).
The aim: to study the incidence of comorbid diseases, their clinical course, characteristics, and efficacy of urate-lowering therapy (ULT) in case of PsA and HU combination.
Material and methods. Retrospective data of patients with PsA and HU (n = 130) and PsA without HU (n = 131) were studied. HU was considered as an increase in serum uric acid (UA) ≥ 360 μmol/L in the absence of gouty arthritis.
Results. PsA patients with and without HU were comparable in age, gender, disease activity, and immunogenetic characteristics. In the group of patients with PsA and HU, comparatively to PsA without HU, arterial hypertension (68.46 and 40.46%, respectively), hypercholesterolemia (53.08 and 27.48%), obesity (25.38 and 6.87%), prediabetes (21.54 and 12.21%), type 2 diabetes mellitus (DM 2) (29.23 and 12.21%), CKD (51.54 and 29.77%) were more common, in addition, the first group had a higher creatinine level (87.79 ± 19.26 and 77.86 ± 11.42 μmol/l); p < 0.05 for all parameters. Non-medicamentous ULT was effective in 30.36% of patients, medicamentous ULT – in 23.07%. These data can be explained by the fact that examined patients did not comply with the ULT dosing regimen and they stopped such therapy on their own. The efficacy of ULT did not depend on PsA activity: 81.25% of patients with moderate and 55.26% with high disease activity did not achieve the target UA level (p = 0.01).
Conclusion. HU leads to an increase in the incidence of hypertension, dyslipidemia, obesity, prediabetes, DM 2, and CKD in patients having PsA. The efficacy of non-medicamentous and medicamentous-based ULT in such patients is comparable in terms of target UA indicators achieving. It is advisable to continue studying the correlation between PsA activity and the efficacy of ULT.
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Sobre autores
Alexandra Tsinzerling
I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia; V.A. Nasonova Clinical Rheumatology Hospital No. 25
Autor responsável pela correspondência
Email: aleksa.fonturenko@mail.ru
ORCID ID: 0000-0003-4860-0518
Código SPIN: 5613-9035
MD, PhD (Medicine), rheumatologist, senior laboratory assistant at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald
Rússia, 191015, Saint Petersburg, 41 Kirochnaya St.; 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya St.Vadim Mazurov
I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia; V.A. Nasonova Clinical Rheumatology Hospital No. 25
Email: maz.nwgmu@yandex.ru
ORCID ID: 0000-0002-0797-2051
Código SPIN: 6823-5482
Scopus Author ID: 16936315400
MD, Dr. Sci. (Medicine), professor, academician of RAS, vice president of RSMSIM, principal scientific advisor and director of the Research Institute of Rheumatology, head of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald, head of Autoimmune center, chief freelance specialist – rheumatologist of the Healthcare Committee of the Government of Saint Petersburg, Honored Worker of Science of the Russian Federation
Rússia, 191015, Saint Petersburg, 41 Kirochnaya St.; 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya St.Oksana Inamova
I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia; V.A. Nasonova Clinical Rheumatology Hospital No. 25
Email: ovig74@mail.ru
ORCID ID: 0000-0001-9126-3639
Código SPIN: 8841-5496
MD, PhD (Medicine), deputy director of the Research Institute of Rheumatology, assistant at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald, chief physician
Rússia, 191015, Saint Petersburg, 41 Kirochnaya St.; 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya St.Marianna Petrova
I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia; V.A. Nasonova Clinical Rheumatology Hospital No. 25
Email: podagra@bk.ru
ORCID ID: 0000-0001-5261-6614
MD, PhD (Medicine), associate professor of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald, deputy chief physician
Rússia, 191015, Saint Petersburg, 41 Kirochnaya St.; 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya St.Inna Gaydukova
I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia; V.A. Nasonova Clinical Rheumatology Hospital No. 25
Email: ubp1976@list.ru
ORCID ID: 0000-0003-3500-7256
Código SPIN: 3083-7996
MD, Dr. Sci. (Medicine), deputy director of the Research Institute of Rheumatology, professor of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald, rheumatologist
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