«Colossus with feet of clay»: a case report

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The incidence of drug-induced diseases increases every year. The number of cases of off-label drug use is growing too. Current article presents a clinical observation of a bodybuilder with hereditary thrombophilia. It describes in detail the effects of testosterone medications on various organs and systems (cardiovascular, hematopoiesis, kidneys, prostate, hemostasis), analyzing side effects using a specific example. Mechanisms of renal damage associated with a high-protein diet are discussed. This clinical case illustrates the challenges of managing patients with drug-induced diseases, emphasizing the importance of awareness by physicians about systemic effects of testosterone-containing medications and high-protein diet.

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作者简介

Tatyana Adasheva

Russian University of Medicine of the Ministry of Healthcare of Russia

编辑信件的主要联系方式.
Email: adashtv@mail.ru
ORCID iD: 0000-0002-3763-8994

MD, Dr. Sci (Medicine), professor, professor of the Department of therapy and preventive medicine

俄罗斯联邦, Moscow

Ekaterina Gubernatorova

Russian University of Medicine of the Ministry of Healthcare of Russia

Email: creativeone@list.ru
ORCID iD: 0009-0009-4149-9497

MD, PhD (Medicine), assistant at the Department of therapy and preventive medicine

俄罗斯联邦, Moscow

Valeria Boltikova

Russian University of Medicine of the Ministry of Healthcare of Russia

Email: vboltikova00@mail.ru
ORCID iD: 0009-0007-0237-884X

MD, resident of the Department of therapy and preventive medicine

俄罗斯联邦, Moscow

Leili Akhmedyarova

Reaviz Medical University; Hospital of Centrosoyuz of the Russian Federation

Email: ahleyli@gmail.com
ORCID iD: 0000-0002-7640-6352

MD, PhD (Medicine), associate professor of the Department of internal medicine, head of the Department of therapy

俄罗斯联邦, Moscow; Moscow

Kamila Bagatyrova

Russian University of Medicine of the Ministry of Healthcare of Russia

Email: akamila1981@yandex.ru
ORCID iD: 0000-0002-2529-3167

MD, PhD (Medicine), associate professor of the Department of therapy and preventive medicine

俄罗斯联邦, Moscow

参考

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2. Fig. 1. Electrocardiogram of the observed patient

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3. 2. Perfusion scintigraphy + single-photon emission computed tomography with traditional computed tomography of the lungs in the observed patient

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4. Fig. 3. Holter electrocardiogram monitoring in the observed patient

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5. Fig. 4. The effect of testosterone preparations on the human body

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6. 5. Various risk factors and mechanisms of renal dysfunction in athletes and bodybuilders*

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7. 6. Mechanisms of renal damage associated with high protein content in the diet*

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