Lupus nephritis in combination with a novel coronavirus infection (COVID-19) in a 42-year-old male patient

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Kidney damage in systemic lupus erythematosus (SLE) – lupus nephritis (LN) – often becomes the only manifestation of the disease. Signs of LN are varied: from mild proteinuria to rapidly progressing glomerulonephritis with impaired nitrogen-excreting function of the kidneys, which largely depends on the morphological picture. Special histological changes in the kidneys in case of LN include mesangial hypercellularity, expansion of mesangium, proliferation of endothelium, changes in the basement membranes of capillaries. Sometimes areas of necrosis of the capillary loops and crescents are detected. Most patients with SLE are females, and accordingly, they are more often diagnosed with diseased kidneys. In male individuals, LN is mostly combined with damage of other organs. Presented clinical observation demonstrates the insufficient alertness of doctors regarding SLE in male patients.

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作者简介

Olga Kvasova

Penza State University of the Ministry of Science and Higher Education of the Russian Federation

编辑信件的主要联系方式.
Email: olhakvasova@yandex.ru
ORCID iD: 0009-0005-8531-618X
SPIN 代码: 6911-1640

MD, PhD (Medicine), associate professor of the Department of therapy, faculty of general medicine

俄罗斯联邦, Penza

Ekaterina Klimova

N.N. Burdenko Penza Regional Clinical Hospital

Email: klim-e85@yandex.ru
ORCID iD: 0009-0006-5818-3550
SPIN 代码: 4488-9039

MD, nephrologist at the Department of nephrology

俄罗斯联邦, Penza

Irina Trushina

Regional Office of the Chief Medical Examiner

Email: trushinairen@yandex.ru
ORCID iD: 0009-0002-7829-6203

MD, pathologist

俄罗斯联邦, Penza

Svetlana Fadeeva

N.N. Burdenko Penza Regional Clinical Hospital

Email: sfadeeva028@gmail.com
ORCID iD: 0000-0002-0812-5735
SPIN 代码: 2710-4994

MD, PhD (Medicine), associate professor, head of the Department of rheumatology

俄罗斯联邦, Penza

Irina Alimova

N.N. Burdenko Penza Regional Clinical Hospital

Email: irinalimova@mail.ru
ORCID iD: 0009-0008-0612-414X

MD, head of the Department of nephrology

俄罗斯联邦, Penza

参考

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2. Fig. 1. Macro-preparation of the kidney of the observed patient (photo by the authors)

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3. Fig. 2. Macro-preparation of the kidney of the observed patient in the section (photo by the authors): A - the kidney tissue is mottled, there is no differentiation between the cerebral and cortical layers; B - the cup-pelvic system is not deformed, its mucosa is gray with small drainage hemorrhages

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4. Fig. 3. Micro—preparation of the kidneys of the observed patient (Romanovsky-Giemse staining): A - magnification x 100; B - magnification x 200 (photo by the authors)

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