Generalized destructive tuberculosis process with drug resistance of a causative agent in a vegetarian family

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Tuberculosis patients who suffer from malnutrition have more severe forms of the disease, high risks of death and poor treatment outcomes. In this regard, we present a clinical observation of a 38-year-old female patient and a 42-year-old male patient (husband and wife) hospitalized at the Central research institute of tuberculosis in February 2024 in a severe clinical condition. Upon admission, the patients had severe inflammatory syndrome and generalized tuberculous process in lung tissue with massive bacterial excretion. Moreover, there was a pronounced protein-energy deficiency, which led to the rapid progression of a specific process. A comprehensive approach is needed to treat that certain category of patients, which should not be limited to the use of anti-tuberculosis chemotherapy drugs.

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作者简介

Nikita Chumovatov

Central Research Institute of Tuberculosis

编辑信件的主要联系方式.
Email: Necro5412@mail.ru
ORCID iD: 0000-0001-8745-7940
SPIN 代码: 7088-5717

MD, PhD (Medicine), researcher at the Department of phthisiology

俄罗斯联邦, Moscow

Natalya Chernykh

Central Research Institute of Tuberculosis

Email: natadok@inbox.ru
ORCID iD: 0000-0001-6787-2362
SPIN 代码: 9144-7729

MD, PhD (Medicine), senior researcher at the Department of phthisiology

俄罗斯联邦, Moscow

Oksana Komissarova

Central Research Institute of Tuberculosis; N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia (Pirogov University)

Email: oksana.komissarova.72@mail.ru
ORCID iD: 0000-0003-4427-3804

MD, Dr. Sci. (Medicine), associate professor, deputy director for scientific and medical work of the Department of phthisiology, professor of the Department of phthisiology

俄罗斯联邦, Moscow; Moscow

参考

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2. Fig. 1. Axial sections of computed tomography of the chest organs of the observed patient O. in the pulmonary regime: A - massive cavity of decay in the right lung; B - focal infiltrative changes in both lungs

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3. Fig. 2. Axial sections of computed tomography of the chest organs of the observed patient E. in the pulmonary regime: A, B - massive cavities of decay in both lungs and focal infiltrative changes in lung tissue

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4. Fig. 3. Axial sections of computed tomography of the chest organs of the observed patient O. in the pulmonary regime: A - reduction of the decay cavity in the right lung; B - resorption of focal infiltrative changes in both lungs

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5. Fig. 4. Axial sections of computed tomography of the chest organs of the observed patient E. in the pulmonary regime: A - reduction of decay cavities in both lungs; B - resorption of focal infiltrative changes in both lungs

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