Electrocardiograms of patients who survived after COVID-19

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Infection caused by SARS-CoV-2, seriously affects the cardiovascular system, which is manifested by changes in electrocardiogram (ECG).

The aim: to study the ECG of patients survived from COVID-19.

Material and methods. 352 patients with COVID-19 underwent ECG upon admission, during treatment in hospital and before discharge. Heart rate (HR), cardiac electrical axis position, cardiac rhythm, extrasystoles, bundle branch block, ST segment and T wave (ST) abnormalities, ischemic events, and presence of acute myocardial infarction were estimated.

Results. Patients with COVID-19 were mostly admitted to the hospital with a normal heart rate. Sinus tachycardia was more often detected in females upon discharge and in male patients upon admission; sinus bradycardia was more often detected upon discharge than upon admission. This tendency was typical for both female and male individuals. Supraventricular and ventricular extrasystoles were rare. Atrial fibrillation and atrial flutter were twice as common in male, and first-degree atrioventricular blocks were found in female patients. No patients had incomplete left bundle branch block (LBBBi). Complete left bundle branch block (LBBBc) upon admission and discharge was registered in 3 male individuals. LBBBc, LBBBi and left anterior superior fascicle block were observed equally often both at admission and at discharge. Ischemic myocardial abnormalities were rare. cST and T anomalies were equally often verified both at admission and at discharge, they were almost 3 times more in females. Acute myocardial infarction was not diagnosed in any patient either at admission or at discharge.

Conclusion. Changes in ECG pattern of patients survived from COVID-19 are slightly different from those in individuals without this pathology.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Rafik Saifutdinov

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia; City Clinical Hospital No. 12

Хат алмасуға жауапты Автор.
Email: rgsbancorp@mail.ru
ORCID iD: 0000-0003-2839-100X
SPIN-код: 2339-9660

MD, Dr. Sci. (Medicine), professor, head of the Department of hospital and outpatient therapy

Ресей, Kazan; Kazan

Rinat Saifutdinov

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia; City Clinical Hospital No. 12

Email: r_saifutdinov@mail.ru
SPIN-код: 5725-0092

MD, PhD (Medicine), associate professor, associate professor of the Department of hospital and outpatient therapy, head of the Department of therapy

Ресей, Kazan; Kazan

Alsu Galyautdinova

City Clinical Hospital No. 12

Email: gaa270565@yandex.ru

MD, doctor of the Functional Department

Ресей, Kazan

Laysan Muginova

City Clinical Hospital No. 12

Email: Muginovalkk@gmail.com

MD, doctor of the Functional Department

Ресей, Kazan

Nailya Mukhametzyanova

City Clinical Hospital No. 18

Email: Gb18ofdzav@mail.ru

MD, PhD (Medicine), head of the Functional Department

Ресей, Kazan

Akmal Akramzhanov

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: akromjanov3@gmail.com

clinical resident of the Department of hospital and outpatient therapy

Ресей, Kazan

Zilya Akhmetzyanova

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: zilunchik9@gmail.com

clinical resident of the Department of hospital and outpatient therapy

Ресей, Kazan

Gulnara Galiullina

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: english-worker@mail.ru

clinical resident of the Department of hospital and outpatient therapy

Ресей, Kazan

Rania Gilmullina

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: kalinino10@gmail.com

clinical resident of the Department of hospital and outpatient therapy

Ресей, Kazan

Varvara Dzyuina

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: pestereva.varvara@mail.ru

clinical resident of the Department of hospital and outpatient therapy

Ресей, Kazan

Timur Murakaev

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: murakaevafarida@yandex.ru

clinical resident of the Department of hospital and outpatient therapy

Ресей, Kazan

Aigul Mukhametzyanova

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: lolkeks98@mail.ru

clinical resident of the Department of hospital and outpatient therapy

Ресей, Kazan

Elina Sultanova

Kazan State Medical Academy – a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: Elli-su.sultanova@yandex.ru

clinical resident of the Department of hospital and outpatient therapy

Ресей, Kazan

Әдебиет тізімі

  1. Sciaccaluga C, Cameli M, Menci D, Mandoli GE, Sisti N, Cameli P et al. COVID-19 and the burning issue of drug interaction: Never forget the ECG. Postgrad Med J. 2021;97(1145):180–84. PMID: 32820084. PMCID: PMC10016843. https://doi.org/10.1136/postgradmedj-2020-138093
  2. Yu L, Liu Y, Feng Y. Cardiac arrhythmia in COVID-19 patients. Ann Noninvasive Electrocardiol. 2024;29(2):e13105. PMID: 38339786. PMCID: PMC10858328. https://doi.org/10.1111/anec.13105
  3. Thakur A, Kapil A, Deepti S. An abnormal ECG finding in a patient with COVID-19. JAMA Intern Med. 2023;183(11):1261–62. PMID: 37695593. https://doi.org/10.1001/jamainternmed.2023.2457
  4. Gomes JC, de Santana MA, Masood AI, de Lima CL, Dos Santos WP. СOVID-19’s influence on cardiac function: A machine learning perspective on ECG analysis. Med Biol Eng Comput. 2023;61(5):1057–81. PMID: 36662377. PMCID: PMC9854415. https://doi.org/10.1007/s11517-023-02773-7
  5. Hashimoto H, Hiyoshi Y, Kabuki T, Sasaki H, Toda M. Prognostic value of ECG monitor findings in COVID-19. Open Heart. 2023;10(2):e002404. PMID: 37963684. PMCID: PMC10649884. https://doi.org/10.1136/openhrt-2023-002404
  6. Временные методические рекомендации Минздрава России «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)». Версия 6 (28.04.2020). Доступ: https://minzdrav.gov.ru/system/attachments/attaches/000/050/122/original/28042020_%D0%9CR_COVID-19_v6.pdf (дата обращения – 21.03.2025). [Interim methodological recommendations of the Ministry of Healthcare of Russia “Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)”. Version 6 (28.04.2020). URL: https://minzdrav.gov.ru/system/attachments/attaches/000/050/122/original/28042020_%D0%9CR_COVID-19_v6.pdf (date of access – 21.03.2025) (In Russ.)].
  7. Сайфутдинов Р.Г., Сайфутдинов Р.Р., Сайфутдинова Т.В., Галяутдинова А.А., Мугинова Л.К., Галиуллина Г.Ф. с соавт. Анализ в динамике электрокардиограмм пациентов, умерших от COVID-19, при поступлении, в процессе лечения в стационаре и перед смертью. Терапия. 2024;10(3):26–40. [Saifutdinov RG, Saifutdinov RR, Saifutdinova TV, Galyautdinova AA, Muginova LK, Galiullina GF et al. Analysis of the dynamics of electrocardiograms of patients who died from COVID-19 on admission, during treatment in a hospital and before death. Terapiya = Therapy. 2024;10(3):26–40 (In Russ.)]. EDN: TMPIHI. https://doi.org/10.18565/therapy.2024.3.26-40
  8. Chevrot G, Hauguel-Moreau M, Pépin M, Vieillard-Baron A, Lot A-S, Ouadahi M et al. Electrocardiogram abnormalities and prognosis in COVID-19. Front Cardiovasc Med. 2022;9:993479. PMID: 36277756. PMCID: PMC9581294. https://doi.org/10.3389/fcvm.2022.993479
  9. Souris M, Gonzalez J-P. COVID-19: Spatial analysis of hospital case fatality rate in France. PLoS ONE. 2020;15(12):e0243606. PMID: 33320895. PMCID: PMC7737987. https://doi.org/10.1371/journal.pone.0243606
  10. Antwi-Amoabeng D, Beutler BD, Singh S, Taha M, Ghuman J, Hanfy A et al. Association between electrocardiographic features and mortality in COVID-19 patients. Ann Noninvasive Electrocardiol. 2021;26(4):e12833. PMID: 33742501. PMCID: PMC8250310. https://doi.org/10.1111/anec.12833
  11. Jabbari L, Hayati S, Azizkhani L, Tavakol J. Association of electrocardiographic abnormalities and COVID-19 clinical outcomes. J Electrocardiol. 2023;78:76–79. PMID: 36863119. PMCID: PMC9951026. https://doi.org/10.1016/j.jelectrocard.2023.02.002
  12. Lanza GA, De Vita A, Ravenna SE, D’Aiello A, Covino M, Franceschi F, Crea F. Electrocardiographic findings at presentation and clinical outcome in patients with SARS-CoV-2 infection. Europace. 2021;23(1):123–29. PMID: 33097933. PMCID: PMC7665485. https://doi.org/10.1093/europace/euaa245
  13. De Carvalho H, Leonard-Pons L, Segard J, Goffinet N, Javaudin F, Martinage A et al. Electrocardiographic abnormalities in COVID-19 patients visiting the emergency department: A multicenter retrospective study. BMC Emergency Medicine. BMC Emerg Med. 2021;21(1):141. PMID: 34798827. PMCID: PMC8603337. https://doi.org/10.1186/s12873-021-00539-8
  14. Gur A, Ulutas Z. Characteristic electrocardiography findings of COVID-19 patients. Arch Iran Med. 2021;24(9):706–12. PMID: 34816689. https://doi.org/10.34172/aim.2021.103
  15. Tereshchenko LG, Pourbemany J, Haq KT, Patel H, Hyde J, Quadri S et al. An electrophysiological substrate of COVID-19. J Electrocardiol. 2023;79:61–65. PMID: 36963283. PMCID: PMC10027233. https://doi.org/10.1016/j.jelectrocard.2023.03.010
  16. Орлов В.Н. Руководство по электрокардиографии. 5-е изд., испр. М.: Медицинское информационное агентство. 2006; 528 с. [Orlov VN. Manual of electrocardiography. 5th edition, revised. Moscow: Medical Information Agency. 2006; 528 pp. (In Russ.)].
  17. Romero J, Gabr M, Diaz JC, Purkayastha S, Gamero MT, Reynbakh O. et al. Electrocardiographic features of patients with COVID-19: An updated review. Card Electrophysiol Clin. 2022;14(1):63–70. PMID: 35221086. PMCID: PMC8556537. https://doi.org/10.1016/j.ccep.2021.10.006
  18. Abrams MP, Wan EY, Waase MP, Morrow JP, Dizon JM, Yarmohammadi H et al. Clinical and cardiac characteristics of COVID-19 mortalities in a diverse New York City Cohort. J Cardiovasc Electrophysiol. 2020;31(12):3086–96. PMID: 33022765. PMCID: PMC7675758. https://doi.org/10.1111/jce.14772
  19. Beyls C, Martin N, Hermida A , Abou-Arab O, Mahjoub Y. Lopinavir – ritonavir treatment for COVID-19 infection in intensive care unit. Risk of bradycardia. Circ Arrhythm Electrophysiol. 2020;13(8):e008798. PMID: 32809882. PMCID: PMC7446985. https://doi.org/10.1161/circep.120.008798
  20. Brunetti ND, Poliseno M, Bottalico IF, Centola A, Montemurro L, Sica S et al. Safety and heart rate changes in Covid-19 patients treated with remdesivir. Int J Infect Dis. 2021;112:254–57. PMID: 34551344. PMCID: PMC8451471. https://doi.org/10.1016/j.ijid.2021.09.036
  21. Barman HA, Atici A, Alici G, Sit O, Tugrul S, Gungor B et al. The effect of the severity COVID-19 infection on electrocardiography. Am J Emerg Med. 2021;46:317–22. PMID: 33059987. PMCID: PMC7539927. https://doi.org/10.1016/j.ajem.2020.10.005
  22. Ozdemir IH, Ozlek B, Ozen MB. Fragmented QRS is a marker of mortality in patients with severe COVID-19: A retrospective observational study. Anatol J Cardiol. 2021;25(11):811–20. PMID: 34734815. PMCID: PMC8575396. https://doi.org/10.5152/AnatolJCardiol.2021.62
  23. Сайфутдинов Р.Г., Ахметов Р.У., Сайфутдинов Р.Р., Трефилова Ю.С., Сайфутдинова Т.В. К вопросу о гипергликемии при COVID-19. Дневник Казанской медицинской школы. 2022;(3):4–10. [Saifutdinov RG, Akhmetov RU, Saifutdinov RR, Trefilova YuS, Saifutdinova TV. On the issue of hyperglycemia in COVID-19. Dnevnik Kazanskoj meditsinskoj shkoly = Kazan medical school diary. 2022;(3):4–10 (In Russ.)]. EDN: GNLZYV.
  24. Khunti K, Del Prato S, Mathieu C, Kahn SE, Gabbay RA, Buse JB et al. COVID-19, hyperglycemia, and new-onset diabetes. Diabetes Care. 2021;44(12):2645–55. PMID: 34625431. PMCID: PMC8669536. https://doi.org/10.2337/dc21-1318
  25. Michalakis K, Ilias I. COVID-19 and hyperglycemia/diabetes. World J Diabetes. 2021;12(5):642–50. PMID: 33995851. PMCID: PMC8107977. https://doi.org/10.4239/wjd.v12.i5.642
  26. Saifutdinov RG, Saifutdinov RR, Achmedov RU, Trefilova US, Saifutdinova TV. Hyperglycemia in COVID-19. Review. EC Clinical and Medical Case Reports. 2023;6(4):9–18.
  27. Roy S, Demmer RT. Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes. Transl Res. 2022;241:52–69. PMID: 34763125. PMCID: PMC8575538. https://doi.org/10.1016/j.trsl.2021.11.002
  28. Килинский Е.Л., Высокий Ф.Ф. Генез электрокардиографических изменений при сахарной пробе. Вестник Академии медицинских наук. 1965;20(10):72–77. [Kilinsky EL, Vysoky FF. The genesis of electrocardiographic changes in a sugar sample. Vestnik Akademii meditsinskikh nauk = Bulletin of the Academy of Medical Sciences. 1965;20(10):72–77 (In Russ.)].
  29. Giustino G, Croft LB, Stefanini GG, Bragato R, Silbiger JJ, Vicenzi M et al. Characterization of myocardial injury in patients with COVID-19. J Am Coll Cardiol. 2020;76(18):2043–55. PMID: 33121710. PMCID: PMC7588179. https://doi.org/10.1016/j.jacc.2020.08.069

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Bionika Media, 2025